Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors.

abstract：:Pseudolaric acid-B (PLAB), a diterpene acid, was isolated from the root and trunk barks of Pseudolarix kaempferi. It showed antifungal and anti-fertility effects as well as cytotoxic activities in previous studies. The present study investigates cytotoxic activity on cultured human cancer cells, inhibition on the grow...

journal_title：Journal of Asian natural products research

authors： Liu B,Chen H,Lei ZY,Yu PF,Xiong B

更新日期：2006-04-01 00:00:00

abstract：:The loss of glutamate transporter-1 (GLT-1) is associated with temporal lobe epilepsy (TLE). A recent study reported that Hsp90β interacted with GLT-1 and recruited it to 20S proteasome for degradation. Therefore, inhibiting Hsp90β may be a new strategy for treating epilepsy. So far, no studies have shown whether the ...

journal_title：Journal of Asian natural products research

authors： Peng YC,Wang S,Zhang Y,Huang LJ,Wang XL,Peng Y

更新日期：2019-09-01 00:00:00

abstract：:Two new drimane sesquiterpenoids, 11,12-dihydroxy-15-drimeneoic acid (1) and 3α,11,15-trihydroxydrimene (2), were isolated from cultures of the basidiomycete Agaricus arvensis, together with one known compound 3β,11,12-trihydroxydrimene (3). Their structures were established by means of spectroscopic analysis. ...

journal_title：Journal of Asian natural products research

authors： Zhao JY,Ding JH,Li ZH,Dong ZJ,Feng T,Zhang HB,Liu JK

更新日期：2013-01-01 00:00:00

abstract：:Isolation and structure elucidation of two new compounds, kakispyrone (1) and kakisaponin A (2), together with 11 known compounds, from the leaves of Diospyros kaki L. are described. Their cytotoxic effects against several cancer cell lines (A549, HepG2 and HT29) are also reported. ...

journal_title：Journal of Asian natural products research

authors： Chen G,Xue J,Xu SX,Zhang RQ

更新日期：2007-04-01 00:00:00

abstract：:Two new ent-kaurane diterpenoid dimers, fritillebinide D (1) and fritillebinide E (2), were isolated from bulbs of Fritillaria ebeiensis G.D. Yu et G.Q. Ji. Their structures have been determined to be ent-3beta-acetoxy-kauran-16beta, 17-acetal ent-3beta-acetoxy-16beta-kauran-17(R)-aldehyde (1) and ent-3beta-acetoxy-ka...

journal_title：Journal of Asian natural products research

authors： Ruan HL,Zhang YH,Wu JZ,Sun HD,Fujita T

更新日期：2002-12-01 00:00:00

abstract：:Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical-chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excel...

journal_title：Journal of Asian natural products research

authors： Guo CJ,Ren Y,Qin YL,Zhang Q

更新日期：2008-09-01 00:00:00

abstract：:A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and five known flavonoid glycosides (2-6) were isolated from the leaves and stems of Clausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and NMR spectroscopic d...

journal_title：Journal of Asian natural products research

authors： Cao NK,Zhu SS,Chen YM,Ma XL,Zhao MB,Li J,Tu PF,Jiang Y

更新日期：2020-08-30 00:00:00

abstract：:Barlericin, the new neolignan diglycoside, has been isolated from the n-butanol soluble sub-fraction of Barleria acanthoides along with dehydrodiconiferyl alcohol 12-O-beta-D-glucopyranoside (2), reported for the first time from the genus Barleria. Their structures have been assigned on the basis of spectral studies. ...

journal_title：Journal of Asian natural products research

authors： Karim A,Noor AT,Malik A

更新日期：2010-08-01 00:00:00

abstract：:Camellia oleifera is expected to provide alternative aglycone to synthesize some saponins similar to that from Schima superba with inhibitory activity against Magnaporthe oryzae. Eight theasapogenol galactosides were synthesized via protection of adjacent hydroxyl groups by a benzylidene for regioselective glycosylati...

journal_title：Journal of Asian natural products research

authors： Huo GH,Chen XT,Li ZM,Liu CF,Xiao DJ

更新日期：2018-02-01 00:00:00

abstract：:A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, ...

journal_title：Journal of Asian natural products research

authors： Wang MY,Yang Y,Zhou XY,Wang SS,Duan SX,Li XB

更新日期：2018-08-01 00:00:00

abstract：:Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination with chemical reactions. ...

