Abstract:
:Two new lignan glycosides forsythiayanoside A (1) and forsythiayanoside B (2), one new stereoisomer of lignan glycoside (+)-8-hydroxyepipinoresinol-4-O-β-D-glucopyranoside (3), together with seven known compounds (4-10), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. Compounds 4 and 10 were isolated from this species for the first time. The structures of 1-3 were elucidated on the basis of chemical and spectral analyses, including 1D and 2D NMR data and HR-ESI-MS. The absolute configurations were determined by the circular dichroism method. All isolates were tested for their cytotoxicities against five human cancer cell lines (A549, Colo-205, Hep-3B, HL60, and KB). In particular, compound 3 showed significant cytotoxicity with IC50 values of 9.48, 7.75, 0.59, 4.06, and 38.38 μM, respectively.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Yan XJ,Peng Y,Liu ZX,Wen J,Liu QB,Li LZ,Song SJdoi
10.1080/10286020.2014.917631subject
Has Abstractpub_date
2014-01-01 00:00:00pages
602-10issue
6eissn
1028-6020issn
1477-2213journal_volume
16pub_type
杂志文章abstract::Verticilliside (1), a new flavone C-glucoside, has been isolated from the ethyl acetate soluble fraction of Enicostemma verticillatum and its structure is assigned on the basis of the spectroscopic data. 5,7,4'-Trihydroxyflavone 8-C-beta-D-glucopyranoside (2) and isoorientin 3'-O-methyl ether (3) have also been isolat...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020802675019
更新日期:2009-01-01 00:00:00
abstract::Two new apianen lactones, named as guanyeliaoine I (1) and guanyeliaoine II (2), have been isolated along with seven known compounds from Polygonum perforliatum L. (Chinese name "Guanyeliao", Berberidaceae). Their structures were deduced on the basis of spectral data and chemical methods. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/1028602042000324844
更新日期:2007-03-01 00:00:00
abstract::Phytochemical analysis of the high quality Chinese agarwood 'Qi-Nan' originating from Aquilaria sinensis (Lour.) Glig led to the isolation of a new 2-(2-phenylethyl)chromone derivative, qinanones G (1), and four known 2-(2-phenylethyl)chromones (2-5). Their structures were elucidated by spectroscopic techniques (UV, I...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.896342
更新日期:2014-01-01 00:00:00
abstract::The investigation of chemical constituents from the branches of Calophyllum inophyllum Linn led to the isolation of a new prenylated xanthone, named caloxanthone Q (1), together with three known compounds, 2-deprenylrheediaxanthone B (2), jacareubin (3), and 6-deoxyjacareubin (4). Their structures were completely eluc...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2010.550884
更新日期:2011-03-01 00:00:00
abstract::One new flavone, 5,7-dihydroxy-8,2',3',6'-tetramethoxyflavone (1), and one new flavonol, 5,7,6'-trihydroxy-2'-methoxyflavonol (2), were isolated from the roots of Scutellaria baicalensis, and their structures were elucidated on the basis of extensive spectroscopic evidences, especially 1D and 2D NMR and HR-ESI-MS expe...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.999048
更新日期:2015-01-01 00:00:00
abstract::An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C10-type polyacetylene glycosides (1-4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2-4 w...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2016.1247811
更新日期:2017-02-01 00:00:00
abstract::The loss of glutamate transporter-1 (GLT-1) is associated with temporal lobe epilepsy (TLE). A recent study reported that Hsp90β interacted with GLT-1 and recruited it to 20S proteasome for degradation. Therefore, inhibiting Hsp90β may be a new strategy for treating epilepsy. So far, no studies have shown whether the ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2018.1530989
更新日期:2019-09-01 00:00:00
abstract::A new phenyldihydronaphthalene-type lignan, vitexdoin F (1), along with 22 known lignan derivatives (2-23) was isolated from the seeds of Vitex negundo var. cannabifolia. Their structures were established by comprehensive 1D and 2D NMR spectroscopic analyses. The antioxidant activities of these lignans were evaluated ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.929574
