An in vitro study of the structure-activity relationships of sulfated polysaccharide from brown algae to its antioxidant effect.

Abstract:

:In this paper, the structure-activity relationships of chemically modified uronic acid polymer fragments from brown algae with regard to their antioxidant effects on H2O2-damaged lymphocyte were studied. The results indicated that the most potent antioxidant activity was obtained from the sulfated polysaccharide with ratio of mannuronate blocks (M-blocks) to guluronate blocks (G-blocks) of 3 to 1 and carboxyl residue unesterified. The sulfated G-blocks with esterified carboxyl residue also prevented lymphocyte from injury. However, the sulfated G-blocks bearing unesterified carboxyl residue hardly exerted antioxidant activity. These findings suggested that both M-blocks and esterified carboxyl residue were determinant structures in preventing lymphocyte from being oxidized by H202, indicating that the existence of M-blocks was more important in scavenging free radicals.

journal_name

J Asian Nat Prod Res

authors

Hu JF,Gen MY,Zhang JT,Jiang HD

doi

10.1080/10286020108040376

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

353-8

issue

4

eissn

1028-6020

issn

1477-2213

journal_volume

3

pub_type

杂志文章
  • Two new furostanol glycosides from the fibrous root of Ophiopogon japonicus (Thunb.) Ker-Gawl.

    abstract::Two new furostanol glycosides, ophiopogonins H (1) and I (2), were isolated from the fibrous root of Ophiopogon japonicus. The structures of 1 and 2 were established as (25R)-26-[(O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl)]-22α-hydroxyfurost-5-ene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and (25R)-26-[(...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2010.495332

    authors: Duan CL,Ma XF,Jiang Y,Liu JX,Tu PF

    更新日期:2010-09-01 00:00:00

  • Influence of sulfation on anti-myocardial ischemic activity of Ophiopogon japonicus polysaccharide.

    abstract::Ophiopogon japonicus polysaccharide (FOJ-5) from Radix ophiopogonis has shown anti-myocardial ischemic action in vitro and in vivo in our previous studies. In order to clarify the influence of chemical modifications on the action, a series of sulfated FOJ-5 (FOJ-5-S) with different substitution degrees were prepared a...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020902727363

    authors: Zheng Q,Feng Y,Xu DS,Lin X,Chen YZ

    更新日期:2009-01-01 00:00:00

  • (+)-Cyclopenol, a new naturally occurring 7-membered 2,5-dioxopiperazine alkaloid from the fungus Penicillium sclerotiorum endogenous with the Chinese mangrove Bruguiera gymnorrhiza.

    abstract::One new naturally occurring 7-membered 2,5-dioxopiperazine alkaloid named (+)-cyclopenol (1), along with nine known compounds including viridicatol (2), 3-(dimethylaminomethyl)-1-(1,1-dimethyl-2-propenyl)indole (3), anacine (4), aurantiomide C (5), viridicatin (6), 3-O-methylviridicatin (7), verrucosidin (8), ergoster...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2014.911290

    authors: Li J,Wang J,Jiang CS,Li G,Guo YW

    更新日期:2014-01-01 00:00:00

  • Two new neolignan glucosides from Arctii Fructus.

    abstract::Two new neolignan glucosides named (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxyl-7'-oxo-8-4'-oxyneolignan-4-O-β-D-glucopyranoside and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-D-glucopyranosyl-4'-O-β-D-glucopyranoside, together with two small molecular peptides named 3-benzyl-6-(1-...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2012.729050

    authors: Yang YN,Zhang F,Feng ZM,Jiang JS,Zhang PC

    更新日期:2012-01-01 00:00:00

  • A pair of 24-hydroperoxyl epimeric dammarane saponins from flower-buds of Panax ginseng.

    abstract::Further investigation on the saponins of the flower-buds of Panax ginseng C. A. Meyer has resulted in the isolation and structural elucidation of a pair of new 24-epimers of dammarane type saponins named ginsenoside I and II. The structures of the epimers were characterized on the basis of chemical and spectral eviden...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020108041396

    authors: Qiu F,Ma ZZ,Xu SX,Yao XS,Che CT,Chen YJ

    更新日期:2001-01-01 00:00:00

  • Irritant and cytotoxic coumarins from Angelica glauca Edgew roots.

    abstract::Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and nodakenetin, were investigated. The irritant potential was explored by open mou...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020701273759

    authors: Saeed MA,Sabir AW

    更新日期:2008-01-01 00:00:00

  • Two new phthalate derivatives from Nepeta clarkei (Labiatae).

