Abstract:
:Epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH) have been associated with ischemic stroke. Salvianolic acid A (SAA) is proved to display potent cerebroprotection. However, little information is available about the link between them. This study aimed to investigate whether SAA exhibits its protective effects in rats subjected to middle cerebral artery occlusion (MCAO) through sEH and EETs. The results showed that SAA treatment ameliorated neurological deficits and reduced infarct volume. Notably, the beneficial effects of SAA were attenuated by co-administration of (14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE)), a putative selective EETs antagonist. Furthermore, SAA increased the 14,15-EET levels in the blood and brain of sham and MCAO rats. Assay for hydrolase activity showed that 1 and 3 mg/kg of SAA significantly diminished brain sEH activity of MCAO rats. A fluorescent assay in vitro indicated that SAA could inhibit recombinant human sEH activity in a concentration-dependent manner (IC(50) = 1.62 μmol/l). Immunohistochemical analysis showed that SAA at the doses of 1 and 3 mg/kg significantly decreased sEH protein expression in hippocampus CA1 region of MCAO rats. In conclusion, cerebral protection of SAA is mediated, at least in part, via inhibiting sEH to increase EETs levels.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Wang SB,Pang XB,Zhao Y,Wang YH,Zhang L,Yang XY,Fang LH,Du GHdoi
10.1080/10286020.2012.723200subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1084-92issue
11eissn
1028-6020issn
1477-2213journal_volume
14pub_type
杂志文章abstract::A new p-coumaroylated santalane-type sesquiterpenoid, 8-p-coumaroyl-α-santalene (1), a new p-coumaroylated oplopanane-type sesquiterpenoid, 8-β-p-coumaroyl-oplopanone (2), and three known p-coumaroylated humulene-type sesquiterpenoids (3-5) were isolated from the ethanol extract of the whole herbs of Pilea cavaleriei....
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2017.1320990
更新日期:2018-02-01 00:00:00
abstract::Two new lignans named spicatolignan A (1) and spicatolignan B (2) have been isolated from the whole herbs of Mentha spicata L. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020500384641
更新日期:2007-04-01 00:00:00
abstract::A novel 2,3-secoaromadendrane-type sesquiterpenoid metabolite, psilosamuiensin A (1), was isolated from the broth of Psilocybe samuiensis. The structure of psilosamuiensin A was established by spectroscopic data and its configurations were confirmed by single crystal X-ray crystallographic analysis. This is the first ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020802435794
更新日期:2009-01-01 00:00:00
abstract::Two new 3,4-seco-lanostane-type triterpenes, named as 15α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1), 5α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid 3-methyl ester (2), and one new lanostane triterpene 15α-acetoxylhydroxytrametenolic acid (3) together with a known one versisponic aci...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1027694
更新日期:2015-01-01 00:00:00
abstract::A new natural compound, dehydrophyllodulcin (1) was isolated from the tubers of Scirpus yagara, together with 11 known compounds. Among them, compounds 2, 5-8, and 10-12 were isolated from this plant for the first time. (1)H NMR, (13)C NMR, and 2D NMR data of compound 1 are first reported in this article, though it wa...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2016.1158166
更新日期:2016-08-01 00:00:00
abstract::Three new eremophilane-type sesquiterpenoids, alashanoids K-M (1-3), and one known analogue (4) were isolated from the peeled stems of Syringa pinnatifolia. All the compounds were isolated from the genus Syringa for the first time. Structures of these compounds were established using 1D and 2D NMR and MS data. The abs...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2019.1694516
更新日期:2019-12-01 00:00:00
abstract::A novel tetraterpenoid named methyl tortuoate C (1) has been isolated from the soft coral Sarcophyton tortuosum Tix.-Dur. The structure of 1 was determined on the basis of spectroscopic methods. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020600604344
更新日期:2007-04-01 00:00:00
abstract::Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined wit...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1117452
更新日期:2016-01-01 00:00:00
abstract::Two new homoisoflavonoids, ( ± )-5,7-dihydroxy-8-methyl-3-(2',4'-dihydroxybenzyl) chroman-4-one (1) and ( ± )-5,7-dihydroxy-6,8-dimethyl-3-(2',4'-dihydroxybenzyl) chroman-4-one (2), along with two known homoisoflavonoids, 5,7-dihydroxy-6-methyl-3-(2',4'-dihydroxybenzyl)chroman-4-one (3) and disporopsin (4), were isola...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.930444
更新日期:2014-01-01 00:00:00
abstract::Activity-guided fractionation of Neosinocalamus affinis leaves led to obtain two new flavonoids, 4'-O-((7″R,8″S)-8″-guaiacylglyceryl)-pleioside B (9) and apigenin 6-C-β-d-fucopyranosyl-7-O-β-d-glucopyranoside (10) along with eight known compounds. Their structures were elucidated on the basis of spectroscopic data (UV...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.981164
更新日期:2015-01-01 00:00:00
abstract::Four new compounds, uvamalols A-C and uvarimacrophin A, have been isolated from the roots of Uvaria macrophylla. Their structures have been elucidated by spectroscopic methods. The relative configurations of uvamalols A-C have been established by NOE experiments, and the relative stereochemistry of uvarimacrophin A in...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020412331286524
更新日期:2005-10-01 00:00:00
abstract::From the EtOH extract of the flowers of Camellia nitidissima Chi, a new acylated flavonoid glycoside, quercetin 7-O-(6"-O-E-caffeoyl)-β-D-glucopyranoside (1), has been isolated, together with three known flavonoids: quercetin (2), quercetin 3-O-β-D-glucopyranoside (3), and quercetin 7-O-β-D-glucopyranoside (4). Their ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2012.691475
更新日期:2012-01-01 00:00:00