更新日期:2014-01-01 00:00:00
abstract::Two new polyketides, 3,11-dihydroxy-6,8-dimethyldodecanoic acid (1) and trichopyrone B (2), together with two known polyketides, sorbicillin (3) and penicillone A (4), have been isolated from the cultures broth of the fungus Penicillium decumbens. Their structures were elucidated by extensive spectroscopic analysis. A...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2018.1424139
更新日期:2018-05-01 00:00:00
abstract::Three new alkylated benzoquinones, 2-hydroxy-5-ethoxy-3-nonyl-1,4-benzoquinone (1), 5-O-butyl-embelin (2), and 2,5-dihydroxy-6-methyl-3-pentadecyl-1,4-benzoquinone (3), together with seven known analogues (4-10), were isolated from the stems and twigs of mangrove plant, Aegiceras corniculatum. Their structural elucida...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2018.1540604
更新日期:2020-02-01 00:00:00
abstract::Three new ursane-type triterpenoids, 2α,3β-dihydroxy-11α,12α-epoxy-urs-28,13β-olide (1), 2α,3β,24-trihydroxy-11α,12α-epoxy-urs-28,13β-olide (2), and 2α,3α,24-trihydroxy-11,20(30)-dien-urs-28,13β-olide (6), together with six known ursane-type triterpenoids (3-5, 7-9), were isolated from the EtOAc extract of the aerial ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2013.837458
更新日期:2013-09-01 00:00:00
abstract::A new oleanane type triterpene characterized as 3α, 24-diacetoxy-12-oleanene (1) together with known compounds 2-10, were isolated from Annona mucosa leaf extracts. Their structural elucidation was accomplished using physical and spectroscopic methods. The compounds showed weak to moderate insecticidal activities agai...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2020.1818726
更新日期:2020-09-15 00:00:00
abstract::A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamine and 10 novel-substituted 3-benzylmercapto-1,2,4-triazol derivatives were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS, and X-ray. Most substituted 3-benz...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2020.1754400
更新日期:2020-05-07 00:00:00
abstract::Nine new fatty acid derivatives, including seven methoxylated (1, 2, and 4-8) and two hydroxylated (3 and 9) fatty acids, have been isolated from the ethanol extract of the stem bark of Fraxinus sieboldiana. Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. The 3- ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.648622
更新日期:2012-01-01 00:00:00
abstract::A new benzofuran-type lignan, vitrifol A (1), was isolated from the fruits of Vitex trifolia, along with three known compounds 2-4. Their structures were elucidated mainly on the basis of 1D, 2D NMR and MS spectral data. Compound 1 was first isolated as a dimer of dihydrobenzofuran-type lignan. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020801967359
更新日期:2008-05-01 00:00:00
abstract::Two new sesquiterpenoids, 4,5-epoxy-13-methoxy-1(10)-germacren-12,6-olide and 4,5-epoxy-13-acetoxy-1(10)-germacren-12,6-olide, were isolated from the leaves of Magnolia grandiflora, together with six known compounds, 2alpha-hydroxy-dihydroparthenolide, parthenolide, costunolide, syringaresinol, (+) medioresinol and 6,...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020108041376
更新日期:2001-01-01 00:00:00
abstract::Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2016.1170813
更新日期:2016-09-01 00:00:00
abstract::A new ester, 2-(4'-hydroxyphenyl)ethyl dotriacontanoate (1), and a new inseparable mixture of octacosan-1,28-dioldiferulate and triacontan-1,30-dioldiferulate (2) were isolated from the stem barks of Stereospermum acuminatissimum, along with 24 known compounds including 4 triterpenoids, 11 anthraquinones, 2 lignans, 3...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.619182
更新日期:2011-12-01 00:00:00
abstract::Muricatenol (1) is a new C37 non-THF ring acetogenin with four hydroxyls and one isolated double bond in the long aliphatic chain. 2,4-cis-Gigantetrocinone (2) and 2,4-trans-gigantetrocinone (3) have been isolated as their acetates by preparative TLC. 2,4-trans-Isoannonacin-10-one (4) and 2,4-trans-isoannonacin (5) ha...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020108040366
