The impact of intestinal microbiota on weight loss in Parkinson's disease patients: a pilot study.

Abstract:

:Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequencing was performed in PD patients with an unintended WL, in steady weight patients (non-WL [NWL]) and in matched normal subjects. KEGG functional predictions were carried out. Results: Microbiota profiles revealed a dissimilarity between WL and NWL. Moreover, WL pathways were characterized by fatty acid biosynthesis, while NWL by inflammation pathways. Conclusion: The gut microbiota could participate in weight alteration observed in PD by the presence of bacteria involved in weight gain and inflammation, or conversely by bacteria implicated in energy expenditure.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Del Chierico F,Grassini P,Quagliariello A,Torti M,Russo A,Reddel S,Stocchi F

doi

10.2217/fmb-2019-0336

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1393-1404

eissn

1746-0913

issn

1746-0921

journal_volume

15

pub_type

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