Abstract:
:Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila, an intracellular pathogen that coevolved with protozoan hosts, encodes a large arsenal of secreted effectors conferring the ability to evade host cellular defenses and to manipulate them to promote invasion and intracellular replication. Conservation of many signaling pathways of protozoa in human macrophages confers the ability of L. pneumophila to infect humans, causing a severe pneumonia called legionnaires' disease. Most of the secreted proteins are delivered by the Dot/Icm type IV secretion system and several of these have been shown to act on different cellular pathways critical for infection. Moreover, multiple effectors target a single host function to orchestrate bacterial survival. In this review, we focus on those effectors in the repertoire of L. pneumophila proteins that target key cellular pathways by specific post-translational modifications.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Rolando M,Buchrieser Cdoi
10.2217/fmb.12.9subject
Has Abstractpub_date
2012-03-01 00:00:00pages
369-81issue
3eissn
1746-0913issn
1746-0921journal_volume
7pub_type
杂志文章,评审abstract::Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0085
更新日期:2020-07-01 00:00:00
abstract::The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine c...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.22
更新日期:2010-04-01 00:00:00
abstract::West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.67
更新日期:2014-01-01 00:00:00
abstract:AIM:This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of China. MATERIALS & METHODS:Multilocus sequence typing was performed. RESULTS:Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0060
更新日期:2018-09-01 00:00:00
abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0134
更新日期:2019-08-01 00:00:00
abstract::Malaria remains a major international health challenge. Resistance to a number of existing drugs and evidence of the emergence of artemisinin resistance has emphasized the need for new antimalarials. A new approach has been the preparation of dual-function compounds that include a chloroquine-like antimalarial group a...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.18
更新日期:2013-04-01 00:00:00
abstract:AIM:To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. MATERIALS & METHODS:A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract i...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0144
更新日期:2017-05-01 00:00:00
abstract::Capabilities in mass spectrometry are evolving rapidly, with recent improvements in sensitivity, data analysis and, most important from the standpoint of this review, much higher throughput, allowing analysis of many samples in a single day. This short review describes how these improvements in mass spectrometry can b...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.3.6.625
更新日期:2008-12-01 00:00:00
abstract::Aim: Face masks are an important addition to our arsenal in the fight against COVID-19. The aim of this study is to present a novel method of measuring mask performance which can simultaneously assess both fabric penetration and leakage due to poor fit. Materials & methods: A synthetic aerosol is introduced into the l...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0292
更新日期:2021-01-01 00:00:00
abstract::Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective aga...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.78
更新日期:2015-01-01 00:00:00
abstract::Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.83
更新日期:2015-01-01 00:00:00
abstract::Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-imp...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0120
更新日期:2017-01-01 00:00:00
abstract:AIMS:Glucuronoxylomannan (GXM) is the major polysaccharide component of Cryptococcus neoformans. We evaluated in this study whether GXM fractions of different molecular masses were functionally distinct. MATERIALS & METHODS:GXM samples isolated from C. neoformans cultures were fractionated to generate polysaccharide p...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.13.163
更新日期:2014-01-01 00:00:00
abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.3
更新日期:2014-01-01 00:00:00
abstract:: Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded comp...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.13.140
更新日期:2014-01-01 00:00:00
abstract::Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0275
更新日期:2020-07-01 00:00:00
abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.77
更新日期:2010-08-01 00:00:00
abstract::Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.123
更新日期:2013-12-01 00:00:00
abstract:AIM:Raman spectroscopy is an analytical method with a broad range of applications across multiple scientific fields. We report on a possibility to differentiate between two important Gram-positive species commonly found in clinical material - Staphylococcus aureus and Staphylococcus epidermidis - using this rapid nonin...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0224
更新日期:2017-08-01 00:00:00
abstract::Aim: Cryptococcosis causes significant morbidity and mortality worldwide, but pediatric data are limited. Methods: A retrospective literature review of Australian pediatric cryptococcosis and additional 10-year audit of cases from a large pediatric network. Results: 22 cases of cryptococcosis in children were identifi...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0215
更新日期:2019-12-01 00:00:00
abstract::Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...
journal_title:Future microbiology
pub_type:
doi:10.2217/fmb-2018-0202
更新日期:2018-10-01 00:00:00
abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.36
更新日期:2015-01-01 00:00:00
abstract::Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0046
更新日期:2020-09-01 00:00:00
abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.15
更新日期:2010-03-01 00:00:00
abstract::Salmonella enterica is an invasive, facultative intracellular gastrointestinal pathogen causing human diseases such as gastroenteritis and typhoid fever. Virulence-attenuated strains of this pathogen have interesting capacities for the generation of live vaccines. Attenuated live typhoidal and nontyphoidal Salmonella ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.144
更新日期:2012-01-01 00:00:00
abstract:AIM:To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. METHODS:95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. RESULTS:The isolates showed a high diversity (IOD 0.964) w...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0013
更新日期:2016-07-01 00:00:00
abstract::During its productive infection, HSV-1 dramatically remodels the architecture and physiology of the host cell nucleus. The immediate-early proteins, the first viral proteins to be expressed during infection, are key players in this process. Here, we review the known properties and functions of immediate-early protein ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.4
更新日期:2013-03-01 00:00:00
abstract::A common complication of antibiotic use is the development of gastrointestinal disease. This complication ranges from mild diarrhea to pseudomembranous colitis. Outbreaks of antibiotic-associated diarrhea (AAD) may also occur in healthcare settings, usually caused by Clostridium difficile. AAD typically occurs in 5-35...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.3.5.563
更新日期:2008-10-01 00:00:00
abstract::Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.89
更新日期:2014-01-01 00:00:00
abstract::Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2017-0170
更新日期:2018-03-01 00:00:00