New alkylated benzoquinones from mangrove plant Aegiceras corniculatum with anticancer activity.

Abstract:

:Three new alkylated benzoquinones, 2-hydroxy-5-ethoxy-3-nonyl-1,4-benzoquinone (1), 5-O-butyl-embelin (2), and 2,5-dihydroxy-6-methyl-3-pentadecyl-1,4-benzoquinone (3), together with seven known analogues (4-10), were isolated from the stems and twigs of mangrove plant, Aegiceras corniculatum. Their structural elucidation was achieved by spectroscopic methods, chemical exchanging experiments, and semisynthesis method. The cytotoxic activities of all the isolated compounds were evaluated by MTT assay. Compounds 1, 2, 8, 9, and 10 possess varying degrees of selective cytotoxicity against HL-60, HepG2, BGC-823, and A2780 cell lines.[Formula: see text].

journal_name

J Asian Nat Prod Res

authors

Li Y,Dong C,Xu MJ,Lin WH

doi

10.1080/10286020.2018.1540604

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

121-130

issue

2

eissn

1028-6020

issn

1477-2213

journal_volume

22

pub_type

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