Abstract:
:Liver is the largest metabolic organ for a wide range of endogenous and exogenous compounds and plays a crucial part in the pharmacokinetics and pharmacodynamics through various metabolic reactions. This review provides a progressive description of hepatic metabolism of herbal drugs with respect to metabolic types and investigational methods. In addition, the problems encountered during the research process are discussed.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Peng YS,Liu B,Wang RF,Zhao QT,Xu W,Yang XWdoi
10.1080/10286020.2014.960856subject
Has Abstractpub_date
2015-01-01 00:00:00pages
89-106issue
1eissn
1028-6020issn
1477-2213journal_volume
17pub_type
杂志文章,评审abstract::Two new lignans named neourticol A (1) and neourticol B (2), together with seven known compounds (3-9), were isolated from Urticae Fissae Herba, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1 and 2 possessed the potent anti-complement and anti-inflammatory activities. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2018.1457652
更新日期:2019-06-01 00:00:00
abstract::A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels-Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1) and kuwanon R (2) by means of spectroscopic methods. Both compounds st...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2012.670221
更新日期:2012-01-01 00:00:00
abstract::Three new flavonol glycosides, kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside (1), kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (2), and kaempferol-3-O-(6-trans-p-coumaroyl)-beta-D-glucopyranosyl-(1 --> 2)-...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/1028602042000325627
更新日期:2006-01-01 00:00:00
abstract::A new bioactive flavone glycoside 1 [mp 252-254 degrees C, C28H32O16, [M]+ 624 (EIMS)] was isolated from the acetone soluble fraction of the defatted seeds of Cassia fistula (Linn.). It was characterized as a new bioactive flavone glycoside 5,3',4'-tri-hydroxy-6-methoxy-7-O-alpha-L-rhamnopyranosyl-(1 --> 2)-O-beta-D-g...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/1028602031000080478
更新日期:2003-03-01 00:00:00
abstract::A new diterpenoid, dehydrovibsanin G (1), a new lignan, (+)-9'-O-senecioyllariciresinol (2), and six known compounds (3-8) were isolated from the branches and leaves of Viburnum odoratissimum var. odoratissimum. The structures of these compounds were elucidated by analysis of spectroscopic data. Both new compounds sho...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1041934
更新日期:2015-05-01 00:00:00
abstract::(-)-Incrustoporin (1) has been synthesized using aldol condensation of ethyl p-tolyl-acetate (2) and (2R)-benzoyloxy-butanal (3), followed by acid-catalyzed deprotection of the benzoyl group, lactone ring-closure, and elimination of the beta-OH in a one-pot manner. The aldehyde 3 was prepared from the commercially ava...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286029908039863
更新日期:1999-01-01 00:00:00
abstract::A new sesquiterpene cacaroborin (1) was isolated from the roots of Cacalia roborowskii, together with three known ones, cinalbicol (2), isopetasin (3), and 3alpha-angeloyloxylactone (4). The structure of compound 1 was elucidated as 1beta,10alpha-dihydroxy-8alpha-methoxyeremophil-7(11)-en-8beta,12-olide on the basis o...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020903264093
更新日期:2009-11-01 00:00:00
abstract::A new furanocoumarin named lucidafuranocoumarin A (7) together with 13 known coumarins (1-6, 8-14) and four known alkaloids (15-18) was isolated from the roots of Feroniella lucida. Their structures were elucidated on the basis of spectroscopic analysis. Some of the isolates were evaluated for their biological activit...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.572878
更新日期:2011-06-01 00:00:00
abstract::A novel alkaloid, hupcrispatine (1), has been isolated from the unique Chinese species Huperzia crispate Ching. The structure of hupcrispatine has been elucidated as 9-amino-6-methyl-3-quinolone on the basis of spectral evidence. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020802181448
更新日期:2008-09-01 00:00:00
abstract::Two new selaginellin derivatives, selaginellins K (1) and L (2), were isolated from Selaginella tamariscina (Beauv.) Spring and characterized as 2-formyl-4,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene and 4,4'-dihydroxy-2-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene on the basis of their spectroscopic data including...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.558840
更新日期:2011-04-01 00:00:00
abstract::Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical-chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excel...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020802240376
更新日期:2008-09-01 00:00:00
abstract::Five new phenolic glycosides, 2-hydroxy-(2'E)-prenyl benzoate-2,4'-di-O-β-D-glucopyranoside (1), 2-hydroxy-(2'E)-prenyl benzoate-2-O-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranoside (2), 4-methylphenol-1-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (3), 4-methylphenol-1-O-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyr...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.922552
更新日期:2014-01-01 00:00:00
abstract::A new diimide derivative, named (-)-byssochlamic acid bisdiimide (1), was isolated from the mixed broth of two mangrove fungi (strain no. K38 and E33) from the South China sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) and semi-synthe...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2010.497757
更新日期:2010-09-01 00:00:00
