Abstract:
:Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical-chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excellent inhibiting effect on rabbit platelet aggregation induced by platelet-activating factor which is as well as ginkgolide B.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Guo CJ,Ren Y,Qin YL,Zhang Qdoi
10.1080/10286020802240376subject
Has Abstractpub_date
2008-09-01 00:00:00pages
989-92issue
9-10eissn
1028-6020issn
1477-2213pii
905239832journal_volume
10pub_type
杂志文章abstract::Two new meroterpenes, guignardone D (1) and guignardone E (2), were isolated from endophytic fungus A1 of Scyphiphora hydrophyllacea Gaertn. F. Their structures were established based on spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY, HMBC, and ROESY). ...
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abstract::Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination with chemical reactions. ...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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abstract::A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity agai...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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abstract::Pueraria lobata flower is a medicinal herb for treating intoxication, hepatic, and gastrointestinal tract lesions induced by alcohol. This study aims to investigate the isoflavonoid glycosides in P. lobata flowers. Two new isoflavone compounds were isolated from the extract of P. lobata flowers. Their structures were ...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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abstract::Microbial transformation of oleanolic acid (1) was carried out. Six transformed products (2-7) from 1 by Alternaria longipes and three transformed products (8-10) from 1 by Penicillium adametzi were isolated. Their structures were elucidated as 2α,3α,19α-trihydroxy-ursolic acid-28-O-β-d-glucopyranoside (2), 2α,3β,19α-...
journal_title:Journal of Asian natural products research
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abstract::Ten (1-10) irritant and mild co-carcinogenic diterpene esters were isolated from the latex of Euphorbia cauducifolia L. using bioassay-guided countercurrent distribution and other chromatographic techniques. The isolated compounds were characterized on the basis of spectroscopic results and mass measurements. As an ou...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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abstract::The loss of glutamate transporter-1 (GLT-1) is associated with temporal lobe epilepsy (TLE). A recent study reported that Hsp90β interacted with GLT-1 and recruited it to 20S proteasome for degradation. Therefore, inhibiting Hsp90β may be a new strategy for treating epilepsy. So far, no studies have shown whether the ...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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abstract::Phytochemical investigation on the whole plants of Iris japonica led to the isolation of four new aromatic glycosides. Their structures including the absolute configurations were determined by spectroscopic and chemical methods as (-)-4-hydroxy-3-methoxy acetophenone 4-O-β-d-{6-O-[4-O-(7R,8S)-(4-hydroxy-3-methoxypheny...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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abstract::Phytochemical investigations of the whole plant of Stachys parviflora (Lamiaceae) resulted in the isolation of two new phenethyl alcohol glycosides. The structures of the new compounds named parviflorosides A and B were established as 2-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl-(1 --> 2)-4-O-E-caffeoyl-bet...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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