Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates.

abstract：:Seven new C14-polyacetylene glucosides codonopilodiynosides A-G (1-7) were isolated from an aqueous extract of the Codonopsis pilosula roots. Their structures were determined by spectroscopic and chemical methods as (-)-(5S,6E,12E)-tetradeca-6,12-dien-8,10-diyn-1,5,14-triol 5-O-β-D-glucopyranoside (1), (-)-(5S,6E,12E)...

journal_title：Journal of Asian natural products research

authors： Jiang YP,Liu YF,Guo QL,Jiang ZB,Xu CB,Zhu CG,Yang YC,Lin S,Shi JG

更新日期：2015-01-01 00:00:00

abstract：:Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1-5 showed growth inhibitory activi...

journal_title：Journal of Asian natural products research

authors： Cui CB,Yan SY,Cai B,Yao XS

更新日期：2002-12-01 00:00:00

abstract：:Liver is the largest metabolic organ for a wide range of endogenous and exogenous compounds and plays a crucial part in the pharmacokinetics and pharmacodynamics through various metabolic reactions. This review provides a progressive description of hepatic metabolism of herbal drugs with respect to metabolic types and...

journal_title：Journal of Asian natural products research

authors： Peng YS,Liu B,Wang RF,Zhao QT,Xu W,Yang XW

更新日期：2015-01-01 00:00:00

abstract：:Natural products are an important original source of many widely used drugs, including anti-cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural products are mainly focused on the compounds with cytotoxicity capability. The good examples include vinblastine, vincristine, the camptothec...

journal_title：Journal of Asian natural products research

authors： Hua F,Shang S,Hu ZW

更新日期：2017-04-01 00:00:00

abstract：:Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination with chemical reactions. ...

journal_title：Journal of Asian natural products research

authors： Li HM,Wan DW,Li RT

更新日期：2015-01-01 00:00:00

abstract：:Two new flavonoid alkaloids, 8-(2''-pyrrolidinone-5''-yl)-quercetin (1) and 8-(2''-pyrrolidinone-5''-yl)-isorhamnetin (2), were isolated from the herb of Senecio argunensis. Their structures were elucidated by spectral analysis. ...

journal_title：Journal of Asian natural products research

authors： Li N,Shao L,Zhang CF,Zhang M

更新日期：2008-11-01 00:00:00

abstract：:A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity agai...

journal_title：Journal of Asian natural products research

authors： Chai MY

更新日期：2020-03-01 00:00:00

abstract：:Camellia oleifera is expected to provide alternative aglycone to synthesize some saponins similar to that from Schima superba with inhibitory activity against Magnaporthe oryzae. Eight theasapogenol galactosides were synthesized via protection of adjacent hydroxyl groups by a benzylidene for regioselective glycosylati...

journal_title：Journal of Asian natural products research

authors： Huo GH,Chen XT,Li ZM,Liu CF,Xiao DJ

更新日期：2018-02-01 00:00:00

abstract：:From the roots of Securidaca inappendiculata, one new sterol glycoside securisteroside (1) has been isolated, along with two known sterols, spinasterol (2) and 3-O-beta-D-glucopyranosyl-spinasterol (3). The new sterol was characterized by chemical and spectrometric methods, including EIMS, FABMS and one- and two-dimen...

journal_title：Journal of Asian natural products research

authors： Zhang LJ,Yang XD,Xu LZ,Zou ZM,Yang SL

更新日期：2005-08-01 00:00:00

abstract：:Two new C21 steroidal glycosides were isolated from Cynanchum wallichii Wight. Their structures were elucidated as caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-digitoxopyranoside (1) and caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-ole...

journal_title：Journal of Asian natural products research

authors： Wang D,Pan WH,Bao YR,Yang XX,Meng XS

更新日期：2014-01-01 00:00:00

abstract：:A new sterol, stigmast-5-ene-3beta,17alpha-diol (1), together with six known compounds, stigmast-5-ene-3beta-yl formate (2), stigmast-5-ene-3beta,7alpha-diol (3), stigmast-5-ene-7alpha-methoxy-3beta-ol (4), stigmast-5-ene-3-one (5), 3beta-sitostanol (6), and 3beta-sitosterol (7), was isolated from the fruits of Syzygi...

journal_title：Journal of Asian natural products research

authors： Chumkaew P,Kato S,Chantrapromma K

更新日期：2010-05-01 00:00:00

abstract：:Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by ...

