Abstract:
:A new natural compound, dehydrophyllodulcin (1) was isolated from the tubers of Scirpus yagara, together with 11 known compounds. Among them, compounds 2, 5-8, and 10-12 were isolated from this plant for the first time. (1)H NMR, (13)C NMR, and 2D NMR data of compound 1 are first reported in this article, though it was synthesized in 1996. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and compared with literature information. Moreover, the anti-inflammatory effects of compounds 1, 3, 4, 6, and 9 against inflammatory cytokines production in Lipopolysaccharide - or Pam3csk4-stimulated macrophage RAW264.7 cells were evaluated by Enzyme-linked immunosorbent assay. And these compounds significantly inhibited the tumor necrosis factor (TNF)-α, interleukin (IL)-6 productions in RAW264.7 cells, with IC50 values less than 20 μM.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Dong SH,Zhang JF,Tang YM,Li J,Xiang YR,Liang QLdoi
10.1080/10286020.2016.1158166subject
Has Abstractpub_date
2016-08-01 00:00:00pages
791-7issue
8eissn
1028-6020issn
1477-2213journal_volume
18pub_type
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