A new 3,4-seco-labdane diterpenoid with inhibitory activity against the production of nitric oxide from the leaves of Callicarpa nudiflora.

Abstract:

:A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1) exerted inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by lipopolysaccharide.

journal_name

J Asian Nat Prod Res

authors

Zhang L,Liu MS,Huang J,Li GY,Zhang C,Dong L,Zhang K,Wang JH

doi

10.1080/10286020.2013.841675

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

216-21

issue

2

eissn

1028-6020

issn

1477-2213

journal_volume

16

pub_type

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