Abstract：
:Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) is a prodrug of 3-n-butylphthalide (dl-NBP) for treatment of cerebral ischemic stroke in China, which undergoes lactonization to form dl-NBP in plasma. And, the phase II-III clinical trial of dl-PHPB has been approved by China Food and Drug Administration (CFDA) in 2013. In this study, a toxicity and toxicokinetics evaluation of dl-PHPB was performed using beagle dogs at specially high-dose 108 mg/kg/day (65-fold higher than humans at MHRD) for 4 weeks by intravenous administration, with a 3-week recovery period. And the plasma concentrations of dl-PHPB along with its metabolite dl-NBP were determined by HPLC-UV method. The results showed that dl-PHPB was quickly metabolized into dl-NBP, and no significant accumulation was observed. A slight to moderate behavior-associated toxicity was revealed in the process of delivery; and recovered to normal at the end of administration. Changes in the blood hematological profiles included significantly increased NEUT levels and lower LYM% content. Meanwhile, a notable increase in TG content was also observed in the serum biochemical parameters at 4-week post-exposure. These findings were reversible during the recovery period. The information from these studies would be taken into consideration for the interpretation of toxicology findings and provide a reference for clinical safety assessment.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Li J,Wang XL,Wang AP,Xu SF,Jin HTdoi
10.1080/10286020.2017.1302940subject
Has Abstractpub_date
2017-04-01 00:00:00pages
388-401issue
4eissn
1028-6020issn
1477-2213journal_volume
19pub_type
杂志文章abstract：:Eight tetranortriterpenoids (1-8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1β-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR an...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2014.938060
更新日期：2014-01-01 00:00:00
abstract：:Two new apianen lactones, named as guanyeliaoine I (1) and guanyeliaoine II (2), have been isolated along with seven known compounds from Polygonum perforliatum L. (Chinese name "Guanyeliao", Berberidaceae). Their structures were deduced on the basis of spectral data and chemical methods. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/1028602042000324844
更新日期：2007-03-01 00:00:00
abstract：:A phytochemical investigation on the whole plant of Aconitum tanguticum (Ranunculaceae) resulted in the isolation and characterization of two new phenylpropanoid glycosides (1 and 2). Their structures were elucidated as 4-hydroxyphenethoxy-8-O-β-d-[6-O-(4-O-β-d-glucopyranosyl)-sinapoyl]-glucopyranoside (1) and 3,4-dim...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2014.904292
更新日期：2014-01-01 00:00:00
abstract：:Two new polyketides, 3,11-dihydroxy-6,8-dimethyldodecanoic acid (1) and trichopyrone B (2), together with two known polyketides, sorbicillin (3) and penicillone A (4), have been isolated from the cultures broth of the fungus Penicillium decumbens. Their structures were elucidated by extensive spectroscopic analysis. A...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2018.1424139
更新日期：2018-05-01 00:00:00
abstract：:3,7-Dimethyl-7-hydroxy-2-octen-1,6-olide and 3,7-dimethyl-2,6-octadien-1,6-olide, the natural bioactive compounds isolated from the fruit of Litsea cubeba and the liverwort Plagiochila rutilans, were totally synthesized using easily available cis-geraniol as raw material in short, convenient, and low-cost, five-step r...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2013.803474
更新日期：2013-01-01 00:00:00
abstract：:Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020802016297
更新日期：2008-07-01 00:00:00
abstract：:Ten (1-10) irritant and mild co-carcinogenic diterpene esters were isolated from the latex of Euphorbia cauducifolia L. using bioassay-guided countercurrent distribution and other chromatographic techniques. The isolated compounds were characterized on the basis of spectroscopic results and mass measurements. As an ou...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2010.489039
更新日期：2010-07-01 00:00:00
