Abstract:
AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in treating various fungal infections, its efficacy and safety in patients with invasive fungal infections remains to be further confirmed. MATERIALS & METHODS:In this study, we performed a multicenter, open-label clinical trial of posaconazole oral suspension in the treatment of 63 patients with invasive fungal infections who were refractory to or intolerant of first-line therapy. RESULTS:Our result showed that 64.4% of patients had a clinical response after posaconazole treatment, with 52.9% showing eradication of the fungal infection. The treatment caused some adverse effects of mild or moderate severity that were of short duration. CONCLUSION:The results of this trial indicate that posaconazole can be used in invasive fungal infections as an alternative or salvage therapy.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Huang X,Wang F,Chen Y,Liu T,Wang J,Hu J,Jie J,Chen F,Wang S,Shen Z,Yu L,Yu K,Liang Ydoi
10.2217/fmb.11.158subject
Has Abstractpub_date
2012-02-01 00:00:00pages
201-9issue
2eissn
1746-0913issn
1746-0921journal_volume
7pub_type
杂志文章,多中心研究abstract::Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, th...
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更新日期:2016-01-01 00:00:00
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.2.2.115
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00