journal_title：Journal of Asian natural products research

authors： Li HM,Wan DW,Li RT

更新日期：2015-01-01 00:00:00

abstract：:Phytochemical investigation on the leaves of Rabdosia serra led to the isolation of two new abietane diterpenoids, raserranes A (1) and B (2), and four known phenylpropanoids (3-6). Their structures were determined by spectroscopic data. Compound 1 represented the rare examples of abietane diterpenoids featuring a 16-...

journal_title：Journal of Asian natural products research

authors： Liu GL,Xu W,Liu XJ,Yan XL,Chen J

更新日期：2020-01-01 00:00:00

abstract：:A new diarylheptanoid, along with five known diarylheptanoids, was isolated from the rhizomes of Alpinia officinarum (Zingiberaceae). The structure of the new compound was determined to be trans,trans-1(3'-methoxy-4'-hydroxyphenyl)-7-phenyl-5-ol-4,6-dien-3-heptanone on the basis of spectral and chemical evidence. ...

journal_title：Journal of Asian natural products research

authors： An N,Xu LZ,Zou ZM,Yang SL

更新日期：2006-10-01 00:00:00

abstract：:Four types of piscidinol A derivatives were synthesized and evaluated their ability to inhibit HIV-1 protease to understand their structure-activity relationships. Of these tirucallane-type triterpene derivatives, an A-seco derivative (1b) moderately inhibited human immunodeficiency virus (HIV) protease (IC50 38.2 μM)...

journal_title：Journal of Asian natural products research

authors： Wei Y,Ma CM,Jiang TB,Du J,Zhou X,Liu GQ,Hattori M

更新日期：2015-01-01 00:00:00

abstract：:A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3β,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark of Aglaia angustifolia Miq. The Chemical structure of the new compou...

journal_title：Journal of Asian natural products research

authors： Hutagaol RP,Harneti D,Safari A,Hidayat AT,Supratman U,Awang K,Shiono Y

更新日期：2020-06-13 00:00:00

abstract：:Three new flavonol glycosides, kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside (1), kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (2), and kaempferol-3-O-(6-trans-p-coumaroyl)-beta-D-glucopyranosyl-(1 --> 2)-...

journal_title：Journal of Asian natural products research

authors： Li N,Li X,Meng DL,Guo YQ,Wang JH

更新日期：2006-01-01 00:00:00

abstract：:A new diterpenoid, dehydrovibsanin G (1), a new lignan, (+)-9'-O-senecioyllariciresinol (2), and six known compounds (3-8) were isolated from the branches and leaves of Viburnum odoratissimum var. odoratissimum. The structures of these compounds were elucidated by analysis of spectroscopic data. Both new compounds sho...

journal_title：Journal of Asian natural products research

authors： Li FJ,Yu JH,Wang GC,Zhang H,Yue JM

更新日期：2015-05-01 00:00:00

abstract：:Three series of sulfonate derivatives of paeonol were synthesized and screened in vitro for their anti-oomycete activity against P. capsici, respectively. Among all the compounds, 4m displayed the best promising and pronounced anti-oomycete activity against P. capsici than zoxamide, with the EC50 values of 24.51 and 2...

journal_title：Journal of Asian natural products research

authors： Tian YE,Sun D,Han XX,Yang JM,Zhang S,Feng NN,Zhu LN,Xu ZY,Che ZP,Liu SM,Lin XM,Jiang J,Chen GQ

更新日期：2020-02-03 00:00:00

abstract：:Two new neolignan glucosides named (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxyl-7'-oxo-8-4'-oxyneolignan-4-O-β-D-glucopyranoside and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-D-glucopyranosyl-4'-O-β-D-glucopyranoside, together with two small molecular peptides named 3-benzyl-6-(1-...

journal_title：Journal of Asian natural products research

authors： Yang YN,Zhang F,Feng ZM,Jiang JS,Zhang PC

更新日期：2012-01-01 00:00:00

abstract：:Phytochemical investigations of the whole plant of Stachys parviflora (Lamiaceae) resulted in the isolation of two new phenethyl alcohol glycosides. The structures of the new compounds named parviflorosides A and B were established as 2-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl-(1 --> 2)-4-O-E-caffeoyl-bet...

