Two new sesquiterpene derivatives from Chinese eaglewood.

Abstract:

:Two new sesquiterpene derivatives, (+)-8β-hydroxy-longicamphenylone (1) and 11β-hydroxy-13-isopropyl-dihydrodehydrocostus lactone (2), were isolated from Chinese eaglewood. Their structures were elucidated on the basis of spectroscopic analyses including HR-ESI-MS, (1)H and (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOE. The two compounds exhibited potent anti-depressant activity in vitro by inhibiting [(3)H]-5-HT reuptake in rat brain synaptosomes by 54.8% and 51.9%, respectively, at 10 μM.

journal_name

J Asian Nat Prod Res

authors

Yang L,Qiao LR,Zhang JJ,Dai JG,Guo SX

doi

10.1080/10286020.2012.704910

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1054-8

issue

11

eissn

1028-6020

issn

1477-2213

journal_volume

14

pub_type

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