    abstract::Two new phthalates bis(2-ethylundecyl)phthalate and bis(2-ethyltridecyl)phthalate have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei along with one known compound β-amyrin. The structures of the two new compounds and β-amyrin were assigned on the basis of their ¹H and ¹³C NMR s...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2011.620954

    authors: Hussain J,Rehman NU,Hussain H,Ali L,Al-Harrasi A

    更新日期:2012-01-01 00:00:00

  • New cycloartanes and new iridoids from Dolichandrone spathacea collected in the mangrove forest of Soc Trang province, Vietnam.

    abstract::Two new cycloartanes, named dolichandrone A (1) and dolichandrone B (2), as well as two new iridoids, named [6-O-[(E)-4-methoxycinnamoyl]-1β-hydroxy-dihydrocatalpolgenin (3) and 6-O-[(E)-4-methoxycinnamoyl]-1α-hydroxy-dihydrocatalpolgenin (4), together with four known iridoids (5-8), were isolated from the leaves and ...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2017.1406927

    authors: Nguyen VT,Do LQ,Nguyen TA,Nguyen TT,Tran VL,Ho NA,Tran VC,Tran VS,Tran TPT

    更新日期:2018-09-01 00:00:00

  • Two new selaginellin derivatives from Selaginella tamariscina (Beauv.) Spring.

    abstract::Two new selaginellin derivatives, selaginellins K (1) and L (2), were isolated from Selaginella tamariscina (Beauv.) Spring and characterized as 2-formyl-4,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene and 4,4'-dihydroxy-2-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene on the basis of their spectroscopic data including...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2011.558840

    authors: Xu KP,Zou H,Li FS,Xiang HL,Zou ZX,Long HP,Li J,Luo YJ,Li YJ,Tan GS

    更新日期:2011-04-01 00:00:00

  • Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum.

    abstract::A new pyranoxanthone, venuloxanthone (1), was isolated from the stem bark of Calophyllum venulosum, together with three other xanthones, tovopyrifolin C (2), ananixanthone (3) and caloxanthone I (4), along with two common triterpenes, friedelin (5) and lupeol (6). The structures of these compounds were identified usin...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2015.1047353

    authors: Bin Ismail AA,Ee GC,Bin Daud S,Teh SS,Hashim NM,Awang K

    更新日期:2015-01-01 00:00:00

  • One-pot synthesis of a 3,6-branched hexaarabinogalactan using galactopyranosyl thioglycoside diol as a key glycosylating agent.

    abstract::We present in this paper the efficient four-component one-pot synthesis of a fully protected hexaarabinogalactan 2 with di-branched structure by using D-thiogalactopyranoside 3,6-diol 3 as the central glycosylating agent. After global deprotection, 2 was converted into the 3-aminopropyl linker-containing free oligosac...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2014.917084

    authors: Huang H,Han L,Lan YM,Zhang LL

    更新日期:2014-01-01 00:00:00

  • Alashanoids K-M, bioactive eremophilane sesquiterpenoids from Syringa pinnatifolia.

    abstract::Three new eremophilane-type sesquiterpenoids, alashanoids K-M (1-3), and one known analogue (4) were isolated from the peeled stems of Syringa pinnatifolia. All the compounds were isolated from the genus Syringa for the first time. Structures of these compounds were established using 1D and 2D NMR and MS data. The abs...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2019.1694516

    authors: Peng B,Zhang RF,Du BZ,Jiao SG,Zhou XC,Gao XL,Chen SY,Tu PF,Chai XY

    更新日期:2019-12-01 00:00:00

  • Terpenoids and their anti-feedant activity from Cipadessa cinerascens.

    abstract::Eight tetranortriterpenoids (1-8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1β-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR an...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2014.938060

    authors: Fu LR,Ma QY,Huang SZ,Dai HF,Guo ZK,Yu ZF,Zhao YX

    更新日期:2014-01-01 00:00:00

  • Alkaloids with antioxidant activities from Aconitum handelianum.

    abstract::A new C20-diterpenoid alkaloid handelidine (1) and twenty-seven known alkaloids (2-28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C20-diterpenoid alkaloids with vicinal-triol system a...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2015.1114473

    authors: Yin TP,Cai L,Xing Y,Yu J,Li XJ,Mei RF,Ding ZT

    更新日期:2016-06-01 00:00:00

  • New cytotoxic steroids from the fruits of Syzygium siamense.

