Two novel lignans from Gaultheria yunnanensis.

Abstract:

:Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9' positions of aryl-tetralin lignan skeleton. All nine compounds were assayed for inhibitory effects against nitric oxide and pro-inflammatory cytokines TNF-α and IL-6 release in LPS-induced RAW 246.7 macrophages, while no significant activities were observed for the evaluated compounds.

journal_name

J Asian Nat Prod Res

authors

Gao YP,Shen YH,Xu XK,Tian JM,Zeng HW,Lin S,Liu CM,Zhang WD

doi

10.1080/10286020.2014.898634

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

724-9

issue

7

eissn

1028-6020

issn

1477-2213

journal_volume

16

pub_type

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