Abstract:
:Two new sesquiterpene derivatives, (+)-8β-hydroxy-longicamphenylone (1) and 11β-hydroxy-13-isopropyl-dihydrodehydrocostus lactone (2), were isolated from Chinese eaglewood. Their structures were elucidated on the basis of spectroscopic analyses including HR-ESI-MS, (1)H and (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOE. The two compounds exhibited potent anti-depressant activity in vitro by inhibiting [(3)H]-5-HT reuptake in rat brain synaptosomes by 54.8% and 51.9%, respectively, at 10 μM.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Yang L,Qiao LR,Zhang JJ,Dai JG,Guo SXdoi
10.1080/10286020.2012.704910subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1054-8issue
11eissn
1028-6020issn
1477-2213journal_volume
14pub_type
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