Abstract:
:Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-forming unit (CFU) of vaginal lavage was measured by plating. The extent of the inflammatory response was assessed by hematoxylin-eosin (H&E) staining and enzyme-linked immunosorbent assay (ELISA). Results: GE had an inhibitory effect on the proliferation of C. albicans and inflammatory reaction. Meanwhile, it had a potentially beneficial effect on the growth of Lactobacillus. Conclusion: These results showed the potential application of GE as an antifungal agent in VVC treatment.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Cai X,Kong F,Wang R,Zhai S,Guan X,Zhang G,Wang Ddoi
10.2217/fmb-2018-0299subject
Has Abstractpub_date
2019-07-01 00:00:00pages
839-846eissn
1746-0913issn
1746-0921journal_volume
14pub_type
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