abstract::Two new metabolites, pyrenocine J (1) and pyrenochaetic acid D (2), together with two known metabolites, pyrenocine A (3) and pyrenochaetic acid A (4), were isolated from a soil fungus, Curvularia affinis strain HS-FG-196. Their structures were established by extensive spectroscopic analysis. Compound 1 showed cytotox...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2012.713351
更新日期:2012-01-01 00:00:00
abstract::A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2017.1383397
更新日期:2018-08-01 00:00:00
abstract::A new C20-diterpenoid alkaloid handelidine (1) and twenty-seven known alkaloids (2-28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C20-diterpenoid alkaloids with vicinal-triol system a...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1114473
更新日期:2016-06-01 00:00:00
abstract::A new compound, named trollioside, together with nine known compounds, proglobeflowery acid, isoswertisin, isoswertiajaponin, cirsimaritin, veratric acid, vitexin, orientin, beta-sitosterol and daucosterol, were isolated from the ethanol extract of the dried flowers of Trollius chinensis Bunge. The isolation and struc...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/1028602031000147393
更新日期:2004-06-01 00:00:00
abstract::Two new selaginellin derivatives selaginellin P (1) and selaginellin Q (2) were isolated from Selaginella tamariscina. The structures of 1 and 2 were established as 2,4'-dihydroxy-4-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene (1) and 2,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene (2) on the basis of spectroscopic m...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1016001
更新日期:2015-01-01 00:00:00
abstract::Five labdane-type diterpenes, vitexilactone (1), (rel 5S,6R,8R,9R,10S)-6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (2), rotundifuran (3), vitetrifolin D (4), and vitetrifolin E (5), have been isolated from Vitex trifolia L., a Chinese folk medicine used to treat cancers, as new cell cycle inhibitors and apoptosis in...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020310001617165
更新日期:2005-04-01 00:00:00
abstract::A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, H...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.885506
更新日期:2014-01-01 00:00:00
abstract::Six thiophenes were isolated and purified from ethanol extract of the roots of Echinops latifolius Tausch. Their structures were identified on the basis of spectral data. Among them, 5-(3-hydroxmethyl-3-isovaleroyloxyprop-1-ynyl)-2,2'-bithiophene (6) is a new compound, and 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2'...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020500176724
更新日期:2006-10-01 00:00:00
abstract::Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most s...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020801948334
更新日期:2008-05-01 00:00:00
abstract::Three new compounds, namely massonside C (1), massonianoside F (2), and 3, 8-dimethyl- herbacetin-7-O-β-D-glucopyranoside (3), together with five known compounds (4-8), were isolated from the fresh needles of Pinus massoniana. Their structures were established by 1D, 2D NMR, HRMS and comparison with the literature dat...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2019.1642331
更新日期:2020-08-01 00:00:00
abstract::A new ester, 2-(4'-hydroxyphenyl)ethyl dotriacontanoate (1), and a new inseparable mixture of octacosan-1,28-dioldiferulate and triacontan-1,30-dioldiferulate (2) were isolated from the stem barks of Stereospermum acuminatissimum, along with 24 known compounds including 4 triterpenoids, 11 anthraquinones, 2 lignans, 3...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.619182
更新日期:2011-12-01 00:00:00
abstract::Three new xanthone glycosides, securixanside A (1), securixanside B (2), and securixanside C (3) were isolated from the stems of Securidaca inappendiculata. These compounds were characterized by spectrometric and chemical methods, including FABMS and one- and two-dimensional NMR experiments. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020290027434
更新日期:2002-06-01 00:00:00
abstract::A new triterpenoid saponin named clematichinenoside AR(2), along with the six known compounds, was isolated and characterized from Clematis chinensis Osbeck (Ranunculaceae), a commonly used traditional Chinese medicine with anti-inflammatory and anti-rheumatoid activities. The structure of the new saponin was elucidat...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020902867268
更新日期:2009-01-01 00:00:00
abstract::Two new 2-(2-phenylethyl)chromone derivatives (1-2) were isolated from the ethyl acetate extract of artificial agarwood induced by holing method originating from Aquilaria sinensis (Lour.) Gilg, and they were isolated from this genus for the first time. The structures of these two new compounds were elucidated by exte...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2020.1860029
更新日期:2020-12-18 00:00:00
abstract::Two new neolignan glucosides named (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxyl-7'-oxo-8-4'-oxyneolignan-4-O-β-D-glucopyranoside and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-D-glucopyranosyl-4'-O-β-D-glucopyranoside, together with two small molecular peptides named 3-benzyl-6-(1-...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2012.729050
更新日期:2012-01-01 00:00:00
abstract::Eight tetranortriterpenoids (1-8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1β-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR an...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.938060
更新日期:2014-01-01 00:00:00
abstract::Two new drimane sesquiterpenoids, 11,12-dihydroxy-15-drimeneoic acid (1) and 3α,11,15-trihydroxydrimene (2), were isolated from cultures of the basidiomycete Agaricus arvensis, together with one known compound 3β,11,12-trihydroxydrimene (3). Their structures were established by means of spectroscopic analysis. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.764287
更新日期:2013-01-01 00:00:00
abstract::A new minor sesquiterpene lactone glucoside, ixerin ZA (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6'-(p-metheoxyphenylacetyl)]-beta-glucopyranoside on the basis of sp...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020500532140
更新日期:2006-09-01 00:00:00