abstract：:A new amide alkaloid, N-(3',4',5'-trimethoxy-cis-cinnamoyl)pyrrolidine (1), named sarmentomicine was isolated from the ethanol extract of the leaves of Malayan Piper sarmentosum, together with two known phenylpropanoids. Their structures were elucidated on the basis of spectroscopic analysis. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020903058933
更新日期：2009-08-01 00:00:00
abstract：:Methyl tortuoate D (1), together with five other known related bis-cembranoids, was isolated from Hainan soft coral Sarcophyton tortuosum. The structure of methyl tortuoate D (1a), firstly isolated and reported by Li et al. from the title organism, was corrected as 1 by an extensive analysis of its one-dimensional and...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2013.787988
更新日期：2013-01-01 00:00:00
abstract：:Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These co...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2015.1047354
更新日期：2015-05-01 00:00:00
abstract：:A new angular dihydropyrancoumarin named wulongensin A, along with five known coumarins, (-)-anomalin, umbelliferone, (-)-smyrinol, 3'(S),4'(S)-disenecioyloxy-3',4'-dihydroseselin, (+)-trans-khellactone, was isolated from the root of Peucedanum wulongense. The structure of wulongensin A was established as 3'(R)-angelo...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/1028602031000082034
更新日期：2003-09-01 00:00:00
abstract：:Four new minor taxanes (1-4) have been isolated from Ts-19 cell cultures of Taxus chinensis together with five known taxanes (5-9) by silica gel chromatography combined with semi-preparative HPLC chromatography. On the basis of the analyses of the chemical and spectroscopic (IR, MS, 1D, and 2D NMR) data, the structure...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020902882143
更新日期：2009-06-01 00:00:00
abstract：:Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination with chemical reactions. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2014.1001379
更新日期：2015-01-01 00:00:00
abstract：:A novel 2,3-secoaromadendrane-type sesquiterpenoid metabolite, psilosamuiensin A (1), was isolated from the broth of Psilocybe samuiensis. The structure of psilosamuiensin A was established by spectroscopic data and its configurations were confirmed by single crystal X-ray crystallographic analysis. This is the first ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020802435794
更新日期：2009-01-01 00:00:00
abstract：:A new pyranoxanthone, venuloxanthone (1), was isolated from the stem bark of Calophyllum venulosum, together with three other xanthones, tovopyrifolin C (2), ananixanthone (3) and caloxanthone I (4), along with two common triterpenes, friedelin (5) and lupeol (6). The structures of these compounds were identified usin...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2015.1047353
更新日期：2015-01-01 00:00:00
abstract：:A new selaginellin derivative, selaginellin M (1), together with one known compound, selaginellin E (2), was isolated from Selaginella pulvinata. The structure of the new compound was elucidated and named as (R,S)-4-((4'-hydroxy-4-((2-hydroxyethoxy)methyl))-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)me...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2011.617304
更新日期：2011-10-01 00:00:00
abstract：:Phytochemical investigation of the roots of Arisaema jacquemontii led to the isolation of two new triterpenoids, which were characterized by NMR, IR, and MS spectra as 30-nor-lanost-5-ene-3beta-ol (1) and 30-norlanost-5-ene-3-one (2). ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020903505057
更新日期：2010-02-01 00:00:00
abstract：:During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50 = 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell line...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2016.1228633
更新日期：2017-05-01 00:00:00
abstract：:A series of piplartine derivatives were synthesized via Baylis-Hillman reaction and evaluated for anticancer and antibacterial activities. The cytotoxicity of these compounds was examined in two different human tumor cell lines, IMR-32 and HeLa. The antibacterial activity was examined in Staphylococcus aureus and Pseu...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2013.769965
更新日期：2013-01-01 00:00:00