journal_title：Journal of Asian natural products research

authors： Guan SH,Xia JM,Yang M,Wang XM,Liu X,Guo DA

更新日期：2008-07-01 00:00:00

abstract：:Two new stemoninine-type alkaloids, stemoninine A (1) and B (2), along with two known Stemona alkaloids, bisdehydrostemoninine (3) and bisdehydrostemoninine A (4), were isolated from the roots of Stemona sessilifolia, and their structures and relative configurations were determined on the basis of spectrometric data a...

journal_title：Journal of Asian natural products research

authors： Wang P,Liu AL,Li ZH,Du GH,Qin HL

更新日期：2008-03-01 00:00:00

abstract：:Two new phthalates bis(2-ethylundecyl)phthalate and bis(2-ethyltridecyl)phthalate have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei along with one known compound β-amyrin. The structures of the two new compounds and β-amyrin were assigned on the basis of their ¹H and ¹³C NMR s...

journal_title：Journal of Asian natural products research

authors： Hussain J,Rehman NU,Hussain H,Ali L,Al-Harrasi A

更新日期：2012-01-01 00:00:00

abstract：:One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lacto...

journal_title：Journal of Asian natural products research

authors： Shi L,Tan DH,Yan TC,Jiang DH,Hou MX

更新日期：2018-02-01 00:00:00

abstract：:Chemical studies on the roots of Fraxinus rhynchophylla led to the isolation of fraxisecoside (1), a novel coumarin-secoiridoid hybrid glycoside, namely, fraxetin-8-O-[11'-methyl-oleosidyl-(7'-->6'')]-beta-D-glucopyranoside and 14 known compounds. Their structures were elucidated based on chemical evidence and spectro...

journal_title：Journal of Asian natural products research

authors： Xiao K,Song QH,Zhang SW,Xuan LJ

更新日期：2008-01-01 00:00:00

abstract：:Investigation of the constituents from the stem barks of Garcinia multiflora has yielded two new compounds, multiflorabiphenyl A (1) and 24-p-E-coumaroyl-tetracosanyl (E)-ferulate (2), along with 10 known compounds, friedelin (3), friedelan-3β-ol (4), α,β-amyrin (5), rheediachromenoxanthone (6), 1,7-dihydroxyxanthone ...

journal_title：Journal of Asian natural products research

authors： Jing WY,Jiang C,Ji F,Hua HM,Li ZL

更新日期：2013-11-01 00:00:00

abstract：:Two new neolignan glucosides named (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxyl-7'-oxo-8-4'-oxyneolignan-4-O-β-D-glucopyranoside and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-D-glucopyranosyl-4'-O-β-D-glucopyranoside, together with two small molecular peptides named 3-benzyl-6-(1-...

journal_title：Journal of Asian natural products research

authors： Yang YN,Zhang F,Feng ZM,Jiang JS,Zhang PC

更新日期：2012-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the exp...

journal_title：Journal of Asian natural products research

authors： Wang HQ,Hu J,Yan HY,Wu S,Li YH

更新日期：2017-11-01 00:00:00

abstract：:Mucor spinosus has been employed for the biotransformation of cinobufagin (1) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1beta-hydroxy-cinobufagin (2), 12beta-hydroxy-cinobufagin (3) and 1beta,12beta-dihydroxy-cinob...

journal_title：Journal of Asian natural products research

authors： Zhang W,Ye M,Qu GQ,Wu WY,Chen YJ,Guo DA

更新日期：2005-06-01 00:00:00

abstract：:A chemical investigation of the endemic relict shrub Tetraena mongolica led to the isolation of four new triterpenes: 11α,12α:13β,28-diepoxyoleanane-3β-yl trans-caffeate (1), 3β-hydroxy-11α,12α-epoxyoleanane-28-al (2), olean-11-en-28-al-3β-yl trans-caffeate (3), and 28-acetoxy-olean-12-en-3β-yl trans-caffeate (4). The...

journal_title：Journal of Asian natural products research

authors： Tang SA,Ding LL,Zhai HY,Qin N,Duan HQ

更新日期：2012-01-01 00:00:00

abstract：:The chemical investigation on the fruiting bodies of Amauroderma subresinosum led to the isolation of 10 compounds including 2 new ones named amaurosubresin (1) and erythro(23,24)-5α,6α-epoxyergosta-8-ene-7-one-3β,23-diol (2). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. T...

