Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence.

abstract：:Using the murine CMV animal model and the well-established model of Cre-lox-P-mediated green-fluorescence tagging of endothelial cell (EC)-derived mouse CMV to quantify the role of infected ECs in transplantation-associated CMV dissemination (in mice expressing Cre recombinase under the control of either the Tie2 or t...

journal_title：Future microbiology

authors： Gerna G

更新日期：2012-04-01 00:00:00

abstract：AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

journal_title：Future microbiology

authors： Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

更新日期：2018-06-01 00:00:00

abstract：:Over the last decade Raman spectroscopy has become established as a physicochemical technique for the rapid identification of microbes. This powerful analytical method generates a spectroscopic fingerprint from the microbial sample, which provides quantitative and qualitative information that can be used to characteri...

journal_title：Future microbiology

authors： Ashton L,Lau K,Winder CL,Goodacre R

更新日期：2011-09-01 00:00:00

abstract：AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...

journal_title：Future microbiology

authors： Xu S,Yang J,Yin C,Zhao X

更新日期：2018-02-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...

journal_title：Future microbiology

authors： Karampatakis T,Antachopoulos C,Tsakris A,Roilides E

更新日期：2017-07-01 00:00:00

abstract：AIM:We evaluated a Staphylococcus argenteus-specific diagnostic profile of matrix-assisted laser desorption/ionization time-of-flight mass spectrometer for accurate identification of this novel bacterium. MATERIALS & METHODS:Staphylococcus argenteus was identified based on negative crtM gene and presence of specific s...

journal_title：Future microbiology

authors： Chen SY,Lee H,Teng SH,Wang XM,Lee TF,Huang YC,Liao CH,Teng LJ,Hsueh PR

更新日期：2018-07-01 00:00:00

abstract：:Aim: Face masks are an important addition to our arsenal in the fight against COVID-19. The aim of this study is to present a novel method of measuring mask performance which can simultaneously assess both fabric penetration and leakage due to poor fit. Materials & methods: A synthetic aerosol is introduced into the l...

journal_title：Future microbiology

authors： Darby S,Chulliyallipalil K,Przyjalgowski M,McGowan P,Jeffers S,Giltinan A,Lewis L,Smith N,Sleator RD

更新日期：2021-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) manifestations remain important complications after allogeneic hematopoietic stem cell transplantation (HSCT), even in the current era. Unfortunately, available anti-CMV agents, mainly viral polymerase inhibitors, have a substantial risk of myelosuppression and nephrotoxicity. Letermovir, a novel...

journal_title：Future microbiology

authors： Hecke SV,Calcoen B,Lagrou K,Maertens J

更新日期：2019-02-01 00:00:00

abstract：:Some intracellular/membranous factors exert intrinsic immunity against viral pathogens. Most recently, SAMHD1 has been shown to be one of these factors. SAMHD1 is a nucleus-localized protein, and mutations in the gene are associated with Aicardi-Goutières syndrome. As a triphosphohydrolase, it depletes the intracellul...

journal_title：Future microbiology

authors： Chen Z,Zhang L,Ying S

更新日期：2012-09-01 00:00:00

abstract：:Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires pro...

journal_title：Future microbiology

authors： Taha MK,Deghmane AE

更新日期：2011-10-01 00:00:00

abstract：AIM:To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. METHODS & RESULTS:Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm forma...

journal_title：Future microbiology

authors： Bhargava N,Singh SP,Sharma A,Sharma P,Capalash N

更新日期：2015-01-01 00:00:00

abstract：:In this Phase I study, healthy volunteers (n = 24) were randomly allocated to receive either one or two 0.2-g applications per day (12 h apart) of ozenoxacin 2% cream on three different areas of the back for 3 consecutive days. Ozenoxacin concentrations were measured in tape stripping samples (from the stratum corneum...

journal_title：Future microbiology

authors： Gropper S,Albareda N,Santos B,Febbraro S

更新日期：2014-01-01 00:00:00

abstract：:The Enterococcus species is the third main cause of infective endocarditis (IE) worldwide, and it is gaining relevance, especially among healthcare-associated cases. Patients with enterococcal IE are older and have more comorbidities than other types of IE. Classical treatment options are limited due to the emergence ...

journal_title：Future microbiology

authors： Pericás JM,Zboromyrska Y,Cervera C,Castañeda X,Almela M,Garcia-de-la-Maria C,Mestres C,Falces C,Quintana E,Ninot S,Llopis J,Marco F,Moreno A,Miró JM

