Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells.

Abstract:

:Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P < 0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

journal_name

J Asian Nat Prod Res

authors

Tai BH,Cuong NM,Huong TT,Choi EM,Kim JA,Kim YH

doi

10.1080/10286020903117317

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

817-23

issue

9

eissn

1028-6020

issn

1477-2213

pii

914961157

journal_volume

11

pub_type

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