Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives.

Abstract:

:A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamine and 10 novel-substituted 3-benzylmercapto-1,2,4-triazol derivatives were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS, and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazol derivatives displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds 8b, 8h, and 8i showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds 8b, 8c, and 8h displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrate that compounds 8b, 8c, and 8h are promising fungicidal candidates, deserving further studies.[Formula: see text].

journal_name

J Asian Nat Prod Res

authors

Li XJ,Zhang W,Zhao CN,Wu QL,Li JK,Xu ZH

doi

10.1080/10286020.2020.1754400

subject

Has Abstract

pub_date

2020-05-07 00:00:00

pages

1-14

eissn

1028-6020

issn

1477-2213

pub_type

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