Synthesis and structure-activity relationship of theasapogenol galactosides against Magnaporthe oryzae.

Abstract:

:Camellia oleifera is expected to provide alternative aglycone to synthesize some saponins similar to that from Schima superba with inhibitory activity against Magnaporthe oryzae. Eight theasapogenol galactosides were synthesized via protection of adjacent hydroxyl groups by a benzylidene for regioselective glycosylation in the multi-hydroxyl sapogenin. Water soluble galactose chain connected far from liposoluble end was a key group in inhibiting the growth of M. oryzea unless theasapogenol was modified by two galactosyl groups or by one galactosyl group and one benzylidene group. The amphoteric characteristics of saponin such as saccharide group number, distance between bipolar groups play an important role in inhibiting mycelium growth of M. oryzae.

journal_name

J Asian Nat Prod Res

authors

Huo GH,Chen XT,Li ZM,Liu CF,Xiao DJ

doi

10.1080/10286020.2017.1325877

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

128-138

issue

2

eissn

1028-6020

issn

1477-2213

journal_volume

20

pub_type

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