Abstract:
:A series of piplartine derivatives were synthesized via Baylis-Hillman reaction and evaluated for anticancer and antibacterial activities. The cytotoxicity of these compounds was examined in two different human tumor cell lines, IMR-32 and HeLa. The antibacterial activity was examined in Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that compounds 2b, 2e, and 2j were found to be the most active compounds, which displayed line no cytotoxicity, but G2-M cell cycle arrest in tumor cells, and showed cytostatic effects in bacteria.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Kumar JU,Shankaraiah G,Kumar RS,Pitke VV,Rao GT,Poornima B,Babu KS,Sreedhar ASdoi
10.1080/10286020.2013.769965subject
Has Abstractpub_date
2013-01-01 00:00:00pages
658-69issue
6eissn
1028-6020issn
1477-2213journal_volume
15pub_type
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