Abstract:
:Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1-5 showed growth inhibitory activity (1, IC50 25 microg/ml) on human fibrosarcoma HT-1080 cells and cell cycle M-phase inhibitory (2, MIC 0.78 microg/ml) and apoptosis inducing (2, MIC 1.56 microg/ml; 3, MIC 25 microg/ml; 4, MIC 20 microg/ml; 5, MIC 30 microg/ml) activities on mouse tsFT210 cells, respectively, and 2-5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Cui CB,Yan SY,Cai B,Yao XSdoi
10.1080/1028602021000049041keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
233-41issue
4eissn
1028-6020issn
1477-2213journal_volume
4pub_type
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