    abstract::A new sterol, stigmast-5-ene-3beta,17alpha-diol (1), together with six known compounds, stigmast-5-ene-3beta-yl formate (2), stigmast-5-ene-3beta,7alpha-diol (3), stigmast-5-ene-7alpha-methoxy-3beta-ol (4), stigmast-5-ene-3-one (5), 3beta-sitostanol (6), and 3beta-sitosterol (7), was isolated from the fruits of Syzygi...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286021003762028

    authors: Chumkaew P,Kato S,Chantrapromma K

    更新日期:2010-05-01 00:00:00

  • Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.

    abstract::Pharmacochemistry and integrated pharmacokinetics of six alkaloids (groenlandicine, berberine, palmatine, epiberberine, jatrorrhizine, and columbamine) after oral administration of Huang-Lian-Jie-Du-Tang (HLJDT) decoction were investigated in this paper. The method of plasma pharmacochemistry was applied to predict th...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2014.913577

    authors: Ma ZT,Yang XW,Zhang Y,Liu JX

    更新日期:2014-01-01 00:00:00

  • Two new compounds from Aconitum tanguticum.

    abstract::A phytochemical investigation on the whole plant of Aconitum tanguticum (Ranunculaceae) resulted in the isolation and characterization of two new phenylpropanoid glycosides (1 and 2). Their structures were elucidated as 4-hydroxyphenethoxy-8-O-β-d-[6-O-(4-O-β-d-glucopyranosyl)-sinapoyl]-glucopyranoside (1) and 3,4-dim...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2014.904292

    authors: Li YR,Xu L,Li C,Wang ZM,Yang LX

    更新日期:2014-01-01 00:00:00

  • Synthesis of chrysin derivatives and screening of antitumor activity.

    abstract::A series of aromatic or long-chain chrysin derivatives (1-10) were synthesized by esterification of chrysin and acyl chloride. The chemical structures of these compounds were determined by mass spectrum (MS), 1H NMR, and 13C NMR spectra. Though aromatic chrysin derivatives (1-9) with a rigid structure were hard to dis...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2019.1586677

    authors: Chen N,Wang R,Lu LJ,Yan LJ,Bai LL,Fu Y,Wang Y,Peng DQ,Chen X,Wang CH,Li J,Zhao K

    更新日期:2020-05-01 00:00:00

  • Two new triterpenes from the roots of Pfaffia glomerata.

    abstract::Pfaffia paniculata is a commercialized dietary supplement used as the substitute for the Asian ginseng in Brazil. We conducted the systematic isolation of the EtOAc fraction with anti-inflammatory effect and two new triterpenoids, along with 26 known compounds were characterized by means of MS and NMR analysis. Intere...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2018.1446949

    authors: Lian L,Feng Y,Li YW,Bei B,Tang YT,Wang H,Feng QM,Chen G

    更新日期:2019-05-01 00:00:00

  • New xanthone glycosides from Securidaca inappendiculata.

    abstract::Three new xanthone glycosides, securixanside A (1), securixanside B (2), and securixanside C (3) were isolated from the stems of Securidaca inappendiculata. These compounds were characterized by spectrometric and chemical methods, including FABMS and one- and two-dimensional NMR experiments. ...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020290027434

    authors: Yang XD,An N,Xu LZ,Yang SL

    更新日期:2002-06-01 00:00:00

  • Two new sesquiterpene derivatives from Chinese eaglewood.

    abstract::Two new sesquiterpene derivatives, (+)-8β-hydroxy-longicamphenylone (1) and 11β-hydroxy-13-isopropyl-dihydrodehydrocostus lactone (2), were isolated from Chinese eaglewood. Their structures were elucidated on the basis of spectroscopic analyses including HR-ESI-MS, (1)H and (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC,...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2012.704910

    authors: Yang L,Qiao LR,Zhang JJ,Dai JG,Guo SX

    更新日期:2012-01-01 00:00:00

  • Two new acetylated flavan glycosides from rhizomes of the fern Abacopteris penangiana.

    abstract::Two new acetylated flavan glycosides (2S,4R)-4,5,7-trihydroxy-4'-methoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (1) and (2S,4R)-5,7-dihydroxy-4,4'-dimethoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (2) were isolated from the rhizomes of Abacopteris ...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2010.525744

    authors: Zhao ZX,Ruan JL,Jin J,Zhu CC,Lin CZ

    更新日期:2010-12-01 00:00:00

  • Anticancer agents from marine sponges.

