Abstract:
:Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined with chemical methods and electronic circular dichroism spectra calculations. In the preliminary assays, compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6-33.3 μM. Compound 1 also exhibited inhibitory effect against nitric oxide (NO) production in microglial cell BV2 with an inhibition ratio of 93.0% at 10 μM.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Liu YF,Chen MH,Lin S,Li YH,Zhang D,Jiang JD,Shi JGdoi
10.1080/10286020.2015.1117452subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1-12issue
1eissn
1028-6020issn
1477-2213journal_volume
18pub_type
杂志文章abstract::Our current marine natural product program investigated the second metabolites of an actinomycete Streptomyces cavourensis YY01-17 originating from the Antarctic ecological niche to discover potential antitumor chemical entities. Two new compounds, along with a known compound, were isolated from the ethyl acetate extr...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2012.762764
更新日期:2013-01-01 00:00:00
abstract::Chemical investigation on the cultures of Phellinus tuberculosus and Laetiporus sulphureus lead to the isolation of two new illudin-type sesquiterpenoids (phellinuin J and sulphureuine A). Their structures were elucidated by 1D, 2D NMR and MS spectroscopic data. These compounds were purposely evaluated for their cytot...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1040774
更新日期:2015-01-01 00:00:00
abstract::A new furanocoumarin named lucidafuranocoumarin A (7) together with 13 known coumarins (1-6, 8-14) and four known alkaloids (15-18) was isolated from the roots of Feroniella lucida. Their structures were elucidated on the basis of spectroscopic analysis. Some of the isolates were evaluated for their biological activit...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.572878
更新日期:2011-06-01 00:00:00
abstract::Two new monoterpenoid glycosides, α-(E)-acaridiol 8-O-β-d-glucopyranoside (1) and α-(E)-acaridiol 9-O-β-d-glucopyranoside (2), as well as a new thiophen, 2-acetyl-3-hydroxy-5-(prop-1-ynyl)thiophen 3-O-β-d-glucopyranoside (3), were isolated from the roots of Eupatorium chinense. Their structures were determined on the ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.598149
更新日期:2011-09-01 00:00:00
abstract::Two new phenolic glycosides were isolated from the seeds of Cucurbita moschata. Their structures were elucidated as (2-hydroxy)phenylcarbinyl 5-O-benzoyl-beta-D-apiofuranosyl(1-->2)-beta-D-glucopyranoside (1) and 4-beta-D-(glucopyranosyl hydroxymethyl)phenyl 5-O-benzoyl-beta-D-apiofuranosyl(1-->2)-beta-D-glucopyranosi...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020902942376
更新日期:2009-07-01 00:00:00
abstract::Three new sesquiterpenoids (1-3), along with four known compounds (4-7), were isolated from cultures of the fungus Conocybe siliginea. The structures of new compounds were elucidated using spectroscopic methods. The known compounds were identified by comparing their spectroscopic data with those reported in the litera...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.939072
更新日期:2015-01-01 00:00:00
abstract::Two new steroidal saponins were isolated from the fruits of Tribulus terrestris L. Their structures were elucidated by spectroscopic and chemical analysis as (23S,24R,25R)-5alpha-spirostane-3beta,23,24-triol-3-O-{alpha-L-rhamnopyranosyl-(1 --> 2)-[beta-D-glucopyranosyl-(1 --> 4)]-beta-D-galactopyranoside} (1) and (23S...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020903405449
更新日期:2010-01-01 00:00:00
abstract::Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most s...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020801948334
更新日期:2008-05-01 00:00:00
abstract::Two new selaginellin derivatives, selaginellins K (1) and L (2), were isolated from Selaginella tamariscina (Beauv.) Spring and characterized as 2-formyl-4,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene and 4,4'-dihydroxy-2-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene on the basis of their spectroscopic data including...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.558840
更新日期:2011-04-01 00:00:00
abstract::The Amaranthaceae plant, Pfaffia glomerata, which is so-called as Brazil ginseng, is widely distributed in South American countries. Three new noroleanane-type triterpenes and four known oleanane-type triterpenes were isolated from the roots of P. glomerata. Their structures were determined by spectroscopic methods in...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2017.1343820
更新日期:2018-05-01 00:00:00
abstract::Two new guaianolides artemanomalides A and B were isolated from the aerial parts of Artemisia anomala S. Moore. Their structures were characterized as 2-oxo-5α, 10α-dihydroxy-guaia-3-en-1α, 6β, 7α, 11β H-12, 6-olide (1) and 8α-acetoxy-2-oxo-5α, 10α-dihydroxy-guaia-3, 11(13)-dien-1α, 6β, 7αH-12, 6-olide (2) on the basi...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.634802
更新日期:2012-01-01 00:00:00
abstract::A palmatine derivative, named 11-hydroxypalmatine (4), has been isolated from the tubers of Stephania glabra, together with three known alkaloids, palmatine (1), dehydrocorydalmine (2), and stepharanine (3). The structures of the compounds were elucidated by means of spectroscopic analysis including 2D NMR experiments...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020903117325
更新日期:2010-02-01 00:00:00
abstract::Resveratrol (3,4',5-trihydroxy-trans-silbene), a natural phytoalexin found in grapes and other food products, has promising anti-inflammatory and anticancer effects. To observe the modulation of interleukin-8 (IL-8) production in human monocytic cells by resveratrol and explore its mechanism at the gene transcription ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/1028602031000066852
