Resolution and chiral recognition of muscone as well as actions on neural system.

Abstract:

:In this letter, (R)-muscone and (S)-muscone were prepared by optical resolution of dl-muscone using N,N'-dibenzyl-l-tartaramide or N,N'-dibenzyl-d-tartaramide, according to the method reported by Kunihiko Takabe. But we separated the diastereomers using EtOH instead of MeOH in the recrystallization step to get the goal product with higher optical purity and yield. The regulatory effect of muscone and its enantiomer on the neural system showed that they could prolong mouse hypoxia tolerance and dose-dependently enhance mouse spinal cord stimulation induced by strychnine nitrate. (R)-muscone and (S)-muscone had a synergistic action on shortening sleep time induced by sodium pentobarbital in mice.

journal_name

J Asian Nat Prod Res

authors

Meng Y,Xiao Q,Bai JY,Xiao X,Zhang S,Zhu XY,Cheng GF,Yin DL

doi

10.1080/10286020.2014.996141

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1166-70

issue

12

eissn

1028-6020

issn

1477-2213

journal_volume

16

pub_type

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