journal_title：Journal of Asian natural products research

authors： Ahmad VU,Arshad S,Bader S,Ahmed A,Iqbal S,Tareen RB

更新日期：2006-01-01 00:00:00

abstract：:A new sterol, stigmast-5-ene-3beta,17alpha-diol (1), together with six known compounds, stigmast-5-ene-3beta-yl formate (2), stigmast-5-ene-3beta,7alpha-diol (3), stigmast-5-ene-7alpha-methoxy-3beta-ol (4), stigmast-5-ene-3-one (5), 3beta-sitostanol (6), and 3beta-sitosterol (7), was isolated from the fruits of Syzygi...

journal_title：Journal of Asian natural products research

authors： Chumkaew P,Kato S,Chantrapromma K

更新日期：2010-05-01 00:00:00

abstract：:Ophiopogon japonicus polysaccharide (FOJ-5) from Radix ophiopogonis has shown anti-myocardial ischemic action in vitro and in vivo in our previous studies. In order to clarify the influence of chemical modifications on the action, a series of sulfated FOJ-5 (FOJ-5-S) with different substitution degrees were prepared a...

journal_title：Journal of Asian natural products research

authors： Zheng Q,Feng Y,Xu DS,Lin X,Chen YZ

更新日期：2009-01-01 00:00:00

abstract：:Samoamide A is a cyclic octapeptide rich in proline and phenylalanine residues isolated from an American Samoa marine cyanobacterium, which exhibits potent activity against H460 human non-small-cell lung cancer cells (IC50 of 1.1 μM). The first total synthesis of samoamide A was achieved by employing a strategy of a s...

journal_title：Journal of Asian natural products research

authors： Chang Q,Li YL,Zhao X

更新日期：2019-02-01 00:00:00

abstract：:Verticilliside (1), a new flavone C-glucoside, has been isolated from the ethyl acetate soluble fraction of Enicostemma verticillatum and its structure is assigned on the basis of the spectroscopic data. 5,7,4'-Trihydroxyflavone 8-C-beta-D-glucopyranoside (2) and isoorientin 3'-O-methyl ether (3) have also been isolat...

journal_title：Journal of Asian natural products research

authors： Jahan E,Perveen S,Malik A

更新日期：2009-01-01 00:00:00

abstract：:Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4-12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1-3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated f...

journal_title：Journal of Asian natural products research

authors： Li L,Xie MP,Sun H,Lu AQ,Zhang B,Zhang D,Wang SJ

更新日期：2019-10-01 00:00:00

abstract：:Two new selaginellin derivatives selaginellin P (1) and selaginellin Q (2) were isolated from Selaginella tamariscina. The structures of 1 and 2 were established as 2,4'-dihydroxy-4-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene (1) and 2,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene (2) on the basis of spectroscopic m...

journal_title：Journal of Asian natural products research

authors： Xu KP,Li J,Zhu GZ,He XA,Li FS,Zou ZX,Tan LH,Cheng F,Tan GS

更新日期：2015-01-01 00:00:00

abstract：:Two new C21 steroidal glycosides were isolated from Cynanchum wallichii Wight. Their structures were elucidated as caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-digitoxopyranoside (1) and caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-ole...

journal_title：Journal of Asian natural products research

authors： Wang D,Pan WH,Bao YR,Yang XX,Meng XS

更新日期：2014-01-01 00:00:00

abstract：:Two new acetylated flavan glycosides (2S,4R)-4,5,7-trihydroxy-4'-methoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (1) and (2S,4R)-5,7-dihydroxy-4,4'-dimethoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (2) were isolated from the rhizomes of Abacopteris ...

journal_title：Journal of Asian natural products research

authors： Zhao ZX,Ruan JL,Jin J,Zhu CC,Lin CZ

更新日期：2010-12-01 00:00:00

abstract：:Chemical examination of the liquid culture of Endomelanconiopsis endophytica A326 isolated from the Chinese folk medicine Ficus hirta resulted in the isolation of two new xyloketals named xyloketals K and L (1-2) and three known analogs (3-5) including a new natural product (5). Their structures were determined on the...

journal_title：Journal of Asian natural products research

authors： Sun ZH,Liang FL,Chen YC,Liu HX,Li HH,Zhang WM

更新日期：2016-11-01 00:00:00

abstract：:Two new glycosides named as ternatoside A (1) and ternatoside B (2), with four known constituents sternbin (3), methylparaben (4), 4-O-D-glucopyranosyl-p-coumaric acid (5) and linocaffein (6) were isolated from the roots of Ranunculus ternatus, The structures of new compounds were determined by 1D and 2D NMR, MS techn...

journal_title：Journal of Asian natural products research

authors： Tian JK,Sun F,Cheng YY

更新日期：2006-01-01 00:00:00