Abstract:
:A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels-Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1) and kuwanon R (2) by means of spectroscopic methods. Both compounds strongly inhibited nuclear transcription factor.κB activity with the IC₅₀ values of 4.65 and 7.38 μM, respectively.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Phung TX,Tran TH,Dan TT,Chau VM,Hoang TH,Nguyen TDdoi
10.1080/10286020.2012.670221subject
Has Abstractpub_date
2012-01-01 00:00:00pages
596-600issue
6eissn
1028-6020issn
1477-2213journal_volume
14pub_type
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journal_title:Journal of Asian natural products research
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