abstract::A new acylated C-glycosylflavone (1) was isolated from Trollius ledebouri Reichb together with two known C-glycosyflavones (2, 3). The structures were elucidated by spectroscopic methods, including HRMS, IR, 1H and 13C NMR and 2D experiments (COSY, HMQC and HMBC). The anti-inflammatory activities of 1-3 were tested on...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020500176922
更新日期:2006-09-01 00:00:00
abstract::A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2017.1383397
更新日期:2018-08-01 00:00:00
abstract::A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamine and 10 novel-substituted 3-benzylmercapto-1,2,4-triazol derivatives were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS, and X-ray. Most substituted 3-benz...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2020.1754400
更新日期:2020-05-07 00:00:00
abstract::Four new furostanol glycosides were isolated from the flowers of Hosta plantaginea (Lam.) Aschers. On the basis of spectroscopic methods including 1D and 2D NMR experiments, their structures were elucidated as 26-O-β-d-glucopyranosyl-(25R)-22-O-methyl-5α-furostan-2α,3β,22ξ,26-tetrol 3-O-α-l-rhamnopyranosyl-(1 → 4)-O-β...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.998652
更新日期:2015-01-01 00:00:00
abstract::Three new alkylated benzoquinones, 2-hydroxy-5-ethoxy-3-nonyl-1,4-benzoquinone (1), 5-O-butyl-embelin (2), and 2,5-dihydroxy-6-methyl-3-pentadecyl-1,4-benzoquinone (3), together with seven known analogues (4-10), were isolated from the stems and twigs of mangrove plant, Aegiceras corniculatum. Their structural elucida...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2018.1540604
更新日期:2020-02-01 00:00:00
abstract::A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, H...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.885506
更新日期:2014-01-01 00:00:00
abstract::A new coumarin glucoside, 8-hydroxy-5-O-beta-D-glucosylpsoralen, along with 17 known coumarins and one steroid, was isolated from the roots of Heracleum rapula Franch. Four coumarin glucosides, including the new one, were obtained from the water-soluble fraction. The other coumarins isolated from the ethyl acetate-fra...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020290019677
更新日期:2002-03-01 00:00:00
abstract::Two new cycloartane glycosides were isolated from the aerial parts of Thalictrum fortunei (Ranunculaceae). The chemical structures of these compounds were elucidated as 3-O-β-D-glucopyranosyl (1 → 4)-β-d-fucopyranosyl-(22S,24Z)-cycloart-24-en-3β,22,26,30-tetraol 26-O-β-D-glucopyranoside and 3-O-β-D-glucopyranosyl (1 →...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.653684
更新日期:2012-01-01 00:00:00
abstract::Six new sesquiterpenes, 10-hydroxy-epiaplysin (1), 10-hydroxy-aplysin (2), 10-hydroxy-debromoepiaplysin (3), aplysin-9-ene (4), epiaplysinol (5) and debromoepiaplysinol (6), together with 13 known compounds (7-19), have been isolated from the red alga Laurencia tristicha. The structures of 1-6 were determined by spect...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020601103338
更新日期:2007-09-01 00:00:00
abstract::Two new acetylated flavan glycosides (2S,4R)-4,5,7-trihydroxy-4'-methoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (1) and (2S,4R)-5,7-dihydroxy-4,4'-dimethoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (2) were isolated from the rhizomes of Abacopteris ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2010.525744
更新日期:2010-12-01 00:00:00
abstract::A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.841675
更新日期:2014-01-01 00:00:00
abstract::Two new monoterpenoid glycosides, α-(E)-acaridiol 8-O-β-d-glucopyranoside (1) and α-(E)-acaridiol 9-O-β-d-glucopyranoside (2), as well as a new thiophen, 2-acetyl-3-hydroxy-5-(prop-1-ynyl)thiophen 3-O-β-d-glucopyranoside (3), were isolated from the roots of Eupatorium chinense. Their structures were determined on the ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.598149
更新日期:2011-09-01 00:00:00
abstract::Fasciospyrinadine (1), a novel sesquiterpene pyridine alkaloid with a previously unreported skeleton featuring a monocyclicfarnesane moiety attached to a 3-methylenepyridine residue, was isolated from the sponge Fasciospongia sp. from Weizhou Island, Guangxi Autonomous Region. The structure and the relative stereochem...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2012.751098
更新日期:2013-01-01 00:00:00
abstract::One novel ursolic acid derivative sabiracin 1 (11,25-epoxy-3β-hydroxy-urs-12-en-28-oic acid) was isolated from the leaves of Carissa carandas, together with five known compounds para hydroxy benzaldehyde (2), ursolic acid (3), carissin (4), 22α-hydroxyursolic acid (5) and β-sitosterol-3-O-β-D-glucopyranoside (6). Comp...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2020.1791098
更新日期:2020-07-10 00:00:00
abstract::Activity-guided fractionation of Neosinocalamus affinis leaves led to obtain two new flavonoids, 4'-O-((7″R,8″S)-8″-guaiacylglyceryl)-pleioside B (9) and apigenin 6-C-β-d-fucopyranosyl-7-O-β-d-glucopyranoside (10) along with eight known compounds. Their structures were elucidated on the basis of spectroscopic data (UV...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.981164
更新日期:2015-01-01 00:00:00
abstract::Microbial transformation of oleanolic acid (1) was carried out. Six transformed products (2-7) from 1 by Alternaria longipes and three transformed products (8-10) from 1 by Penicillium adametzi were isolated. Their structures were elucidated as 2α,3α,19α-trihydroxy-ursolic acid-28-O-β-d-glucopyranoside (2), 2α,3β,19α-...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2010.547028
更新日期:2011-02-01 00:00:00
abstract::Eight tetranortriterpenoids (1-8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1β-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR an...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.938060
更新日期:2014-01-01 00:00:00