Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi).

Abstract:

:Chemical studies on the roots of Fraxinus rhynchophylla led to the isolation of fraxisecoside (1), a novel coumarin-secoiridoid hybrid glycoside, namely, fraxetin-8-O-[11'-methyl-oleosidyl-(7'-->6'')]-beta-D-glucopyranoside and 14 known compounds. Their structures were elucidated based on chemical evidence and spectroscopic analysis, including extensive 2D NMR methods. Compound 2 was first isolated as a pure compound. Compound 1 exhibited moderate PTP1B inhibition activity. Compounds 1 and 2 showed inhibition activity against B- and T-cell proliferation, without cytotoxicity.

journal_name

J Asian Nat Prod Res

authors

Xiao K,Song QH,Zhang SW,Xuan LJ

doi

10.1080/10286020701394514

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

205-10

issue

1-2

eissn

1028-6020

issn

1477-2213

pii

790390854

journal_volume

10

pub_type

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