Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.


:Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective against resistant organisms. Structures of efflux pumps bound to substrates and inhibitors have aided the design of compounds with lower affinity for the pump or inhibitors that more effectively block the pump. Structures of β-lactamase enzymes have revealed the mechanisms of action toward key carbapenems and structures of gyrase have aided the design of compounds that are less susceptible to point mutations.


Future Microbiol


Future microbiology


Reeve SM,Lombardo MN,Anderson AC




Has Abstract


2015-01-01 00:00:00












  • Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in Greece: an extended review (2000-2015).

    abstract::Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Karampatakis T,Antachopoulos C,Tsakris A,Roilides E

    更新日期:2017-07-01 00:00:00

  • Asaia lannensis bacteremia in a 'needle freak' patient.

    abstract::The genus Asaia has gained much interest lately owing to constant new species discoveries and its role as a potential opportunistic pathogen to humans. Here we describe a transient bacteremia due to Asaia lannensis in a patient with a psychiatric disorder (compulsive self-injection of different substances). Common phe...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Carretto E,Visiello R,Bardaro M,Schivazappa S,Vailati F,Farina C,Barbarini D

    更新日期:2016-01-01 00:00:00

  • Controversies in the treatment of pneumococcal community-acquired pneumonia.

    abstract::Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Feldman C,Anderson R

    更新日期:2006-10-01 00:00:00

  • Enterococcal endocarditis revisited.

    abstract::The Enterococcus species is the third main cause of infective endocarditis (IE) worldwide, and it is gaining relevance, especially among healthcare-associated cases. Patients with enterococcal IE are older and have more comorbidities than other types of IE. Classical treatment options are limited due to the emergence ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pericás JM,Zboromyrska Y,Cervera C,Castañeda X,Almela M,Garcia-de-la-Maria C,Mestres C,Falces C,Quintana E,Ninot S,Llopis J,Marco F,Moreno A,Miró JM

    更新日期:2015-01-01 00:00:00

  • SAMHD1: a novel antiviral factor in intrinsic immunity.

    abstract::Some intracellular/membranous factors exert intrinsic immunity against viral pathogens. Most recently, SAMHD1 has been shown to be one of these factors. SAMHD1 is a nucleus-localized protein, and mutations in the gene are associated with Aicardi-Goutières syndrome. As a triphosphohydrolase, it depletes the intracellul...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Chen Z,Zhang L,Ying S

    更新日期:2012-09-01 00:00:00

  • Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.

    abstract:AIM:To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. METHODS & RESULTS:Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm forma...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Bhargava N,Singh SP,Sharma A,Sharma P,Capalash N

    更新日期:2015-01-01 00:00:00

  • Managing invasive fungal disease in immunocompromised patients.

    abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...

    journal_title:Future microbiology



    authors: Maertens J,Bryan J

    更新日期:2010-12-01 00:00:00

  • Antibiotic-associated diarrhea: epidemiology, trends and treatment.

    abstract::A common complication of antibiotic use is the development of gastrointestinal disease. This complication ranges from mild diarrhea to pseudomembranous colitis. Outbreaks of antibiotic-associated diarrhea (AAD) may also occur in healthcare settings, usually caused by Clostridium difficile. AAD typically occurs in 5-35...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: McFarland LV

    更新日期:2008-10-01 00:00:00

  • Clinical metagenomics for the management of hospital- and healthcare-acquired pneumonia.

    abstract::The increasing burden of multidrug-resistant bacteria affects the management of several infections. In order to prescribe adequate antibiotics, clinicians facing severe infections such as hospital-acquired pneumonia (HAP) need to promptly identify the pathogens and know their antibiotic susceptibility profiles (AST), ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ruppé E,Baud D,Schicklin S,Guigon G,Schrenzel J

    更新日期:2016-01-01 00:00:00

  • First fungemia case due to environmental yeast Wickerhamomyces myanmarensis: detection by multiplex qPCR and antifungal susceptibility.

    abstract:AIM:Presenting the first clinical case of Wickerhamomyces myanmarensis. PATIENTS & METHODS:Yeast cells were isolated from blood and central venous catheter of a 5.5-year-old male subject. API 20C AUX, MALDI-TOF MS, ITS and LSU rDNA sequencing, and our qPCR assay were used for identification and the MIC values were det...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Arastehfar A,Bakhtiari M,Daneshnia F,Fang W,Sadati SK,Al-Hatmi AM,Groenewald M,Sharifi-Mehr H,Liao W,Pan W,Zomorodian K,Hagen F,Boekhout T

    更新日期:2019-03-01 00:00:00

  • Update on the epidemiological typing methods for Acinetobacter baumannii.

    abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rafei R,Osman M,Dabboussi F,Hamze M

    更新日期:2019-08-01 00:00:00

  • Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?

    abstract::Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Al-Dujaili LJ,Clerkin PP,Clement C,McFerrin HE,Bhattacharjee PS,Varnell ED,Kaufman HE,Hill JM

    更新日期:2011-08-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00

  • Use of the plaque assay for testing the antibiotic susceptibility of intracellular bacteria.

    abstract::The plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. Over time, the sensitivity and reproducibility of the technique has been improved. Usually, the number of...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Edouard S,Raoult D

