New guaianolides from Artemisia anomala.

Abstract:

:Two new guaianolides artemanomalides A and B were isolated from the aerial parts of Artemisia anomala S. Moore. Their structures were characterized as 2-oxo-5α, 10α-dihydroxy-guaia-3-en-1α, 6β, 7α, 11β H-12, 6-olide (1) and 8α-acetoxy-2-oxo-5α, 10α-dihydroxy-guaia-3, 11(13)-dien-1α, 6β, 7αH-12, 6-olide (2) on the basis of extensive spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities against COX-2 enzyme with IC(50) values of 8.8 and 3.6 μM.

journal_name

J Asian Nat Prod Res

authors

Hu ZH,Zhang P,Huang DB,Wu JZ

doi

10.1080/10286020.2011.634802

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

111-4

issue

2

eissn

1028-6020

issn

1477-2213

journal_volume

14

pub_type

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