Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L.

abstract：:Four types of piscidinol A derivatives were synthesized and evaluated their ability to inhibit HIV-1 protease to understand their structure-activity relationships. Of these tirucallane-type triterpene derivatives, an A-seco derivative (1b) moderately inhibited human immunodeficiency virus (HIV) protease (IC50 38.2 μM)...

journal_title：Journal of Asian natural products research

authors： Wei Y,Ma CM,Jiang TB,Du J,Zhou X,Liu GQ,Hattori M

更新日期：2015-01-01 00:00:00

abstract：:A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and five known flavonoid glycosides (2-6) were isolated from the leaves and stems of Clausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and NMR spectroscopic d...

journal_title：Journal of Asian natural products research

authors： Cao NK,Zhu SS,Chen YM,Ma XL,Zhao MB,Li J,Tu PF,Jiang Y

更新日期：2020-08-30 00:00:00

abstract：:Three new xanthone glycosides, securixanside A (1), securixanside B (2), and securixanside C (3) were isolated from the stems of Securidaca inappendiculata. These compounds were characterized by spectrometric and chemical methods, including FABMS and one- and two-dimensional NMR experiments. ...

journal_title：Journal of Asian natural products research

authors： Yang XD,An N,Xu LZ,Yang SL

更新日期：2002-06-01 00:00:00

abstract：:Anemarchalconyn (1) and anemarcoumarin A (2), the natural bioactive compounds isolated from the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae), were first totally synthesized using easily available materials in short, convenient routes with overall yields of 32 and 48%. ...

journal_title：Journal of Asian natural products research

authors： Zhang JX,Li ZY,Wang YC,Ma WB,Hou M,Cao SH,Tang KH,Dong HB

更新日期：2017-09-01 00:00:00

abstract：:One new flavone, 5,7-dihydroxy-8,2',3',6'-tetramethoxyflavone (1), and one new flavonol, 5,7,6'-trihydroxy-2'-methoxyflavonol (2), were isolated from the roots of Scutellaria baicalensis, and their structures were elucidated on the basis of extensive spectroscopic evidences, especially 1D and 2D NMR and HR-ESI-MS expe...

journal_title：Journal of Asian natural products research

authors： Long HL,Xu GY,Deng AJ,Li ZH,Ma L,Lu Y,Zhang ZH,Wu F,Qin HL

更新日期：2015-01-01 00:00:00

abstract：:Two new C21 steroidal glycosides were isolated from Cynanchum wallichii Wight. Their structures were elucidated as caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-digitoxopyranoside (1) and caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-ole...

journal_title：Journal of Asian natural products research

authors： Wang D,Pan WH,Bao YR,Yang XX,Meng XS

更新日期：2014-01-01 00:00:00

abstract：:A new diimide derivative, named (-)-byssochlamic acid bisdiimide (1), was isolated from the mixed broth of two mangrove fungi (strain no. K38 and E33) from the South China sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) and semi-synthe...

journal_title：Journal of Asian natural products research

authors： Li CY,Ding WJ,Shao CL,She ZG,Lin YC

更新日期：2010-09-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the major causative agent of hand foot and mouth disease. And EV71 causes epidemics worldwide, particularly in the Asia-Pacific region. Unfortunately, currently there is no approved vaccine or antiviral drug for EV71-induced disease prevention and therapy. In screening for anti-EV71 candidates...

journal_title：Journal of Asian natural products research

authors： Wang HQ,Meng S,Li ZR,Peng ZG,Han YX,Guo SS,Cui XL,Li YH,Jiang JD

更新日期：2013-01-01 00:00:00

abstract：:Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and nodakenetin, were investigated. The irritant potential was explored by open mou...

journal_title：Journal of Asian natural products research

authors： Saeed MA,Sabir AW

更新日期：2008-01-01 00:00:00

abstract：:A new ester, 2-(4'-hydroxyphenyl)ethyl dotriacontanoate (1), and a new inseparable mixture of octacosan-1,28-dioldiferulate and triacontan-1,30-dioldiferulate (2) were isolated from the stem barks of Stereospermum acuminatissimum, along with 24 known compounds including 4 triterpenoids, 11 anthraquinones, 2 lignans, 3...

journal_title：Journal of Asian natural products research

authors： Sob SV,Wabo HK,Tang CP,Tane P,Ngadjui BT,Ye Y

更新日期：2011-12-01 00:00:00

abstract：:Two new indole-diterpenoids named penijanthine B and penitrem H were isolated from the metabolites of the fungus Penicilliumcrustosum YN-HT-15, which was isolated from the red soil of Yunnan Province of China. The structures were determined on spectroscopic analyses and CD spectra. ...

