Abstract:
:Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9' positions of aryl-tetralin lignan skeleton. All nine compounds were assayed for inhibitory effects against nitric oxide and pro-inflammatory cytokines TNF-α and IL-6 release in LPS-induced RAW 246.7 macrophages, while no significant activities were observed for the evaluated compounds.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Gao YP,Shen YH,Xu XK,Tian JM,Zeng HW,Lin S,Liu CM,Zhang WDdoi
10.1080/10286020.2014.898634subject
Has Abstractpub_date
2014-01-01 00:00:00pages
724-9issue
7eissn
1028-6020issn
1477-2213journal_volume
16pub_type
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