Myxopyronin: a punch in the jaws of bacterial RNA polymerase.

Abstract:

:Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacterial RNA polymerase is an essential enzyme, which is responsible for synthesizing RNA from a DNA template and is targeted by a number of antibiotics. The mechanism of action of two closely related transcription inhibitors, myxopyronin B and a synthetic analog desmethyl-myxopyronin was elucidated, together with the structures of the antibiotic-RNA polymerase complexes. The studies reveal a new binding site and a new mechanism of action affecting the jaw domain of the enzyme. As the need for new antibiotics increase, these studies open new ways to the synthesis of more potent myxopyronin analogs.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Tupin A,Gualtieri M,Brodolin K,Leonetti JP

doi

10.2217/17460913.4.2.145

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

145-9

issue

2

eissn

1746-0913

issn

1746-0921

journal_volume

4

pub_type

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