Potential for adaptation overrides cost of resistance.

Abstract:

AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolutionary parameters estimated from their frequencies along time. RESULTS & CONCLUSION:Costly resistance mutations were found to coexist with lower cost resistances for hundreds of generations, contrary to the hypothesis that the cost of a resistance dictates its extinction. Estimated evolutionary parameters for the different resistance backgrounds suggest a higher adaptive potential of clones with costly antibiotic resistance mutations, overriding their initial cost of resistance and allowing their maintenance in the absence of drugs.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Moura de Sousa J,Sousa A,Bourgard C,Gordo I

doi

10.2217/fmb.15.61

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1415-31

issue

9

eissn

1746-0913

issn

1746-0921

journal_volume

10

pub_type

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