Constituents from the roots of Heracleum rapula Franch.

abstract：:Liver is the largest metabolic organ for a wide range of endogenous and exogenous compounds and plays a crucial part in the pharmacokinetics and pharmacodynamics through various metabolic reactions. This review provides a progressive description of hepatic metabolism of herbal drugs with respect to metabolic types and...

journal_title：Journal of Asian natural products research

authors： Peng YS,Liu B,Wang RF,Zhao QT,Xu W,Yang XW

更新日期：2015-01-01 00:00:00

abstract：:Two new C21 steroidal glycosides were isolated from Cynanchum wallichii Wight. Their structures were elucidated as caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-digitoxopyranoside (1) and caudatin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-ole...

journal_title：Journal of Asian natural products research

authors： Wang D,Pan WH,Bao YR,Yang XX,Meng XS

更新日期：2014-01-01 00:00:00

abstract：:Two new quinochalcone glycosides, hydroxysafflor yellow A-4'-O-β-D-glucopyranoside (1) and 3'-hydroxyhydroxysafflor yellow A (2), were isolated from the safflower yellow pigments of Carthamus tinctorius. The structures of new compounds were elucidated by a detailed spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D ...

journal_title：Journal of Asian natural products research

authors： Zhang H,Duan CP,Luo X,Feng ZM,Yang YN,Zhang X,Jiang JS,Zhang PC

更新日期：2020-12-01 00:00:00

abstract：:Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4-12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1-3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated f...

journal_title：Journal of Asian natural products research

authors： Li L,Xie MP,Sun H,Lu AQ,Zhang B,Zhang D,Wang SJ

更新日期：2019-10-01 00:00:00

abstract：:A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity agai...

journal_title：Journal of Asian natural products research

authors： Chai MY

更新日期：2020-03-01 00:00:00

abstract：:Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most s...

journal_title：Journal of Asian natural products research

authors： Zhao F,He EQ,Wang L,Liu K

更新日期：2008-05-01 00:00:00

abstract：:A phytochemical study on the seeds of Cassia obtusifolia was carried out, which finally led to obtain two naphthalenes (1 and 2), two naphthopyrans (3 and 4) and twelve anthraquinones (5-16). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence. A...

journal_title：Journal of Asian natural products research

authors： Pang X,Li NN,Yu HS,Kang LP,Yu HY,Song XB,Fan GW,Han LF

更新日期：2019-10-01 00:00:00

abstract：:A new angular dihydropyrancoumarin named wulongensin A, along with five known coumarins, (-)-anomalin, umbelliferone, (-)-smyrinol, 3'(S),4'(S)-disenecioyloxy-3',4'-dihydroseselin, (+)-trans-khellactone, was isolated from the root of Peucedanum wulongense. The structure of wulongensin A was established as 3'(R)-angelo...

journal_title：Journal of Asian natural products research

authors： Kong LY,Zhi F

更新日期：2003-09-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the major causative agent of hand foot and mouth disease. And EV71 causes epidemics worldwide, particularly in the Asia-Pacific region. Unfortunately, currently there is no approved vaccine or antiviral drug for EV71-induced disease prevention and therapy. In screening for anti-EV71 candidates...

journal_title：Journal of Asian natural products research

authors： Wang HQ,Meng S,Li ZR,Peng ZG,Han YX,Guo SS,Cui XL,Li YH,Jiang JD

更新日期：2013-01-01 00:00:00

abstract：:Seven new C14-polyacetylene glucosides codonopilodiynosides A-G (1-7) were isolated from an aqueous extract of the Codonopsis pilosula roots. Their structures were determined by spectroscopic and chemical methods as (-)-(5S,6E,12E)-tetradeca-6,12-dien-8,10-diyn-1,5,14-triol 5-O-β-D-glucopyranoside (1), (-)-(5S,6E,12E)...

journal_title：Journal of Asian natural products research

authors： Jiang YP,Liu YF,Guo QL,Jiang ZB,Xu CB,Zhu CG,Yang YC,Lin S,Shi JG

更新日期：2015-01-01 00:00:00

abstract：:One kinds of glycolipid (SBI) have been isolated from the marine brown alga Sargassum hemiphyllum (Turn.) Ag. The structures of SBI have been determined as the sodium salt of 1-0-acyl-3-0-(6'-sulfo-alpha-D-quinovopyrannosyl) glycerol (acyl: tetradecanoyl, pentadecanoyl, 11-hexadecenoyl, hexadecanoyl, 10,13-octadecadie...