journal_title：Journal of Asian natural products research

authors： Wang Q,Wang YG,Ma QY,Huang SZ,Kong FD,Zhou LM,Dai HF,Zhao YX

更新日期：2016-11-01 00:00:00

abstract：:Three new eremophilane-type sesquiterpenoids, alashanoids K-M (1-3), and one known analogue (4) were isolated from the peeled stems of Syringa pinnatifolia. All the compounds were isolated from the genus Syringa for the first time. Structures of these compounds were established using 1D and 2D NMR and MS data. The abs...

journal_title：Journal of Asian natural products research

authors： Peng B,Zhang RF,Du BZ,Jiao SG,Zhou XC,Gao XL,Chen SY,Tu PF,Chai XY

更新日期：2019-12-01 00:00:00

abstract：:Three new compounds, namely massonside C (1), massonianoside F (2), and 3, 8-dimethyl- herbacetin-7-O-β-D-glucopyranoside (3), together with five known compounds (4-8), were isolated from the fresh needles of Pinus massoniana. Their structures were established by 1D, 2D NMR, HRMS and comparison with the literature dat...

journal_title：Journal of Asian natural products research

authors： Xiao YC,Shi ZF,Yan CQ,Tang QX,Zhao MX,Liu LT,Huang QS,Ye L,Xu K,Ke X

更新日期：2020-08-01 00:00:00

abstract：:Three new decenynol glucosides were isolated from the aerial parts of Artemisia scoparia. Their structures were determined to be 6E,8Z-decadien-4-yn-ol 1-O-β-d-glucopyranoside, 6E,8E-decadien-4-yn-ol 1-O-β-d-glucopyranoside, and 6E-decen-4-yn-ol 1-O-β-d-glucopyranoside based on extensive spectroscopic (NMR and MS) ana...

journal_title：Journal of Asian natural products research

authors： Cho JY,Park KH,Hwang DY,Lee SY,Moon JH,Ju Lee Y,Park KD,Ham KS

更新日期：2020-09-01 00:00:00

abstract：:Two new isobenzofuranone derivatives, polyphthaliside A (1) and polyphthaliside B (2), and a new isocoumarin derivative, polyisocoumarin (3), were isolated from Polygonum cuspidatum. Their structures were elucidated by detailed spectroscopic analysis and chemical methods. The cytotoxicity activity and PTP1B inhibitory...

journal_title：Journal of Asian natural products research

authors： Jiang JS,Li FS,Feng ZM,Yang YN,Zhang PC

更新日期：2020-01-01 00:00:00

abstract：:A profiling analysis of the total isoflavone extract of the root of Pueraria lobata (Wild.) Ohwi was performed using HPLC coupled with ESI-ion trap mass spectrometry. A total of seven isoflavones were identified according to their retention times, UV, MS data, and comparing with the literature data. Among them, two pr...

journal_title：Journal of Asian natural products research

authors： Zhang HJ,Yang XP,Wang KW

更新日期：2010-04-01 00:00:00

abstract：:Verticilliside (1), a new flavone C-glucoside, has been isolated from the ethyl acetate soluble fraction of Enicostemma verticillatum and its structure is assigned on the basis of the spectroscopic data. 5,7,4'-Trihydroxyflavone 8-C-beta-D-glucopyranoside (2) and isoorientin 3'-O-methyl ether (3) have also been isolat...

journal_title：Journal of Asian natural products research

authors： Jahan E,Perveen S,Malik A

更新日期：2009-01-01 00:00:00

abstract：:A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, H...

journal_title：Journal of Asian natural products research

authors： Wu XL,Wu YL,Li HG,Liu HT,Fu XY,Cui RQ,Wang JH,Liu C,Chen J

更新日期：2014-01-01 00:00:00

abstract：:From the EtOH extract of the flowers of Camellia nitidissima Chi, a new acylated flavonoid glycoside, quercetin 7-O-(6"-O-E-caffeoyl)-β-D-glucopyranoside (1), has been isolated, together with three known flavonoids: quercetin (2), quercetin 3-O-β-D-glucopyranoside (3), and quercetin 7-O-β-D-glucopyranoside (4). Their ...

journal_title：Journal of Asian natural products research

authors： Peng X,Yu DY,Feng BM,Wang YQ,Shi LY

更新日期：2012-01-01 00:00:00