Abstract:
:Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined with chemical methods and electronic circular dichroism spectra calculations. In the preliminary assays, compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6-33.3 μM. Compound 1 also exhibited inhibitory effect against nitric oxide (NO) production in microglial cell BV2 with an inhibition ratio of 93.0% at 10 μM.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Liu YF,Chen MH,Lin S,Li YH,Zhang D,Jiang JD,Shi JGdoi
10.1080/10286020.2015.1117452subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1-12issue
1eissn
1028-6020issn
1477-2213journal_volume
18pub_type
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