Abstract:
:A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamine and 10 novel-substituted 3-benzylmercapto-1,2,4-triazol derivatives were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS, and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazol derivatives displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds 8b, 8h, and 8i showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds 8b, 8c, and 8h displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrate that compounds 8b, 8c, and 8h are promising fungicidal candidates, deserving further studies.[Formula: see text].
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Li XJ,Zhang W,Zhao CN,Wu QL,Li JK,Xu ZHdoi
10.1080/10286020.2020.1754400subject
Has Abstractpub_date
2020-05-07 00:00:00pages
1-14eissn
1028-6020issn
1477-2213pub_type
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