更新日期：2015-01-01 00:00:00

abstract：AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

journal_title：Future microbiology

authors： Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

更新日期：2013-02-01 00:00:00

abstract：AIM:To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo. MATERIALS & METHODS:The efficacy of ozenoxacin formulations was compared with vehicle control, mupi...

journal_title：Future microbiology

authors： Tarragó C,Esquirol LP,Arañó A,Lachamp L,D'Aniello F,Zsolt I

更新日期：2018-05-01 00:00:00

abstract：:Retapamulin is a semisynthetic pleuromutilin compound with in vitroactivity against Gram-positive bacteria, no cross-resistance to other classes of antimicrobial agents in current use and a low potential for development of resistance. A 1% ointment formulation has been developed for clinical use, and a placebo-control...

journal_title：Future microbiology

authors： Jacobs MR

更新日期：2007-12-01 00:00:00

abstract：AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

journal_title：Future microbiology

authors： Moura de Sousa J,Sousa A,Bourgard C,Gordo I

更新日期：2015-01-01 00:00:00

abstract：:Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...

journal_title：Future microbiology

authors： Tseng HK,Huang TY,Wu AY,Chen HH,Liu CP,Jong A

更新日期：2015-01-01 00:00:00

abstract：:Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

journal_title：Future microbiology

authors： Feldman C,Anderson R

更新日期：2006-10-01 00:00:00

abstract：:Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might ...

journal_title：Future microbiology

authors： Gouzy A,Poquet Y,Neyrolles O

更新日期：2014-01-01 00:00:00

abstract：:Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-imp...

journal_title：Future microbiology

authors： van der Eijk AA,Tintu AN,Hays JP

更新日期：2017-01-01 00:00:00

abstract：:The recent years have witnessed significant progress in the development of new drug candidates for the treatment of TB. While many of these are now in clinical trials, continued research is needed in order to sustain the drug discovery pipeline and meet the increasing needs of TB patients. These include shortening tre...

journal_title：Future microbiology

authors： Sala C,Hartkoorn RC

更新日期：2011-06-01 00:00:00

abstract：:Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...

journal_title：Future microbiology

authors： D'Amato F,Eldin C,Raoult D

更新日期：2016-01-01 00:00:00

abstract：:Coxiella burnetii is an extremely infectious, zoonotic agent that causes Q fever in humans. With the exception of New Zealand, the bacterium is distributed worldwide. Coxiella is classified as a select agent based on its past and potential use as a bioweapon and its threat to public health. Despite decades of research...

journal_title：Future microbiology

authors： Minnick MF,Raghavan R

更新日期：2011-11-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate epidemiology and susceptibility patterns of nosocomial Gram-positive infections in a referral teaching hospital. METHODS:Over a 1 year period, Gram-positive microorganisms isolated from specimens of hospitalized patients with documented nosocomial infection underwent antimicro...

journal_title：Future microbiology

authors： Soltani R,Khalili H,Abdollahi A,Rasoolinejad M,Dashti-Khavidaki S

更新日期：2012-07-01 00:00:00

abstract：AIM:Our aim is to investigate if the clusters of postsurgical mycobacterial infections, reported between 2004 and 2008 in seven geographically distant states in Brazil, were caused by a single mycobacterial strain. MATERIALS & METHODS:Available information from 929 surgical patients was obtained from local health auth...

journal_title：Future microbiology

authors： Leão SC,Viana-Niero C,Matsumoto CK,Lima KV,Lopes ML,Palaci M,Hadad DJ,Vinhas S,Duarte RS,Lourenço MC,Kipnis A,das Neves ZC,Gabardo BM,Ribeiro MO,Baethgen L,de Assis DB,Madalosso G,Chimara E,Dalcolmo MP

更新日期：2010-06-01 00:00:00

abstract：:Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were signific...

journal_title：Future microbiology

authors： Guo M,Yao J,Yang F,Liu W,Bai H,Ma J,Ma X,Zhang J,Fang Y,Miao Y,Sun J,Zhang Y,Zhao H

更新日期：2020-02-01 00:00:00

abstract：:Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...

journal_title：Future microbiology

authors： Ercibengoa M,Morales M,Alonso M,Ardanuy C,Marimón JM

更新日期：2019-07-01 00:00:00

abstract：:Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

journal_title：Future microbiology

authors： Lass-Flörl C

更新日期：2010-05-01 00:00:00

abstract：: Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded comp...

journal_title：Future microbiology

authors： Degang Y,Nakamura K,Akama T,Ishido Y,Luo Y,Ishii N,Suzuki K

更新日期：2014-01-01 00:00:00