Chemical constituents from the tubers of Scirpus yagara and their anti-inflammatory activities.

Abstract:

:A new natural compound, dehydrophyllodulcin (1) was isolated from the tubers of Scirpus yagara, together with 11 known compounds. Among them, compounds 2, 5-8, and 10-12 were isolated from this plant for the first time. (1)H NMR, (13)C NMR, and 2D NMR data of compound 1 are first reported in this article, though it was synthesized in 1996. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and compared with literature information. Moreover, the anti-inflammatory effects of compounds 1, 3, 4, 6, and 9 against inflammatory cytokines production in Lipopolysaccharide - or Pam3csk4-stimulated macrophage RAW264.7 cells were evaluated by Enzyme-linked immunosorbent assay. And these compounds significantly inhibited the tumor necrosis factor (TNF)-α, interleukin (IL)-6 productions in RAW264.7 cells, with IC50 values less than 20 μM.

journal_name

J Asian Nat Prod Res

authors

Dong SH,Zhang JF,Tang YM,Li J,Xiang YR,Liang QL

doi

10.1080/10286020.2016.1158166

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

791-7

issue

8

eissn

1028-6020

issn

1477-2213

journal_volume

18

pub_type

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