Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor.

Abstract:

:Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that the uptake ratio of andrographolide was less than 2.0 at all concentrations tested, indicating that andrographolide is not a hOAT1 substrate. Andrographolide has no significant effects on the p-aminohippuric acid uptake and on the mRNA and protein expression of hOAT1. In conclusion, andrographolide may not pose a drug-herb interaction risk related to hOAT1.

journal_name

J Asian Nat Prod Res

authors

Chong YM,Kaur G,Tan ML

doi

10.1080/10286020.2018.1520704

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

754-771

issue

8

eissn

1028-6020

issn

1477-2213

journal_volume

21

pub_type

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