Abstract:
OBJECTIVE:To investigate the efficacy of true fast imaging with steady state precession (true-FISP) compared with T2-weighted fast spin echo (T2W-FSE) in monitoring changes in cyst volume and renal expansion in an ischemia reperfusion (IR) injured PKD1 knockout (IKO) mouse model. MATERIALS AND METHODS:The animal study was approved by the local institutional authority. A total of 24 mice (14 PKD1 IKO mice and 10 control mice) were sequentially scanned on a 4.7-T scanner from 4 to 12 weeks after IR injury and the cysts and kidney volumes were measured from true-FISP and T2W-FSE MR images. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for the images generated from both methods. RESULTS:Cyst SNR and CNR in true-FISP images were significantly higher than in images employing the T2W-FSE sequence (P < 0.05). Both methods demonstrated kidney volume increase as well as cyst growth after IR injury in the mouse model. The kidney and cysts volume at different time points were strongly correlated between true-FISP and T2W-FSE measurements (r(kidney) = 0.99, r(cysts) = 0.97). CONCLUSION:The true-FISP method offers shorter scan times and higher cyst SNR and cyst to kidney tissue contrast than T2W-FSE. Both sequences have identical accuracy in measuring the cysts and kidney volume changes in mice with PKD.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Zhou X,Bao H,Takakura A,Zhou J,Albert M,Sun Ydoi
10.1097/RLI.0b013e3181be3501subject
Has Abstractpub_date
2010-01-01 00:00:00pages
24-8issue
1eissn
0020-9996issn
1536-0210journal_volume
45pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to investigate the impact of a novel iterative denoising and image enhancement technique in T1-weighted precontrast and postcontrast volume-interpolated breath-hold examination (VIBE) of the abdomen on image quality, noise levels, and diagnostic confidence without change of acquisit...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000746
更新日期:2020-11-18 00:00:00
abstract:RATIONALE AND OBJECTIVES:The relative stability and selectivity of magnetic resonance (MR) imaging contrast agents were compared with in vitro transmetallation and ligand competition reactions. MATERIALS AND METHODS:A gadolinium (Gd)-DTPA-BIGA, Gd-DTPA-BMA, Gd-DTPA, or Gd-HP-DO3A solution was mixed with an equimolar s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199610000-00003
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:To test the technique and feasibility of translating tumor suspicious region maps in the prostate, obtained by multimodality, anatomic, and functional 3T magnetic resonance imaging (MRI) data to 32-channel coil, T2-weighted (T2-w), 3T MR images, for directing MR-guided biopsies. Furthermore, to evaluate the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31817d0506
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000381
更新日期:2017-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Hepatocellular carcinomas (HCCs) usually consist of components of different histologic grade. Using surgically resected specimens, the authors obtained high-resolution magnetic resonance (MR) images and studied the relationship between histologic grade of HCCs and MR signal intensity. METHOD:I...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199308000-00007
更新日期:1993-08-01 00:00:00
abstract::The large intestines of eight boxer dogs with canine histiocytic ulcerative colitis (CHUC) and 10 normal dogs were studied by in vivo angiography and postmortem microangiography. The vascular abnormalities were correlated with the gross and histologic pathology found at necropsy. The angiographic abnormalities were ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197505000-00005
更新日期:1975-05-01 00:00:00
abstract::Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract::Using real-time ultrasound, the motions of the tongue, hyoid bone, and larynx were monitored and timed during swallowing in ten normal subjects. A well-defined propulsive wave of the tongue was observed during swallowing a 5-cc water bolus. The body of the hyoid bone was identified on the ultrasound scan as a high ech...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198403000-00003
更新日期:1984-03-01 00:00:00
abstract::The association of GE Medical Systems and the AUR represents a unique collaboration between academic radiology and industry that bears important potential for elevating the quality of clinical research in radiology and developing a cadre of high-quality radiologist researchers for the future. The establishment of the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199305000-00001
更新日期:1993-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:The authors performed a retrospective study in ultrasound to investigate new aspects in the sonomorphology of lymph node metastases of the neck. In this study, it could be demonstrated the first time that the histologic characteristics of the metastases determine the sonographic appearance. In a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199609000-00001
更新日期:1996-09-01 00:00:00
abstract::This paper presents a microcomputer-based technique that accurately quantifies volumes from computed tomographic (CT) scans of irregularly shaped objects as well as displaying 3-D reconstructions. The method uses standard CT film, allowing analysis of previous or outside CT studies. The planimetry method showed less t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198812000-00001
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000064
更新日期:2014-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate image mottle in conventional CT images of the abdomen as a function of radiographic technique factors and patient size. METHODS:Water-filled phantoms simulating the abdomens of adult (32 cm in diameter) and pediatric (16 cm in diameter) patients were used to investigate image mo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199904000-00005
