Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department.

Abstract:

:Aim: In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. Materials & methods: If subjects presented with febrile symptoms at the ED, 13 biomarkers' levels, including CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), were tested and compared with clinical records. Results: Among 50 subjects, 78% had bacterial infections and 8% had viral infections. nCD64 showed 82% sensitivity and 91% specificity for identifying subjects with bacterial infections. mCD169, HLA-ABC ratio and HLA-DR on monocytes had high values in subjects with viral infections. Conclusion: Biomarkers showed promising performances to improve the ED's infectious stratification.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Bourgoin P,Lediagon G,Arnoux I,Bernot D,Morange PE,Michelet P,Malergue F,Markarian T

doi

10.2217/fmb-2019-0256

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

189-201

eissn

1746-0913

issn

1746-0921

journal_volume

15

pub_type

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