abstract：:Two new lignan glycosides forsythiayanoside A (1) and forsythiayanoside B (2), one new stereoisomer of lignan glycoside (+)-8-hydroxyepipinoresinol-4-O-β-D-glucopyranoside (3), together with seven known compounds (4-10), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. Compounds 4 and 10 were isolate...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2014.917631
更新日期：2014-01-01 00:00:00
abstract：:The protective effect of rhein lysinate (RHL) on Alzheimer's disease (AD) was explored in senescence-accelerated mouse prone-8 (SAMP8) mice. SAMP8 mice without treatment were used as the AD-positive control, and senescence-accelerated-resistant mice were used as the AD-negative control. In this study, 4-month-old male...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2013.800972
更新日期：2013-07-01 00:00:00
abstract：:Two new 3,4-seco-lanostane-type triterpenes, named as 15α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1), 5α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid 3-methyl ester (2), and one new lanostane triterpene 15α-acetoxylhydroxytrametenolic acid (3) together with a known one versisponic aci...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2015.1027694
更新日期：2015-01-01 00:00:00
abstract：:Two new drimane sesquiterpenoids, 11,12-dihydroxy-15-drimeneoic acid (1) and 3α,11,15-trihydroxydrimene (2), were isolated from cultures of the basidiomycete Agaricus arvensis, together with one known compound 3β,11,12-trihydroxydrimene (3). Their structures were established by means of spectroscopic analysis. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2013.764287
更新日期：2013-01-01 00:00:00
abstract：:Two new lignans named neourticol A (1) and neourticol B (2), together with seven known compounds (3-9), were isolated from Urticae Fissae Herba, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1 and 2 possessed the potent anti-complement and anti-inflammatory activities. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2018.1457652
更新日期：2019-06-01 00:00:00
abstract：:Verticilliside (1), a new flavone C-glucoside, has been isolated from the ethyl acetate soluble fraction of Enicostemma verticillatum and its structure is assigned on the basis of the spectroscopic data. 5,7,4'-Trihydroxyflavone 8-C-beta-D-glucopyranoside (2) and isoorientin 3'-O-methyl ether (3) have also been isolat...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020802675019
更新日期：2009-01-01 00:00:00
abstract：:Two new saponins, capilliposide G (1) and capilliposide H (2), were isolated from the whole plants of Lysimachia capillipes. Their structures were determined by 1D and 2D NMR, MS technique and chemical methods. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020500173259
更新日期：2006-07-01 00:00:00
abstract：:Four new furostanol glycosides were isolated from the flowers of Hosta plantaginea (Lam.) Aschers. On the basis of spectroscopic methods including 1D and 2D NMR experiments, their structures were elucidated as 26-O-β-d-glucopyranosyl-(25R)-22-O-methyl-5α-furostan-2α,3β,22ξ,26-tetrol 3-O-α-l-rhamnopyranosyl-(1 → 4)-O-β...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2014.998652
更新日期：2015-01-01 00:00:00
abstract：:Our current marine natural product program investigated the second metabolites of an actinomycete Streptomyces cavourensis YY01-17 originating from the Antarctic ecological niche to discover potential antitumor chemical entities. Two new compounds, along with a known compound, were isolated from the ethyl acetate extr...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/10286020.2012.762764
更新日期：2013-01-01 00:00:00
abstract：:Manuifolin Q (1), an unusual 4-aryl-substituted isoflavan, was isolated from the roots of Maackia tenuifolia. Its absolute configuration was determined as (3R,4R)-3,4-trans-7,2'-dihydroxy-4'-methoxy-4-[(2,4-dihydroxy-5-(1,1-dimethyl-2-propenyl)]-phenyl-isoflavan, on the basis of spectroscopic analysis. ...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/1028602031000119817
更新日期：2004-03-01 00:00:00
abstract：:Three new flavonol glycosides, kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside (1), kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (2), and kaempferol-3-O-(6-trans-p-coumaroyl)-beta-D-glucopyranosyl-(1 --> 2)-...
journal_title：Journal of Asian natural products research
pub_type： 杂志文章
doi：10.1080/1028602042000325627
更新日期：2006-01-01 00:00:00
