A novel oxybis cresol verticilatin with highly varying degrees of biological activities from the insect pathogenic fungus Paecilomyces verticillatus.

Abstract:

:A novel oxybis cresol compound named verticilatin (1), together with two known compounds, 5-methylresorcinol (2) and 2,4-dihydroxy-3,6-dimethylbenzaldehyde (3), was isolated from cultures of the insect pathogenic fungi Paecilomyces verticillatus. The structures of compounds were determined by extensive spectroscopic analysis of HR-ESI-MS and 1D and 2D NMR including HSQC, HMBC, COSY, and ROESY. Fortunately, compound 1 exhibited significant inhibitory activities against CDC25B, cathepsin B, MEG2, and SHP2 enzyme, with IC50 values of 11.5, 3.5, 7.8, and 15 μg/ml, respectively.

journal_name

J Asian Nat Prod Res

authors

Wei PY,Li L,Yang CG,Luo DQ,Zheng ZH,Lu XH,Shi BZ

doi

10.1080/10286020.2014.959438

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1153-7

issue

12

eissn

1028-6020

issn

1477-2213

journal_volume

16

pub_type

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