更新日期:2003-06-01 00:00:00
abstract::Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual et...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.898634
更新日期:2014-01-01 00:00:00
abstract::One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2021.1873298
更新日期:2021-01-18 00:00:00
abstract::The rhizome of Acorus tatarinowii is a well-known traditional Chinese medicine. Our extensive investigation on this plant material afforded two new compounds, including a cadinane-type sesquiterpenoid and a pyrazine derivative, along with seven known compounds. The structures of the new compounds, tatarinowin B and ta...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2010.490522
更新日期:2010-06-01 00:00:00
abstract::Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These co...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1047354
更新日期:2015-05-01 00:00:00
abstract::Chromatographic separation of the ethyl acetate soluble part of the methanolic extract from Seriphidium stenocephalum yielded three new compounds: stenocepflavone (1), stenocepflavan (2), and stenocephol (3), together with cirsimaritin (4), 5,7,5'-trihydroxy-3',4',6-trimethoxyflavone (5), 5,6,7,5'-tetrahydroxy-4'-meth...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.763226
更新日期:2013-01-01 00:00:00
abstract::Mangrove endophytic fungi were proved to be a prolific resources for bioactive secondary metabolites. Two new polyketides, pestalotiopin B (1) and pestalotiopyrone N (2) were obtained from the ethyl acetate extracts of the rice solid cultures of the mangrove endophytic fungus Pestalotiopsis sp. HQD-6. The structures o...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2021.1877674
更新日期:2021-01-29 00:00:00
abstract::3,7-Dimethyl-7-hydroxy-2-octen-1,6-olide and 3,7-dimethyl-2,6-octadien-1,6-olide, the natural bioactive compounds isolated from the fruit of Litsea cubeba and the liverwort Plagiochila rutilans, were totally synthesized using easily available cis-geraniol as raw material in short, convenient, and low-cost, five-step r...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.803474
更新日期:2013-01-01 00:00:00
abstract::A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.841675
更新日期:2014-01-01 00:00:00
abstract::(-)-Incrustoporin (1) has been synthesized using aldol condensation of ethyl p-tolyl-acetate (2) and (2R)-benzoyloxy-butanal (3), followed by acid-catalyzed deprotection of the benzoyl group, lactone ring-closure, and elimination of the beta-OH in a one-pot manner. The aldehyde 3 was prepared from the commercially ava...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286029908039863
更新日期:1999-01-01 00:00:00
abstract::Three new acetylated anthraquinone glycosides (1-3) were isolated from the seed of Cassia obtusifolia, together with one parent anthraquinone glycoside (1a). Their structures were determined on the basis of spectroscopic methods and physicochemical properties as obtusifoline-2-O-β-d-2, 6-di-O-acetylglucopyranoside (1)...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.570264
更新日期:2011-06-01 00:00:00
abstract::A new minor sesquiterpene lactone glucoside, ixerin ZA (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6'-(p-metheoxyphenylacetyl)]-beta-glucopyranoside on the basis of sp...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020500532140
更新日期:2006-09-01 00:00:00
abstract::Investigation of the constituents from the stem barks of Garcinia multiflora has yielded two new compounds, multiflorabiphenyl A (1) and 24-p-E-coumaroyl-tetracosanyl (E)-ferulate (2), along with 10 known compounds, friedelin (3), friedelan-3β-ol (4), α,β-amyrin (5), rheediachromenoxanthone (6), 1,7-dihydroxyxanthone ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.819854
更新日期:2013-11-01 00:00:00
abstract::An investigation of CH(2)Cl(2) and EtOH extracts of Trifolium resupinatum L. var. microcephalum Zoh. has led to the isolation of two new compounds characterized as 4,15-dimethyl-2-(1,2-dihydroxyethyl)-hexadecene (1) and 1-undecene-1-O-beta-2',3',4',6'-tetraacetyl glucopyranoside (2a). Their structures were established...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020802278038
更新日期:2008-11-01 00:00:00
abstract::Three new compounds, namely massonside C (1), massonianoside F (2), and 3, 8-dimethyl- herbacetin-7-O-β-D-glucopyranoside (3), together with five known compounds (4-8), were isolated from the fresh needles of Pinus massoniana. Their structures were established by 1D, 2D NMR, HRMS and comparison with the literature dat...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2019.1642331
更新日期:2020-08-01 00:00:00
abstract::Two new furostanol glycosides, ophiopogonins H (1) and I (2), were isolated from the fibrous root of Ophiopogon japonicus. The structures of 1 and 2 were established as (25R)-26-[(O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl)]-22α-hydroxyfurost-5-ene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and (25R)-26-[(...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2010.495332
更新日期:2010-09-01 00:00:00
abstract::Two new lignan glycosides forsythiayanoside A (1) and forsythiayanoside B (2), one new stereoisomer of lignan glycoside (+)-8-hydroxyepipinoresinol-4-O-β-D-glucopyranoside (3), together with seven known compounds (4-10), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. Compounds 4 and 10 were isolate...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.917631
更新日期:2014-01-01 00:00:00
abstract::Phytochemical analysis of the MeOH extract of the fruiting bodies of Stropharia aeruginosa resulted in the isolation of three lanostane triterpenoids, aeruginosols A, B and C. The structures of the new compounds were determined by spectroscopic analysis. The biological activities of aeruginosols A, B and C were examin...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020600882254
更新日期:2007-09-01 00:00:00