Indole alkaloid glucosides from the roots of Isatis indigotica.

Abstract:

:Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined with chemical methods and electronic circular dichroism spectra calculations. In the preliminary assays, compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6-33.3 μM. Compound 1 also exhibited inhibitory effect against nitric oxide (NO) production in microglial cell BV2 with an inhibition ratio of 93.0% at 10 μM.

journal_name

J Asian Nat Prod Res

authors

Liu YF,Chen MH,Lin S,Li YH,Zhang D,Jiang JD,Shi JG

doi

10.1080/10286020.2015.1117452

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

1-12

issue

1

eissn

1028-6020

issn

1477-2213

journal_volume

18

pub_type

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