更新日期:1999-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To develop a computer-assisted analysis of complex joint motion based on standard fluoroscopic sequences. MATERIALS AND METHODS:Fluoroscopic sequences of 10 normal shoulders and 20 patients after total shoulder arthroplasty were recorded during abduction and adduction. The analysis of the shou...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200202000-00004
更新日期:2002-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To develop a simple and robust helium3 polarization system dedicated to small animal imaging. To demonstrate the potential of helium3 imaging for pulmonary ventilation and perfusion studies. METHODS:A home-built polarization system based on spin-exchange technique was used. This system was app...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the performance of black-blood diffusion-weighted (DW)-EPI sequences with parallel imaging for the detection of focal liver lesions in comparison with a standard T2-weighted (T2-w) sequence. MATERIALS AND METHODS:Twenty patients with known or suspected focal liver lesions underwent liver MRI usi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31816200b5
更新日期:2008-04-01 00:00:00
abstract::Three methods are presented which provide statistically acceptable estimates of mean transit time of opacified blood during angiography. While the methods vary in precision, the selection of the method appropriate for any particular experimental model depends on the degree of precision required to demonstrate the effe...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197707000-00004
更新日期:1977-07-01 00:00:00
abstract::The application of intravenous, intrathecal, and inhalation enhancement techniques to the CT evaluation of the nonhuman primate (Papio cynocephalus/anubis) is described. The falx cerebri cortical vasculature, vein of Galen, straight sinus and tentorium cerebelli were defined with intravenous enhancement. Intrathecal C...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00014
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000009
更新日期:2014-03-01 00:00:00
abstract::Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D2O, and in tumor adenosine triphosphate (ATP), measured by 31P ma...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198912000-00022
更新日期:1989-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The efficacy of gadoteridol for contrast enhancement of central nervous system pathology was assessed in a multicenter clinical trial involving 411 patients suspected of having intracranial or spinal pathology. METHODS:Magnetic resonance imaging was performed before and after intravenous admin...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1992-08-01 00:00:00
abstract::Even though we have made much progress over the last decade, much still needs to be done. I am personally very pleased with the excellent management and authority of my coauthor, Joe Frank, in assuming the Acting Directorship of our DRRP. You will be hearing more from him in the immediate future about this research pr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199304001-00014
更新日期:1993-04-01 00:00:00
abstract::The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198211000-00007
更新日期:1982-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors differentiate breast lesions on sonography by measurements in two compression states that are perpendicular to each other. METHODS:Diameters of 100 breast lesions were measured preoperatively under lateromedial and craniocaudal compression with a new sonographic method. This method...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199607000-00003
更新日期:1996-07-01 00:00:00
abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00004
更新日期:1979-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess whether differences in cerebral atrophy and white matter lesions or in the presence of lactate and lipid signals can explain the observed differences in brain choline, creatine, and N-acetylaspartate levels between healthy elderly women and men. METHODS:In addition to standard magnet...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200110000-00005
更新日期:2001-10-01 00:00:00
abstract::The potential of magnetic resonance imaging (MRI) quantification of calcium for the evaluation of pulmonary nodules was investigated in simulated nodules. Calcium salts do not contain mobile protons and thus have no signal on MR proton images. To determine whether the absence of signal from partially calcified nodules...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198711000-00001
更新日期:1987-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare the diagnostic efficacy of a standard dose of MRI contrast agent in the evaluation of primary brain tumors and metastases using a high-field 3 tesla MR unit versus a 1.5 tesla MR unit. METHODS:Sixteen patients with brain tumors were examined at both field strengths using identical a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200203000-00003
更新日期:2002-03-01 00:00:00
abstract::Breast calcification diagnosis was studied by using clinical findings and computerized image processing of a mammogram in a network of trained expert learning systems (Outcome Advisor [OA]). The system was tested with records not used for training and performance was compared with radiologist. The network was 72% accu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199106000-00004
更新日期:1991-06-01 00:00:00
abstract::The hardcopy recording technologies of video cameras, slow-scan (digital spot) recorders, and laser film printers are presented and compared. Slow-scan (digital spot) recorders offer a few advantages when compared with multiformat video cameras. But only laser film printers provide the high-quality hardcopy recordings...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199102000-00017
更新日期:1991-02-01 00:00:00