Three 11,12-seco-tanshinone derivatives from the rhizomes of Salvia miltiorrhiza.

Abstract:

:Three new compounds named tanshinoic acid A (1), tanshinoic acid B (2), and tanshinoic acid C (3) were isolated from the rhizomes of Salvia miltiorrhiza, together with two known compounds methyl salvianolate A (4) and methyl salvianolate C (5). Their structures were determined on the basis of spectroscopic data (UV, IR, HRESIMS, 1 D and 2 D NMR). The in vitro assay indicated that 4 and 5 could improve the survived rate of cells on oxygen glucose deprivation (OGD) induced neurons damage model and glutamate-induced neurons damage model at a concentration of 10 μM. [Formula: see text].

journal_name

J Asian Nat Prod Res

authors

Gu QC,Yin ZK,Feng ZM,Jiang JS,Zhang X,Zhang PC,Yang YN

doi

10.1080/10286020.2020.1799988

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

935-940

issue

10

eissn

1028-6020

issn

1477-2213

journal_volume

22

pub_type

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