An efficient enantioselective synthesis of (S)-α-methyl-serine methyl ester hydrochloride via asymmetrically catalyzed amination.

Abstract:

:We present the synthesis of enantiomerically pure (S)-α-methyl-serine methyl ester hydrochloride from 2-methyl-3-((4-(trifluoromethyl)benzyl)oxy)propanal and di-p-chlorobenzyl azodicarboxylate via asymmetrically catalyzed amination with naphthylalanine derivative catalyst. The application of the organocatalyst of D-3-(1-Naphthyl)-alanine is the key step in the synthesis and ensures the product is obtained with high levels of stereocontrol.

journal_name

J Asian Nat Prod Res

authors

Xiao Q,Tang YF,Xie P

doi

10.1080/10286020.2019.1634058

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

61-68

issue

1

eissn

1028-6020

issn

1477-2213

journal_volume

22

pub_type

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