journal_title：Journal of Asian natural products research

authors： Su SS,Song AH,Chen G,Wang HF,Li ZQ,Pei YH

更新日期：2014-01-01 00:00:00

abstract：:Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that ...

journal_title：Journal of Asian natural products research

authors： Chong YM,Kaur G,Tan ML

更新日期：2019-08-01 00:00:00

abstract：:Six thiophenes were isolated and purified from ethanol extract of the roots of Echinops latifolius Tausch. Their structures were identified on the basis of spectral data. Among them, 5-(3-hydroxmethyl-3-isovaleroyloxyprop-1-ynyl)-2,2'-bithiophene (6) is a new compound, and 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2'...

journal_title：Journal of Asian natural products research

authors： Wang Y,Li X,Meng DL,Li ZL,Zhang P,Xu J

更新日期：2006-10-01 00:00:00

abstract：:A profiling analysis of the total isoflavone extract of the root of Pueraria lobata (Wild.) Ohwi was performed using HPLC coupled with ESI-ion trap mass spectrometry. A total of seven isoflavones were identified according to their retention times, UV, MS data, and comparing with the literature data. Among them, two pr...

journal_title：Journal of Asian natural products research

authors： Zhang HJ,Yang XP,Wang KW

更新日期：2010-04-01 00:00:00

abstract：:Two new homoisoflavonoids, ( ± )-5,7-dihydroxy-8-methyl-3-(2',4'-dihydroxybenzyl) chroman-4-one (1) and ( ± )-5,7-dihydroxy-6,8-dimethyl-3-(2',4'-dihydroxybenzyl) chroman-4-one (2), along with two known homoisoflavonoids, 5,7-dihydroxy-6-methyl-3-(2',4'-dihydroxybenzyl)chroman-4-one (3) and disporopsin (4), were isola...

journal_title：Journal of Asian natural products research

authors： Li LM,Yuan QP,Chen G

更新日期：2014-01-01 00:00:00

abstract：:A new triterpenoid, 11α,12α-epoxy-3β-hydroxy-24-nor-olean-4(23)-en-28,13β-olide (1), and a new glycoside, benzyl 2-O-β-d-apiofuranosyl-(1 → 2)-β-d-glucopyranosyl benzoate (2), together with eight known triterpenoids (3-10), were isolated from Pilea cavaleriei subsp. cavaleriei. Their structures were established on the...

journal_title：Journal of Asian natural products research

authors： Ren HC,Qin RD,Wang Q,Cheng W,Zhang QY,Liang H

更新日期：2012-01-01 00:00:00

abstract：:Four new minor taxanes (1-4) have been isolated from Ts-19 cell cultures of Taxus chinensis together with five known taxanes (5-9) by silica gel chromatography combined with semi-preparative HPLC chromatography. On the basis of the analyses of the chemical and spectroscopic (IR, MS, 1D, and 2D NMR) data, the structure...

journal_title：Journal of Asian natural products research

authors： Xie D,Jia HT,Zhang Y,Zou JH,Yin DL,Chen XG,Yan YN,Dai JG

更新日期：2009-06-01 00:00:00

abstract：:Three new alkylated benzoquinones, 2-hydroxy-5-ethoxy-3-nonyl-1,4-benzoquinone (1), 5-O-butyl-embelin (2), and 2,5-dihydroxy-6-methyl-3-pentadecyl-1,4-benzoquinone (3), together with seven known analogues (4-10), were isolated from the stems and twigs of mangrove plant, Aegiceras corniculatum. Their structural elucida...

journal_title：Journal of Asian natural products research

authors： Li Y,Dong C,Xu MJ,Lin WH

更新日期：2020-02-01 00:00:00

abstract：:During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50 = 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell line...

journal_title：Journal of Asian natural products research

authors： Guan YY,Li SZ,Lei PS

更新日期：2017-05-01 00:00:00

abstract：:A chemical investigation of the endemic relict shrub Tetraena mongolica led to the isolation of four new triterpenes: 11α,12α:13β,28-diepoxyoleanane-3β-yl trans-caffeate (1), 3β-hydroxy-11α,12α-epoxyoleanane-28-al (2), olean-11-en-28-al-3β-yl trans-caffeate (3), and 28-acetoxy-olean-12-en-3β-yl trans-caffeate (4). The...

journal_title：Journal of Asian natural products research

authors： Tang SA,Ding LL,Zhai HY,Qin N,Duan HQ

更新日期：2012-01-01 00:00:00

abstract：:Manuifolin Q (1), an unusual 4-aryl-substituted isoflavan, was isolated from the roots of Maackia tenuifolia. Its absolute configuration was determined as (3R,4R)-3,4-trans-7,2'-dihydroxy-4'-methoxy-4-[(2,4-dihydroxy-5-(1,1-dimethyl-2-propenyl)]-phenyl-isoflavan, on the basis of spectroscopic analysis. ...

