Abstract:
:Glycyrrhetinic acid (GA) is an active component of licorice root that has long been used as a herbal medicine for the treatment of peptic ulcer, hepatitis, and pulmonary and skin diseases in Asia and Europe. In this study, we analyzed the effect of GA extracted from Glycyrrhiza uralensis Fisch. on the expression of Toll-like receptors (TLRs) that play key roles in regulating the innate immune response against invading pathogens. Stimulation of Ana-1 murine macrophages with GA induced a significant dose-dependent expression of TLR-4, and its mRNA expression that increased from 3-h post-treatment was approximately fivefold over the level in the mock-treated cells. No endotoxin contamination contributed to the GA-induced TLR-4 expression, because polymyxin B treatment did not alter the upregulated expression of TLR-4 in GA-treated cells. Several molecules, such as myeloid differentiation factor 88, interferon-β, and interleukin-6, which are involved in the TLR-4 downstream signaling pathway, were upregulated significantly in response to GA stimulation. Our findings demonstrate that GA is able to induce the expression of TLR-4 and activate its downstream signaling pathway.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Peng LN,Li L,Qiu YF,Miao JH,Gao XQ,Zhou Y,Shi ZX,Xu YL,Shao DH,Wei JC,Ma ZYdoi
10.1080/10286020.2011.603305subject
Has Abstractpub_date
2011-10-01 00:00:00pages
942-50issue
10eissn
1028-6020issn
1477-2213journal_volume
13pub_type
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