Abstract:
:The past decade has seen a significant increase in the incidence of invasive fungal infections. The antifungal armamentarium for the treatment of serious fungal infections remains limited. A possible approach to overcoming antifungal drug resistance and high mortality rates seen in severe fungal infections is to combine two or three classes of antifungals, especially if the drugs have different mechanisms of action. Combinations of new agents along with more traditional antifungals have now been shown to possess some synergistic or at least additive activity against many fungi in in vitro and animal studies. On the other hand, caution is still needed since some antifungal combinations have also demonstrated antagonistic activity. Well-controlled clinical trials are still required to define the most efficacious antifungal regimen. Furthermore, these trials should also evaluate the side-effect potential of combination regimens and the pharmacoeconomic impact these regimens may have.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Vazquez JAdoi
10.2217/17460913.2.2.115subject
Has Abstractpub_date
2007-04-01 00:00:00pages
115-39issue
2eissn
1746-0913issn
1746-0921journal_volume
2pub_type
杂志文章,评审abstract:AIM:To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile o...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0160
更新日期:2017-05-01 00:00:00
abstract::Coxsackieviruses are important human pathogens, and their interactions with the innate and adaptive immune systems are of particular interest. Many viruses evade some aspects of the innate response, but coxsackieviruses go a step further by actively inducing, and then exploiting, some features of the host cell respons...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.101
更新日期:2010-09-01 00:00:00
abstract:AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in...
journal_title:Future microbiology
pub_type: 杂志文章,多中心研究
doi:10.2217/fmb.11.158
更新日期:2012-02-01 00:00:00
abstract::Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.72
更新日期:2015-01-01 00:00:00
abstract:AIM:To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source. MATERIALS & METHODS:The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscop...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0245
更新日期:2018-12-01 00:00:00
abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0167
更新日期:2019-09-01 00:00:00
abstract::Evaluation of: Kang S-M, Yoo D-G, Lipatov AS et al.: Induction of long-term protective immune responses by influenza H5N1 virus-like particles. PLoS ONE 4, e4667 (2009). This article describes a long-term protective effect of a vaccine candidate against avian influenza H5N1 that is based on A/Viet Nam1203/04 proteins ...
journal_title:Future microbiology
pub_type: 评论,杂志文章
doi:10.2217/fmb.09.33
更新日期:2009-06-01 00:00:00
abstract::Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/17460913.3.1.19
更新日期:2008-02-01 00:00:00
abstract::Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-re...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.131
更新日期:2016-01-01 00:00:00
abstract:: Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded comp...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.13.140
更新日期:2014-01-01 00:00:00
abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/17460913.4.2.145
更新日期:2009-03-01 00:00:00
abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.77
更新日期:2010-08-01 00:00:00
abstract:AIMS:AFN-1252 is a novel inhibitor of FabI, an essential enzyme in Staphylococcus spp. This study was undertaken to assess the safety, tolerability and pharmacokinetic properties of AFN-1252, following oral administration in an ascending dose trial. MATERIALS & METHODS:This was a double-blind, randomized, placebo-cont...
journal_title:Future microbiology
pub_type: 杂志文章,随机对照试验
doi:10.2217/fmb.15.101
更新日期:2015-01-01 00:00:00
abstract::Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0157
更新日期:2019-11-01 00:00:00
abstract::Among the 33 confirmed Bartonella species to date, more than half are hosted by rodent species, and at least five of them have been involved in human illness causing diverse symptoms including fever, myocarditis, endocarditis, lymphadenitis and hepatitis. In almost all countries, wild rodents are infected by extremely...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.77
更新日期:2013-09-01 00:00:00
abstract::In this exclusive interview, Simon Gaisford discusses his current research into gut dysbiosis and its possible relevance to disease states, as well as the efficacy of probiotic supplementation and its possible use as treatment. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. ...
journal_title:Future microbiology
pub_type: 面试
doi:10.2217/fmb-2019-0016
更新日期:2019-03-01 00:00:00
abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.15
更新日期:2010-03-01 00:00:00
abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...
journal_title:Future microbiology
pub_type:
doi:10.2217/fmb.10.142
更新日期:2010-12-01 00:00:00
abstract::Aim: Antibiotic resistance in Mycobacterium abscessus renders treatment poorly effective. Despite erm(41)-gene-mediated macrolide resistance, treatment with azithromycin or clarithromycin is recommended. It is contested whether macrolides differ in erm(41) induction. We determine whether this is the case. Methods:M. a...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0310
更新日期:2019-06-01 00:00:00
abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0134
更新日期:2019-08-01 00:00:00
abstract::Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.43
更新日期:2013-06-01 00:00:00
abstract::Resistance continues to emerge as a leading cause for antiretroviral treatment failure. Several mutations in HIV reverse transcriptase (RT) confer resistance to non-nucleoside inhibitors (NNRTIs), vital components of antiretroviral combination therapies. Since the majority of mutations are located in the NNRTI binding...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.122
更新日期:2015-01-01 00:00:00
abstract::There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gu...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/FMB.15.54
更新日期:2015-01-01 00:00:00
abstract::Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.73
更新日期:2011-08-01 00:00:00
abstract::Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.12.9
更新日期:2012-03-01 00:00:00
abstract::Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-formi...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0299
更新日期:2019-07-01 00:00:00
abstract::Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0128
更新日期:2016-12-01 00:00:00
abstract:AIM:To describe a predictive model to obtain the area under the plasma concentration versus time curve (AUC) for micafungin to aid in dosing strategies in pediatric patients. METHODS:Using published pharmacokinetic data a linear regression model to describe the Cmax versus AUCtau was developed. The mean absolute error...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.16.3
更新日期:2016-01-01 00:00:00
abstract::Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0266
更新日期:2020-06-01 00:00:00
abstract::Surgical procedures for the symptomatic removal of the gallbladder and the vermiform appendix have been posited to adversely shift the assemblage of the intestinal microbiome increasing the risk of disease. The associated mechanisms have been linked with dysbiosis of the gut microbiota. Cholecystectomy causes changes ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0325
更新日期:2020-05-01 00:00:00