    更新日期:2013-10-01 00:00:00

  • Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil.

    abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ramírez-Rueda RY,Marinho J,Salvador MJ

    更新日期:2019-09-01 00:00:00

  • Tuberculosis drugs: new candidates and how to find more.

    abstract::The recent years have witnessed significant progress in the development of new drug candidates for the treatment of TB. While many of these are now in clinical trials, continued research is needed in order to sustain the drug discovery pipeline and meet the increasing needs of TB patients. These include shortening tre...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Sala C,Hartkoorn RC

    更新日期:2011-06-01 00:00:00

  • Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering.

    abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...

    journal_title:Future microbiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bassetti M,Righi E,Pecori D,Tillotson G

    更新日期:2018-08-01 00:00:00

  • Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

    abstract:AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chen ZF,Ai LY,Wang JL,Ren LL,Yu YN,Xu J,Chen HY,Yu J,Li M,Qin WX,Ma X,Shen N,Chen YX,Hong J,Fang JY

    更新日期:2015-01-01 00:00:00

  • Micafungin sodium, the second of the echinocandin class of antifungals: theory and practice.

    abstract::Micafungin is a new drug in the echinocandin class and is currently being investigated in Phase III clinical trials. Like other echinocandins, it inhibits 1,3-beta-D-glucan synthesis, thus achieving fungicidal activity against virtually all Candida spp., including those resistant to fluconazole, and fungistatic activi...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Vehreschild JJ,Cornely OA

    更新日期:2006-08-01 00:00:00

  • Genetic and population analyses of Vibrio parahaemolyticus isolates from three major coastal regions in China.

    abstract:AIM:This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of China. MATERIALS & METHODS:Multilocus sequence typing was performed. RESULTS:Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li P,Xin W,Kang L,Chen Z,Guo C,Gao S,Yang H,Ji B,Yan Y,Wang H,Zhou D,Yang W,Wang J

    更新日期:2018-09-01 00:00:00

  • Promises and failures of gallium as an antibacterial agent.

    abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Minandri F,Bonchi C,Frangipani E,Imperi F,Visca P

    更新日期:2014-01-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Novel isoniazid derivative as promising antituberculosis agent.

    abstract::Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Volynets GP,Tukalo MA,Bdzhola VG,Derkach NM,Gumeniuk MI,Tarnavskiy SS,Yarmoluk SM

    更新日期:2020-07-01 00:00:00

  • Group A Streptococcus encounters with host macrophages.

    abstract::Group A Streptococcus (GAS) is a leading human bacterial pathogen with diverse clinical manifestations. Macrophages constitute a critical first line of host defense against GAS infection, using numerous surface and intracellular receptors such as Toll-like receptors and inflammasomes for pathogen recognition and activ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Valderrama JA,Nizet V

    更新日期:2018-01-01 00:00:00

  • Better than a pound of cure: preventing the development of multidrug-resistant tuberculosis.

    abstract::Diagnostic and treatment delays contribute to increased death and disability among the 490,000 adults and children who develop multidrug-resistant (MDR) tuberculosis every year. Since the treatment of MDR tuberculosis is complex, costly and often toxic, tuberculosis control programs should prioritize strategies to pre...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Byrne AL,Fox GJ,Marais BJ

    更新日期:2018-04-01 00:00:00

  • Lectins as virulence factors in Entamoeba histolytica and free-living amoebae.

    abstract::Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Guzmán-Téllez P,Martínez-Castillo M,Flores-Huerta N,Rosales-Morgan G,Pacheco-Yépez J,la Garza M,Serrano-Luna J,Shibayama M

    更新日期:2020-07-01 00:00:00

  • Cif type III effector protein: a smart hijacker of the host cell cycle.

    abstract::During coevolution with their hosts, bacteria have developed functions that allow them to interfere with the mechanisms controlling the proliferation of eukaryotic cells. Cycle inhibiting factor (Cif) is one of these cyclomodulins, the family of bacterial effectors that interfere with the host cell cycle. Acquired ear...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Samba-Louaka A,Taieb F,Nougayrède JP,Oswald E

    更新日期:2009-09-01 00:00:00

  • Natural history of Bartonella-infecting rodents in light of new knowledge on genomics, diversity and evolution.

    abstract::Among the 33 confirmed Bartonella species to date, more than half are hosted by rodent species, and at least five of them have been involved in human illness causing diverse symptoms including fever, myocarditis, endocarditis, lymphadenitis and hepatitis. In almost all countries, wild rodents are infected by extremely...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Buffet JP,Kosoy M,Vayssier-Taussat M

    更新日期:2013-09-01 00:00:00

  • Comparative evaluation of GeneXpert MTB/RIF and multiplex PCR targeting mpb64 and IS6110 for the diagnosis of pleural TB.

    abstract:AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

    更新日期:2018-03-01 00:00:00

  • Gut permeability, its interaction with gut microflora and effects on metabolic health are mediated by the lymphatics system, liver and bile acid.

    abstract::There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Tran CD,Grice DM,Wade B,Kerr CA,Bauer DC,Li D,Hannan GN

    更新日期:2015-01-01 00:00:00