Abstract:
:Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Guan SH,Xia JM,Yang M,Wang XM,Liu X,Guo DAdoi
10.1080/10286020802016297subject
Has Abstractpub_date
2008-07-01 00:00:00pages
705-10issue
7-8eissn
1028-6020issn
1477-2213pii
901453466journal_volume
10pub_type
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