Helicobacter pylori virulence factors in development of gastric carcinoma.

Abstract:

:Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different genotypes of H. pylori virulence factors. Thus far, many virulence factors of H. pylori, such as Cag PAI, VacA, OMPs and DupA, have been reported to be involved in the development of gastric cancer. The risk of developing gastric cancer during H. pylori infection is affected by specific host-microbe interactions that are independent of H. pylori virulence factors. In this review, we discuss virulence factors of H. pylori and their role in the development of gastric carcinoma that will provide further understanding of the biological interactions of H. pylori with the host.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Wang MY,Liu XF,Gao XZ

doi

10.2217/fmb.15.72

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1505-16

issue

9

eissn

1746-0913

issn

1746-0921

journal_volume

10

pub_type

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