更新日期:2001-01-01 00:00:00
abstract::Three new alkaloids namely 8-(4-hydroxyphenyl)-6-methoxy-3,4-dihydroisoquinolin-1(2H)-one (1), 4-aminonigellidine (2), and N-[(4-hydroxy-2-isopropyl-5-methyl)]phenylurea (3), along with six known ones (4-9), were isolated from the seeds of Nigella glandulifera. The structures of 1-3 were determined through spectroscop...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2016.1184654
更新日期:2017-01-01 00:00:00
abstract::During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50 = 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell line...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2016.1228633
更新日期:2017-05-01 00:00:00
abstract::Three new sesquiterpenoids (1-3), along with four known compounds (4-7), were isolated from cultures of the fungus Conocybe siliginea. The structures of new compounds were elucidated using spectroscopic methods. The known compounds were identified by comparing their spectroscopic data with those reported in the litera...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.939072
更新日期:2015-01-01 00:00:00
abstract::The relationship between the immunological activities and their surface activities of octadecanoyl acetal sodium sulphite series containing different numbers of double bonds (HOU-C18:n; n = 1, Delta9; n = 2, Delta9,12; n = 3, Delta9,12,15) were studied. The results showed that HOU-C18:n were able to increase the carbo...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020500289659
更新日期:2007-01-01 00:00:00
abstract::(+)-Lariciresinol 3a-acetate [(+)-(3S)-acetyloxymethyl-(2S)-(4-hydroxy-3-methoxyphenyl)-(4R)-[(4-hydroxy-3-methoxyphenyl)methyl]tetrahydrofuran] (1), a metabolite of A. elaeagnoidea was synthesized starting from (-)-lariciresinol (2) in three steps with an overall yield of 66%. ...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020008039904
更新日期:2000-01-01 00:00:00
abstract::In this letter, (R)-muscone and (S)-muscone were prepared by optical resolution of dl-muscone using N,N'-dibenzyl-l-tartaramide or N,N'-dibenzyl-d-tartaramide, according to the method reported by Kunihiko Takabe. But we separated the diastereomers using EtOH instead of MeOH in the recrystallization step to get the goa...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2014.996141
更新日期:2014-12-01 00:00:00
abstract::Four new oleanane-type triterpenoid saponins, cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (1), cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-glucopyranosyl-(1 -->...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020802144719
更新日期:2008-09-01 00:00:00
abstract::Three new flavonol glycosides, kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside (1), kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (2), and kaempferol-3-O-(6-trans-p-coumaroyl)-beta-D-glucopyranosyl-(1 --> 2)-...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/1028602042000325627
更新日期:2006-01-01 00:00:00
abstract::Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined wit...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2015.1117452
更新日期:2016-01-01 00:00:00
abstract::Three new acetylated anthraquinone glycosides (1-3) were isolated from the seed of Cassia obtusifolia, together with one parent anthraquinone glycoside (1a). Their structures were determined on the basis of spectroscopic methods and physicochemical properties as obtusifoline-2-O-β-d-2, 6-di-O-acetylglucopyranoside (1)...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2011.570264
更新日期:2011-06-01 00:00:00
abstract::A new prenylated coumarin (1) and a new anthranilamide derivative (2) were isolated from the aerial parts of Evodia lepta. Compound 2 represents the first anthranilamide derivative from the Evodia genus. Their structures were elucidated by spectroscopic data analysis (MS, UV, IR, and NMR). Compound 1 exhibited certain...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2019.1670169
更新日期:2020-05-01 00:00:00