journal_title：Journal of Asian natural products research

authors： Cui Z,Li YS,Liu HB,Yuan D,Lu BR

更新日期：2001-01-01 00:00:00

abstract：:A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy...

journal_title：Journal of Asian natural products research

authors： Zhang L,Liu MS,Huang J,Li GY,Zhang C,Dong L,Zhang K,Wang JH

更新日期：2014-01-01 00:00:00

abstract：:A new phenanthraquinone, named bauhinione (1), has been isolated from Bauhinia variegata L., and its structure has been elucidated as 2,7-dimethoxy-3-methyl-9,10-dihydrophenanthrene-1,4-dione on the basis of spectroscopic analysis. ...

journal_title：Journal of Asian natural products research

authors： Zhao YY,Cui CB,Cai B,Han B,Sun QS

更新日期：2005-12-01 00:00:00

abstract：:Biotransformation of podophyllotoxin (PT) by several microbial species has been investigated. Among the fungi tested, it was found that Penicillium strains can isomerize PT to picropodophyllin (PPT) in 8% yield and other strains also transform the substrate into the same product but with lower yield. ...

journal_title：Journal of Asian natural products research

authors： Guo HZ,Guo DA,Fei XY,Cui YJ,Zheng JH

更新日期：1998-01-01 00:00:00

abstract：:Two new indole-diterpenoids named penijanthine B and penitrem H were isolated from the metabolites of the fungus Penicilliumcrustosum YN-HT-15, which was isolated from the red soil of Yunnan Province of China. The structures were determined on spectroscopic analyses and CD spectra. ...

journal_title：Journal of Asian natural products research

authors： Su SS,Song AH,Chen G,Wang HF,Li ZQ,Pei YH

更新日期：2014-01-01 00:00:00

abstract：:Two new (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates (7 and 8) were synthesized and evaluated for biological activity. Compound 8 showed highly potent anticancer activity against A-549 cell line with IC50 of 2.16 ± 1.02 μM, which displayed the highest selectivity index value (SI = 14.5) in A-54...

journal_title：Journal of Asian natural products research

authors： Zi CT,Yang L,Hu Y,Zhang P,Tang H,Zhang BL,Shen XJ,Kong QH,Wang Y,Wang XJ,Sheng J

更新日期：2020-07-03 00:00:00

abstract：:In this letter, (R)-muscone and (S)-muscone were prepared by optical resolution of dl-muscone using N,N'-dibenzyl-l-tartaramide or N,N'-dibenzyl-d-tartaramide, according to the method reported by Kunihiko Takabe. But we separated the diastereomers using EtOH instead of MeOH in the recrystallization step to get the goa...

journal_title：Journal of Asian natural products research

authors： Meng Y,Xiao Q,Bai JY,Xiao X,Zhang S,Zhu XY,Cheng GF,Yin DL

更新日期：2014-12-01 00:00:00

abstract：:Chemical investigation on the cultures of Phellinus tuberculosus and Laetiporus sulphureus lead to the isolation of two new illudin-type sesquiterpenoids (phellinuin J and sulphureuine A). Their structures were elucidated by 1D, 2D NMR and MS spectroscopic data. These compounds were purposely evaluated for their cytot...

journal_title：Journal of Asian natural products research

authors： He JB,Tao J,Miao XS,Feng YP,Bu W,Dong ZJ,Li ZH,Feng T,Liu JK

更新日期：2015-01-01 00:00:00

abstract：:A new natural coumarin, angepubebisin (1), and a new furan, angepubefurin (2), together with the five known compounds, umbelliferone, angelol B (3), ulopterol (4), peucedanol (5), and scopoletin, were isolated from the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan. The structures of angepubebisin (1) an...

journal_title：Journal of Asian natural products research

authors： Yang XW,Zhang CY,Zhang BG,Lu Y,Luan JW,Zheng QT

更新日期：2009-08-01 00:00:00

abstract：:Four new oleanane type saponins, monepalosides G-J (1-4), were isolated from the water-soluble part of the whole plant of Morina nepalensis var. alba Hand-Mazz. On the basis of chemical and spectroscopic evidence, their structures were determined as 3-O-alpha-L-arabinopyranosyl-(1 --> 3)-alpha-L-arabinopyranosyl olean...

