Coumarins from Daphne feddei and their potential anti-inflammatory activities.

Abstract:

:Chemical examination of the methanolic extract from the stem bark of Daphne feddei led to the isolation of three new dicoumarin glucosides (1-3), and eight known coumarins, dicoumarins and dicoumarin glucosides. Their structures were elucidated by extensive analysis of spectral data and comparison with the literature values. All compounds were tested for inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 macrophages, and compounds 4 and 5 showed potent inhibitory activity with IC₅₀ values of 0.161 and 0.127 μM, respectively.

journal_name

J Asian Nat Prod Res

authors

Liang S,Feng Y,Tian JM,Lu M,Xiong Z,Zhang WD

doi

10.1080/10286020.2011.621892

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1074-80

issue

12

eissn

1028-6020

issn

1477-2213

journal_volume

13

pub_type

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