Abstract:
:A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3β,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark of Aglaia angustifolia Miq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1) showed strongest cytotoxic activity with an IC50 value of 50.5 μg/ml.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Hutagaol RP,Harneti D,Safari A,Hidayat AT,Supratman U,Awang K,Shiono Ydoi
10.1080/10286020.2020.1776704subject
Has Abstractpub_date
2020-06-13 00:00:00pages
1-8eissn
1028-6020issn
1477-2213pub_type
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