journal_title：Journal of Asian natural products research

authors： Teng RW,Xie HY,Liu XK,Wang DZ,Yang CR

更新日期：2003-06-01 00:00:00

abstract：:Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells an...

journal_title：Journal of Asian natural products research

authors： Tai BH,Cuong NM,Huong TT,Choi EM,Kim JA,Kim YH

更新日期：2009-09-01 00:00:00

abstract：:Two new metabolites, pyrenocine J (1) and pyrenochaetic acid D (2), together with two known metabolites, pyrenocine A (3) and pyrenochaetic acid A (4), were isolated from a soil fungus, Curvularia affinis strain HS-FG-196. Their structures were established by extensive spectroscopic analysis. Compound 1 showed cytotox...

journal_title：Journal of Asian natural products research

authors： Zhang H,Mao LL,Qian PT,Shan WG,Wang JD,Bai H

更新日期：2012-01-01 00:00:00

abstract：:The loss of glutamate transporter-1 (GLT-1) is associated with temporal lobe epilepsy (TLE). A recent study reported that Hsp90β interacted with GLT-1 and recruited it to 20S proteasome for degradation. Therefore, inhibiting Hsp90β may be a new strategy for treating epilepsy. So far, no studies have shown whether the ...

journal_title：Journal of Asian natural products research

authors： Peng YC,Wang S,Zhang Y,Huang LJ,Wang XL,Peng Y

更新日期：2019-09-01 00:00:00

abstract：:A new minor sesquiterpene lactone glucoside, ixerin ZA (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6'-(p-metheoxyphenylacetyl)]-beta-glucopyranoside on the basis of sp...

journal_title：Journal of Asian natural products research

authors： He WF,Xu BB,Pan JC,Lu JC,Song SJ,Xu SX

更新日期：2006-09-01 00:00:00

abstract：:Four new C19-diterpenoid alkaloids, hemaconitines A-D (1-4), were isolated from the roots of Aconitum hemsleyanum var. circinatum. Their structures were elucidated as 19R-hydroxyl-secoyunnaconitine (1), (3R)-hydroxyl-liwaconitine (2), 14-anisoyl-leucanthumsine E (3), and 19R -acetonyl-8-O-methyltalatisamine (4) by ext...

journal_title：Journal of Asian natural products research

authors： He D,Liu WY,Xiong J,Xu JJ,Shen Y

更新日期：2019-09-01 00:00:00

abstract：:Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1-5 showed growth inhibitory activi...

journal_title：Journal of Asian natural products research

authors： Cui CB,Yan SY,Cai B,Yao XS

更新日期：2002-12-01 00:00:00

abstract：:Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by ...

journal_title：Journal of Asian natural products research

authors： Guan SH,Xia JM,Yang M,Wang XM,Liu X,Guo DA

更新日期：2008-07-01 00:00:00

abstract：:One new naturally occurring 7-membered 2,5-dioxopiperazine alkaloid named (+)-cyclopenol (1), along with nine known compounds including viridicatol (2), 3-(dimethylaminomethyl)-1-(1,1-dimethyl-2-propenyl)indole (3), anacine (4), aurantiomide C (5), viridicatin (6), 3-O-methylviridicatin (7), verrucosidin (8), ergoster...

journal_title：Journal of Asian natural products research

authors： Li J,Wang J,Jiang CS,Li G,Guo YW

更新日期：2014-01-01 00:00:00

abstract：:Two new C-glucosyl flavonoids 6''-O-feruloylspinosin and 6''-O-feruloyl-6'''-p-hydroxybenzoylspinosin, together with five known compounds, were isolated from the seeds of Ziziphus jujube (Rhamnaceae family). Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1-7 showed mod...

journal_title：Journal of Asian natural products research

authors： Fu Q,Ma Y,Chen J,Yuan HM,Zheng YZ

更新日期：2017-05-01 00:00:00

abstract：:Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and nodakenetin, were investigated. The irritant potential was explored by open mou...

journal_title：Journal of Asian natural products research

authors： Saeed MA,Sabir AW

更新日期：2008-01-01 00:00:00