    abstract::Marine sponges are currently one of the richest sources of anticancer active compounds found in the marine ecosystems. More than 5300 different known metabolites are from sponges and their associated microorganisms. To survive in the complicated marine environment, most of the sponge species have evolved chemical mean...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章,评审

    doi:10.1080/10286020.2014.970535

    authors: Ye J,Zhou F,Al-Kareef AM,Wang H

    更新日期:2015-01-01 00:00:00

  • Toxicokinetics and toxicity of potassium 2-(1-hydroxypentyl)-benzoate in beagle dogs.

    abstract::Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) is a prodrug of 3-n-butylphthalide (dl-NBP) for treatment of cerebral ischemic stroke in China, which undergoes lactonization to form dl-NBP in plasma. And, the phase II-III clinical trial of dl-PHPB has been approved by China Food and Drug Administration (CFDA) in 2013...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2017.1302940

    authors: Li J,Wang XL,Wang AP,Xu SF,Jin HT

    更新日期:2017-04-01 00:00:00

  • Spiroalkaloids from Shensong Yangxin capsule.

    abstract::Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These co...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2015.1047354

    authors: Ding B,Dai Y,Hou YL,Yao XS

    更新日期:2015-05-01 00:00:00

  • Chemical constituents from the roots of Feroniella lucida.

    abstract::A new furanocoumarin named lucidafuranocoumarin A (7) together with 13 known coumarins (1-6, 8-14) and four known alkaloids (15-18) was isolated from the roots of Feroniella lucida. Their structures were elucidated on the basis of spectroscopic analysis. Some of the isolates were evaluated for their biological activit...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2011.572878

    authors: Sripisut T,Cheenpracha S,Laphookhieo S

    更新日期:2011-06-01 00:00:00

  • Chemical constituents of the stems of Ephedra sinica.

    abstract::A new naphthalene derivative, 1-methyl-2,3-methylenedioxy-6-naphthalenecarboxylic acid methyl ester (1), and a new alkaloid, ( +/- )-1-phenyl-2-imido-1-propanol (2), together with the four known compounds, ephedrine, pseudoephedrine, N-methylephedrine, and 6-methoxykynurenic acid, have been isolated from the stems of ...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020802573552

    authors: Zhao W,Deng AJ,Du GH,Zhang JL,Li ZH,Qin HL

    更新日期:2009-01-01 00:00:00

  • Two new illudin type sesquiterpenoids from cultures of Phellinus tuberculosus and Laetiporus sulphureus.

    abstract::Chemical investigation on the cultures of Phellinus tuberculosus and Laetiporus sulphureus lead to the isolation of two new illudin-type sesquiterpenoids (phellinuin J and sulphureuine A). Their structures were elucidated by 1D, 2D NMR and MS spectroscopic data. These compounds were purposely evaluated for their cytot...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2015.1040774

    authors: He JB,Tao J,Miao XS,Feng YP,Bu W,Dong ZJ,Li ZH,Feng T,Liu JK

    更新日期:2015-01-01 00:00:00

  • An efficient enantioselective synthesis of (S)-α-methyl-serine methyl ester hydrochloride via asymmetrically catalyzed amination.

    abstract::We present the synthesis of enantiomerically pure (S)-α-methyl-serine methyl ester hydrochloride from 2-methyl-3-((4-(trifluoromethyl)benzyl)oxy)propanal and di-p-chlorobenzyl azodicarboxylate via asymmetrically catalyzed amination with naphthylalanine derivative catalyst. The application of the organocatalyst of D-3-...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020.2019.1634058

    authors: Xiao Q,Tang YF,Xie P

    更新日期:2020-01-01 00:00:00

  • Ether-soluble resin glycosides from the roots of Ipomoea batatas.

    abstract::Two new resin glycosides, batataosides I (1) and II (2), and five known compounds, friedelin (3), scopoletin (4), octadecyl caffeate (5), beta-sistosterol (6) and daucosterol (7), were isolated from the roots of Ipomoea batatas. Their structures have been determined based on the chemical and spectral data. Batataoside...

    journal_title:Journal of Asian natural products research

    pub_type: 杂志文章

    doi:10.1080/10286020701604839

    authors: Yin YQ,Kong LY

    更新日期:2008-03-01 00:00:00