Abstract:
:Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that the uptake ratio of andrographolide was less than 2.0 at all concentrations tested, indicating that andrographolide is not a hOAT1 substrate. Andrographolide has no significant effects on the p-aminohippuric acid uptake and on the mRNA and protein expression of hOAT1. In conclusion, andrographolide may not pose a drug-herb interaction risk related to hOAT1.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Chong YM,Kaur G,Tan MLdoi
10.1080/10286020.2018.1520704subject
Has Abstractpub_date
2019-08-01 00:00:00pages
754-771issue
8eissn
1028-6020issn
1477-2213journal_volume
21pub_type
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