Abstract:
:Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequencing was performed in PD patients with an unintended WL, in steady weight patients (non-WL [NWL]) and in matched normal subjects. KEGG functional predictions were carried out. Results: Microbiota profiles revealed a dissimilarity between WL and NWL. Moreover, WL pathways were characterized by fatty acid biosynthesis, while NWL by inflammation pathways. Conclusion: The gut microbiota could participate in weight alteration observed in PD by the presence of bacteria involved in weight gain and inflammation, or conversely by bacteria implicated in energy expenditure.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Del Chierico F,Grassini P,Quagliariello A,Torti M,Russo A,Reddel S,Stocchi Fdoi
10.2217/fmb-2019-0336subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1393-1404eissn
1746-0913issn
1746-0921journal_volume
15pub_type
杂志文章abstract::Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.73
更新日期:2011-08-01 00:00:00
abstract::The time is ripe to usher in a new paradigm in infection control and to move beyond our sole reliance on broad-spectrum antibiotics whose use results in extensive collateral damage to our microbiome and, in so doing, exerts significant selective pressures for resistance to emerge. We propose to supplement the existing...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.104
更新日期:2015-01-01 00:00:00
abstract::Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0280
更新日期:2020-08-01 00:00:00
abstract::Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires pro...
journal_title:Future microbiology
pub_type: 评论,杂志文章
doi:10.2217/fmb.11.103
更新日期:2011-10-01 00:00:00
abstract::Resistance continues to emerge as a leading cause for antiretroviral treatment failure. Several mutations in HIV reverse transcriptase (RT) confer resistance to non-nucleoside inhibitors (NNRTIs), vital components of antiretroviral combination therapies. Since the majority of mutations are located in the NNRTI binding...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.122
更新日期:2015-01-01 00:00:00
abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.36
更新日期:2015-01-01 00:00:00
abstract::Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies includin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.165
更新日期:2011-02-01 00:00:00
abstract::Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0157
更新日期:2019-11-01 00:00:00
abstract::The past decade has seen a significant increase in the incidence of invasive fungal infections. The antifungal armamentarium for the treatment of serious fungal infections remains limited. A possible approach to overcoming antifungal drug resistance and high mortality rates seen in severe fungal infections is to combi...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.2.2.115
更新日期:2007-04-01 00:00:00
abstract:AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0158
更新日期:2017-03-01 00:00:00
abstract:AIMS:We explored changes in antibiotic susceptibility of Serratia marcescens in the last 50 years by comparing isolates collected between 1945 and 1950, and current isolates. MATERIALS & METHODS:Isolates were divided into three groups: environmental, clinical and 'old'. Susceptibility was determined by microdilution. ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.12.40
更新日期:2012-06-01 00:00:00
abstract:AIM:To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. METHODS:95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. RESULTS:The isolates showed a high diversity (IOD 0.964) w...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0013
更新日期:2016-07-01 00:00:00
abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0134
更新日期:2019-08-01 00:00:00
abstract::Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.14.28
更新日期:2014-01-01 00:00:00
abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/17460913.4.2.145
更新日期:2009-03-01 00:00:00
abstract::Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0128
更新日期:2016-12-01 00:00:00
abstract::Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/17460913.3.1.19
更新日期:2008-02-01 00:00:00
abstract::The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and devel...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.12.126
更新日期:2013-01-01 00:00:00
abstract::Recognition of bacterial infection is the first key step to the initiation of an inflammatory response and host defense. Transmembrane proteins of the Toll-like receptor family have long been recognized as key detectors of the extracellular presence of pathogens. Recently, much research has identified a variety of int...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.4.1.65
更新日期:2009-02-01 00:00:00
abstract:AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2017-0070
更新日期:2018-02-01 00:00:00
abstract::Traditionally, glycoproteins have been considered the exclusive property of eukaryotes and archaea, but it is now evident that glycoproteins are found in all domains of life. In recent years N-linked glycosylation among some epsilon-proteobacteria has emerged as a new and exciting research area and represents a useful...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.09.10
更新日期:2009-05-01 00:00:00
abstract::In the past few months, there has been public discussion relating to a new perspective on blood safety and specifically upon measures to prevent or discourage donation by individuals with a diagnosis of myalgic encephalopathy-chronic fatigue syndrome. This reflects an intriguing interplay between science, public healt...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.11.24
更新日期:2011-04-01 00:00:00
abstract::Capabilities in mass spectrometry are evolving rapidly, with recent improvements in sensitivity, data analysis and, most important from the standpoint of this review, much higher throughput, allowing analysis of many samples in a single day. This short review describes how these improvements in mass spectrometry can b...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.3.6.625
更新日期:2008-12-01 00:00:00
abstract::Aim: Face masks are an important addition to our arsenal in the fight against COVID-19. The aim of this study is to present a novel method of measuring mask performance which can simultaneously assess both fabric penetration and leakage due to poor fit. Materials & methods: A synthetic aerosol is introduced into the l...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0292
更新日期:2021-01-01 00:00:00
abstract:AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dom...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0349
更新日期:2019-03-01 00:00:00
abstract::Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0046
更新日期:2020-09-01 00:00:00
abstract::Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2017-0170
更新日期:2018-03-01 00:00:00
abstract:AIM:A DNA microarray-based assay for the detection of antimicrobial resistance (AMR) genes was used to study carbapenemase-producing organisms at the Kidney Center of Rawalpindi, Pakistan. METHODS:The evaluation of this assay was performed using 97 reference strains with confirmed AMR genes. Testing of 7857 clinical s...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0082
更新日期:2018-09-01 00:00:00
abstract::West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.67
更新日期:2014-01-01 00:00:00
abstract:AIM:The purpose of current study is to find out relationship between cas9 gene and antimicrobial resistance in Campylobacter jejuni NCTC11168. MATERIALS & METHODS:The involvement of the cas9 gene in antimicrobial resistance of C. jejuni was determined by assessment of minimum inhibitory concentration, clustered regula...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0234
更新日期:2018-12-01 00:00:00