journal_title：Journal of Asian natural products research

authors： Zeng JF,Tan CH,Zhu DY

更新日期：2004-03-01 00:00:00

abstract：:A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3β,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark of Aglaia angustifolia Miq. The Chemical structure of the new compou...

journal_title：Journal of Asian natural products research

authors： Hutagaol RP,Harneti D,Safari A,Hidayat AT,Supratman U,Awang K,Shiono Y

更新日期：2020-06-13 00:00:00

abstract：:(+)-Lariciresinol 3a-acetate [(+)-(3S)-acetyloxymethyl-(2S)-(4-hydroxy-3-methoxyphenyl)-(4R)-[(4-hydroxy-3-methoxyphenyl)methyl]tetrahydrofuran] (1), a metabolite of A. elaeagnoidea was synthesized starting from (-)-lariciresinol (2) in three steps with an overall yield of 66%. ...

journal_title：Journal of Asian natural products research

authors： Rajasekhar D,Subbaraju GV

更新日期：2000-01-01 00:00:00

abstract：:Three new compounds (1-3), named dasycarine G (1), dasycarether (2), and dasycarester (3), along with seven known compounds (4-10) obtained from the genus Dictamnus for the first time, were isolated from the root bark of Dictamnus dasycarpus. Their structures were elucidated on the basis of spectroscopic data (UV, IR,...

journal_title：Journal of Asian natural products research

authors： Gao P,Wang L,Zhao L,Zhang C,Zeng KW,Zhao MB,Zhang QY,Jiang Y,Tu PF,Guo XY

更新日期：2020-08-01 00:00:00

abstract：:Two new diterpenes and ent-15alpha-hydroxykaur-16-en-19-oic acid 11,12-acetonide (3), together with 23 known compounds were isolated from the dried aerial parts of Nouelia insignis Franch. The structures of new compounds were determined to be ent-14beta,15alpha-dihydroxykaur-16-en-19-oic acid (1), ent-14beta-hydroxy-1...

journal_title：Journal of Asian natural products research

authors： Hu XY,Luo YG,Chen XZ,Zhou L,Zhang GL

更新日期：2008-01-01 00:00:00

abstract：:Three new C(19)-diterpenoid alkaloids, umbrosumines A-C (1-3), and 11 known compounds (4-14) were isolated from the roots of Delphinium umbrosum. Their structures were elucidated on the basis of the spectroscopic data interpretation. ...

journal_title：Journal of Asian natural products research

authors： Chen FZ,Chen QH,Wang FP

更新日期：2010-06-01 00:00:00

abstract：:Chromatographic separation of the ethyl acetate soluble part of the methanolic extract from Seriphidium stenocephalum yielded three new compounds: stenocepflavone (1), stenocepflavan (2), and stenocephol (3), together with cirsimaritin (4), 5,7,5'-trihydroxy-3',4',6-trimethoxyflavone (5), 5,6,7,5'-tetrahydroxy-4'-meth...

journal_title：Journal of Asian natural products research

authors： Shafiq N,Riaz N,Ahmed S,Ashraf M,Ejaz SA,Ahmed I,Saleem M,Touseef MI,Tareen RB,Jabbar A

更新日期：2013-01-01 00:00:00

abstract：:Ophiopogon japonicus polysaccharide (FOJ-5) from Radix ophiopogonis has shown anti-myocardial ischemic action in vitro and in vivo in our previous studies. In order to clarify the influence of chemical modifications on the action, a series of sulfated FOJ-5 (FOJ-5-S) with different substitution degrees were prepared a...

journal_title：Journal of Asian natural products research

authors： Zheng Q,Feng Y,Xu DS,Lin X,Chen YZ

更新日期：2009-01-01 00:00:00

abstract：:A phytochemical study on the seeds of Cassia obtusifolia was carried out, which finally led to obtain two naphthalenes (1 and 2), two naphthopyrans (3 and 4) and twelve anthraquinones (5-16). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence. A...

journal_title：Journal of Asian natural products research

authors： Pang X,Li NN,Yu HS,Kang LP,Yu HY,Song XB,Fan GW,Han LF

更新日期：2019-10-01 00:00:00

abstract：:A new coumarin glucoside, 8-hydroxy-5-O-beta-D-glucosylpsoralen, along with 17 known coumarins and one steroid, was isolated from the roots of Heracleum rapula Franch. Four coumarin glucosides, including the new one, were obtained from the water-soluble fraction. The other coumarins isolated from the ethyl acetate-fra...

journal_title：Journal of Asian natural products research

authors： Niu XM,Li SH,Jiang B,Zhao QS,Sun HD

更新日期：2002-03-01 00:00:00