Managing invasive fungal disease in immunocompromised patients.


:Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune function. Much has been achieved in the intervening years, and presentations on the challenges of invasive fungal disease at this year's ICHS congress reflected the changing nature of the population at risk of fungal disease, the growing range of fungal pathogens, and evolving approaches to the prevention, diagnosis and treatment of fungal infection.


Future Microbiol


Future microbiology


Maertens J,Bryan J




Has Abstract


2010-12-01 00:00:00












  • Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched Gastrodia elata extracts.

    abstract::Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-formi...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Cai X,Kong F,Wang R,Zhai S,Guan X,Zhang G,Wang D

    更新日期:2019-07-01 00:00:00

  • Myxopyronin: a punch in the jaws of bacterial RNA polymerase.

    abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tupin A,Gualtieri M,Brodolin K,Leonetti JP

    更新日期:2009-03-01 00:00:00

  • Do Aspergillus species produce biofilm?

    abstract::Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chandrasekar PH,Manavathu EK

    更新日期:2008-02-01 00:00:00

  • Gut permeability, its interaction with gut microflora and effects on metabolic health are mediated by the lymphatics system, liver and bile acid.

    abstract::There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Tran CD,Grice DM,Wade B,Kerr CA,Bauer DC,Li D,Hannan GN

    更新日期:2015-01-01 00:00:00

  • Tregs in the immune response of BALB/c mice experimentally infected with species of the Sporothrix genus.

    abstract::Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Corrêa-Moreira D,De Luca PM,Romeo O,C Menezes R,Paes RA,Oliveira RZ,de Moraes AM,de L Neto RG,Moraes Borba C,E de Oliveira MM

    更新日期:2020-09-01 00:00:00

  • Safety, tolerability and pharmacokinetics of AFN-1252 administered as immediate release tablets in healthy subjects.

    abstract:AIMS:AFN-1252 is a novel inhibitor of FabI, an essential enzyme in Staphylococcus spp. This study was undertaken to assess the safety, tolerability and pharmacokinetic properties of AFN-1252, following oral administration in an ascending dose trial. MATERIALS & METHODS:This was a double-blind, randomized, placebo-cont...

    journal_title:Future microbiology

    pub_type: 杂志文章,随机对照试验


    authors: Hafkin B,Kaplan N,Hunt TL

    更新日期:2015-01-01 00:00:00

  • Technologies for the development of West Nile virus vaccines.

    abstract::West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Ulbert S,Magnusson SE

    更新日期:2014-01-01 00:00:00

  • Use of the plaque assay for testing the antibiotic susceptibility of intracellular bacteria.

    abstract::The plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. Over time, the sensitivity and reproducibility of the technique has been improved. Usually, the number of...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Edouard S,Raoult D

    更新日期:2013-10-01 00:00:00

  • Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children.

    abstract::Retapamulin is a semisynthetic pleuromutilin compound with in vitroactivity against Gram-positive bacteria, no cross-resistance to other classes of antimicrobial agents in current use and a low potential for development of resistance. A 1% ointment formulation has been developed for clinical use, and a placebo-control...

    journal_title:Future microbiology

    pub_type: 临床试验,杂志文章


    authors: Jacobs MR

    更新日期:2007-12-01 00:00:00

  • Dosing antibiotics in neonates: review of the pharmacokinetic data.

    abstract::Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

    更新日期:2017-09-01 00:00:00

  • Lectins as virulence factors in Entamoeba histolytica and free-living amoebae.

    abstract::Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Guzmán-Téllez P,Martínez-Castillo M,Flores-Huerta N,Rosales-Morgan G,Pacheco-Yépez J,la Garza M,Serrano-Luna J,Shibayama M

    更新日期:2020-07-01 00:00:00

  • Epigenetics in the unicellular parasite Entamoeba histolytica.

    abstract::Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Tovy A,Ankri S

    更新日期:2010-12-01 00:00:00

  • Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates.

    abstract:AIM:To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. MATERIAL & METHODS:Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spati...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Freitas AI,Lopes N,Oliveira F,Brás S,França Â,Vasconcelos C,Vilanova M,Cerca N

    更新日期:2018-03-01 00:00:00

  • Folate metabolism as a source of molecular targets for antimalarials.

    abstract::Folate metabolism of the malaria parasites provides two targets for current antimalarials: dihydrofolate reductase and dihydropteroate synthase. Dihydrofolate reductase inhibitors have been used as antimalarials over the past few decades, often in combination with dihydropteroate synthase inhibitors. Resistance to the...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Yuthavong Y,Kamchonwongpaisan S,Leartsakulpanich U,Chitnumsub P

    更新日期:2006-06-01 00:00:00

  • The type IV secretion system in Helicobacter pylori.

    abstract::Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, th...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Yuan XY,Wang Y,Wang MY

