Effect of octadecanoyl acetal sodium sulphite series with different numbers of double bonds on their immunological and surface activities.

Abstract:

:The relationship between the immunological activities and their surface activities of octadecanoyl acetal sodium sulphite series containing different numbers of double bonds (HOU-C18:n; n = 1, Delta9; n = 2, Delta9,12; n = 3, Delta9,12,15) were studied. The results showed that HOU-C18:n were able to increase the carbon granular clearance rate K, the NK cell activity in spleen and the activity of lysozymes in serum as well as inhibit Staphylococcus aureus and lysozymes in vitro to some degree. As the number of double bonds in HOU-C18:n increased along with the hydrophobic properties and the ability to improve the immune activity, NK cell activity and lysozyme activity decreased, but the bacteriostatic activity increased. It is speculated that HOU-C18:n could improve immunity and bacteriostasis realised by the interaction between the hydrophobic chain and membranes of cells. From the results of the effects of HOU-C18:n on lysozymes in vivo and in vitro, it is speculated that HOU-C18:0 could initiate and greatly enhance lysozyme activity in serum by increasing the amount of lysozymes, while unsaturated HOU-C18:n might do so mainly by increasing the number of lysozymes.

journal_name

J Asian Nat Prod Res

authors

Yuan LJ,Ye XL,Li XG,He HM

doi

10.1080/10286020500289659

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

49-58

issue

1

eissn

1028-6020

issn

1477-2213

pii

772059734

journal_volume

9

pub_type

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