Abstract:
:We present the synthesis of enantiomerically pure (S)-α-methyl-serine methyl ester hydrochloride from 2-methyl-3-((4-(trifluoromethyl)benzyl)oxy)propanal and di-p-chlorobenzyl azodicarboxylate via asymmetrically catalyzed amination with naphthylalanine derivative catalyst. The application of the organocatalyst of D-3-(1-Naphthyl)-alanine is the key step in the synthesis and ensures the product is obtained with high levels of stereocontrol.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Xiao Q,Tang YF,Xie Pdoi
10.1080/10286020.2019.1634058subject
Has Abstractpub_date
2020-01-01 00:00:00pages
61-68issue
1eissn
1028-6020issn
1477-2213journal_volume
22pub_type
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