Phenylpropanoids from the leaves of Acanthopanax koreanum and their antioxidant activity.

Abstract:

:By various chromatographic methods, one new phenylpropanoid, acanthopanic acid (1), and three known compounds, 1,2-O-dicaffeoylcyclopenta-3-ol (2), (4S)-α-terpineol 8-O-β-D-glucopyranoside (3), and rutin (4), were isolated from the methanol extract of the Acanthopanax koreanum leaves. Their structures were elucidated on the basis of spectroscopic analyses, and their antioxidant activities were evaluated by the intracellular reactive oxygen species (ROS) radical scavenging 2',7'-dichlorofluorescein diacetate assay. Among them, compounds 1, 2, and 4 showed significant scavenging capacity with IC(50) values of 3.8, 2.6, and 2.9 μM, respectively, and compound 3 showed weak scavenging capacity with the inhibition rate of 37% at 40 μM.

journal_name

J Asian Nat Prod Res

authors

Nhiem NX,Kim KC,Kim AD,Hyun JW,Kang HK,Van Kiem P,Van Minh C,Thu VK,Tai BH,Kim JA,Kim YH

doi

10.1080/10286020.2010.525743

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

56-61

issue

1

eissn

1028-6020

issn

1477-2213

pii

932556926

journal_volume

13

pub_type

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