    更新日期:2018-07-01 00:00:00

  • First fungemia case due to environmental yeast Wickerhamomyces myanmarensis: detection by multiplex qPCR and antifungal susceptibility.

    abstract:AIM:Presenting the first clinical case of Wickerhamomyces myanmarensis. PATIENTS & METHODS:Yeast cells were isolated from blood and central venous catheter of a 5.5-year-old male subject. API 20C AUX, MALDI-TOF MS, ITS and LSU rDNA sequencing, and our qPCR assay were used for identification and the MIC values were det...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Arastehfar A,Bakhtiari M,Daneshnia F,Fang W,Sadati SK,Al-Hatmi AM,Groenewald M,Sharifi-Mehr H,Liao W,Pan W,Zomorodian K,Hagen F,Boekhout T

    更新日期:2019-03-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Immediate outcomes of bacterial meningitis in childhood may benefit from slow initial β-lactam infusion and oral paracetamol.

    abstract::Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires pro...

    journal_title:Future microbiology

    pub_type: 评论,杂志文章


    authors: Taha MK,Deghmane AE

    更新日期:2011-10-01 00:00:00

  • Accurate differentiation of novel Staphylococcus argenteus from Staphylococcus aureus using MALDI-TOF MS.

    abstract:AIM:We evaluated a Staphylococcus argenteus-specific diagnostic profile of matrix-assisted laser desorption/ionization time-of-flight mass spectrometer for accurate identification of this novel bacterium. MATERIALS & METHODS:Staphylococcus argenteus was identified based on negative crtM gene and presence of specific s...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chen SY,Lee H,Teng SH,Wang XM,Lee TF,Huang YC,Liao CH,Teng LJ,Hsueh PR

    更新日期:2018-07-01 00:00:00

  • Detection of Helicobacter pylori in gastric cancer tissue through histopathology, immunohistochemistry and real-time reverse transcription-PCR.

    abstract::Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: A Castaneda C,Castillo M,Sanchez J,Casavilca S,Sanchez J,A Bernabe L,Suarez N,Chavez I,Ruiz E,Tello K,R Villa M,Zevallos R,Montenegro P,Dias-Neto E,Landa-Baella M,Taxa L

    更新日期:2020-08-01 00:00:00

  • Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.

    abstract:AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Correia I,Román E,Prieto D,Eisman B,Pla J

    更新日期:2016-01-01 00:00:00

  • Potentially pathogenic amoeba-associated microorganisms in cooling towers and their control.

    abstract::Cooling towers provide a favorable environment for the proliferation of microorganisms. Cooling towers generate a biofilm and often aerosolize contaminated water, thereby increasing the risk of microorganism dissemination by human inhalation. This pathogen dissemination was first revealed by the epidemics of Legionnai...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pagnier I,Merchat M,La Scola B

    更新日期:2009-06-01 00:00:00

  • Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the stimulated microgravity environment.

    abstract:AIM:To isolate and characterize the two phenotypically distinct subpopulations from Klebsiella pneumoniae clonal cultures grown in the simulate microgravity environment. MATERIALS & METHODS:Here clonal culture of K. pneumoniae strain ATCC BAA-1705 was grown within a vertically rotating wall vessel bioreactor. Microsco...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Wang H,Li W,Gu L,Gao X,Ni B,Deng H,Yang R,Han Y

    更新日期:2017-09-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00

  • Antibodies as a source of anti-infective peptides: an update.

    abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

    更新日期:2015-01-01 00:00:00

  • Skin tissue exposure of once- versus twice-daily topical ozenoxacin 2% cream: a Phase I study in healthy volunteers.

    abstract::In this Phase I study, healthy volunteers (n = 24) were randomly allocated to receive either one or two 0.2-g applications per day (12 h apart) of ozenoxacin 2% cream on three different areas of the back for 3 consecutive days. Ozenoxacin concentrations were measured in tape stripping samples (from the stratum corneum...

    journal_title:Future microbiology

    pub_type: 杂志文章,随机对照试验


    authors: Gropper S,Albareda N,Santos B,Febbraro S

    更新日期:2014-01-01 00:00:00

  • Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil.

    abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ramírez-Rueda RY,Marinho J,Salvador MJ

    更新日期:2019-09-01 00:00:00

  • Origin of hepatitis delta virus.

    abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Taylor J,Pelchat M

    更新日期:2010-03-01 00:00:00

  • Therapeutic efficacy of ozenoxacin in animal models of dermal infection with Staphylococcus aureus.

    abstract:AIM:To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo. MATERIALS & METHODS:The efficacy of ozenoxacin formulations was compared with vehicle control, mupi...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tarragó C,Esquirol LP,Arañó A,Lachamp L,D'Aniello F,Zsolt I

    更新日期:2018-05-01 00:00:00

  • Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.

    abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Dunn JD,Valdivia RH

    更新日期:2010-08-01 00:00:00