Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.


:Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective against resistant organisms. Structures of efflux pumps bound to substrates and inhibitors have aided the design of compounds with lower affinity for the pump or inhibitors that more effectively block the pump. Structures of β-lactamase enzymes have revealed the mechanisms of action toward key carbapenems and structures of gyrase have aided the design of compounds that are less susceptible to point mutations.


Future Microbiol


Future microbiology


Reeve SM,Lombardo MN,Anderson AC




Has Abstract


2015-01-01 00:00:00












  • New insights into Prevotella diversity and medical microbiology.

    abstract::In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa w...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Alauzet C,Marchandin H,Lozniewski A

    更新日期:2010-11-01 00:00:00

  • Use of high-throughput mass spectrometry to elucidate host-pathogen interactions in Salmonella.

    abstract::Capabilities in mass spectrometry are evolving rapidly, with recent improvements in sensitivity, data analysis and, most important from the standpoint of this review, much higher throughput, allowing analysis of many samples in a single day. This short review describes how these improvements in mass spectrometry can b...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rodland KD,Adkins JN,Ansong C,Chowdhury S,Manes NP,Shi L,Yoon H,Smith RD,Heffron F

    更新日期:2008-12-01 00:00:00

  • Comparative evaluation of GeneXpert MTB/RIF and multiplex PCR targeting mpb64 and IS6110 for the diagnosis of pleural TB.

    abstract:AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

    更新日期:2018-03-01 00:00:00

  • Prediction of micafungin area under the curve data by using peak concentration: applicability and utility in antifungal therapy.

    abstract:AIM:To describe a predictive model to obtain the area under the plasma concentration versus time curve (AUC) for micafungin to aid in dosing strategies in pediatric patients. METHODS:Using published pharmacokinetic data a linear regression model to describe the Cmax versus AUCtau was developed. The mean absolute error...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Srinivas NR

    更新日期:2016-01-01 00:00:00

  • The dominance of bacterial genotypes leads to susceptibility variations under sublethal antibiotic pressure.

    abstract:AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Xu S,Yang J,Yin C,Zhao X

    更新日期:2018-02-01 00:00:00

  • Nosocomial infections in leukemic and solid-tumor cancer patients: distribution, outcome and microbial spectrum of anaerobes.

    abstract:AIMS:Nosocomial infections cause significant morbidity and mortality in cancer patients. As a result of their debilitated immune system, cancer patients are likely candidates for colonization with anaerobes. We sought to compare the distribution of nosocomial infections in neutropenic and non-neutropenic cancer patient...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: El-Sharif A,Elkhatib WF,Ashour HM

    更新日期:2012-12-01 00:00:00

  • The gut microbiome and the potentials of probiotics: an interview with Simon Gaisford.

    abstract::In this exclusive interview, Simon Gaisford discusses his current research into gut dysbiosis and its possible relevance to disease states, as well as the efficacy of probiotic supplementation and its possible use as treatment. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. ...

    journal_title:Future microbiology

    pub_type: 面试


    authors: Gaisford S

    更新日期:2019-03-01 00:00:00

  • Repertoire of human breast and milk microbiota: a systematic review.

    abstract::Breastfeeding is a major determinant of human health. Breast milk is not sterile and ecological large-scale sequencing methods have revealed an unsuspected microbial diversity that plays an important role. However, microbiological analysis at the species level has been neglected while it is a prerequisite before under...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Togo A,Dufour JC,Lagier JC,Dubourg G,Raoult D,Million M

    更新日期:2019-05-01 00:00:00

  • The composition of intestinal microbiota and its association with functional constipation of the elderly patients.

    abstract::Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were signific...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Guo M,Yao J,Yang F,Liu W,Bai H,Ma J,Ma X,Zhang J,Fang Y,Miao Y,Sun J,Zhang Y,Zhao H

    更新日期:2020-02-01 00:00:00

  • γ-irradiation from radiotherapy improves the virulence potential of Candida tropicalis.

    abstract:AIM:To evaluate if radiation used in radiotherapy can cause changes in the virulence potential of Candida tropicalis ATCC 750. MATERIALS & METHODS:C. tropicalis was exposed in vitro to identical dose and scheme of irradiation would be used in patients with head and neck cancer. Some virulence parameters were analyzed ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: da Silva EM,Kischkel B,Shinobu-Mesquita CS,Bonfim-Mendonça PS,Mansano ES,da Silva MA,Barbosa JF,Fiorini A,Hernandes L,Furlaneto MC,Svidzinski TI

    更新日期:2017-12-01 00:00:00

  • Origin of hepatitis delta virus.

    abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Taylor J,Pelchat M

    更新日期:2010-03-01 00:00:00

  • Inhibition of growth and gene expression in Staphylococcus aureus by anti-gyrA peptide nucleic acid.

    abstract::Aim: Multidrug-resistant Staphylococcus aureus isolates have become a serious concern in clinical microbiology. Antisense strategy, which specifically targets essential genes, could be helpful. Materials & methods:S. aureus cultures were treated with peptide conjugate-peptide nucleic acid (PPNA) specific for the gyrA ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tavakoli M,Hashemi A,Vaezjalali M,Mohammadzadeh M,Goudarzi H

    更新日期:2019-09-01 00:00:00

  • Novel isoniazid derivative as promising antituberculosis agent.

    abstract::Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Volynets GP,Tukalo MA,Bdzhola VG,Derkach NM,Gumeniuk MI,Tarnavskiy SS,Yarmoluk SM

    更新日期:2020-07-01 00:00:00

  • Dosing antibiotics in neonates: review of the pharmacokinetic data.

    abstract::Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

    更新日期:2017-09-01 00:00:00

  • Potential for adaptation overrides cost of resistance.

    abstract:AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Moura de Sousa J,Sousa A,Bourgard C,Gordo I

    更新日期:2015-01-01 00:00:00

  • Cryptococcus neoformans glucuronoxylomannan fractions of different molecular masses are functionally distinct.

    abstract:AIMS:Glucuronoxylomannan (GXM) is the major polysaccharide component of Cryptococcus neoformans. We evaluated in this study whether GXM fractions of different molecular masses were functionally distinct. MATERIALS & METHODS:GXM samples isolated from C. neoformans cultures were fractionated to generate polysaccharide p...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Albuquerque PC,Fonseca FL,Dutra FF,Bozza MT,Frases S,Casadevall A,Rodrigues ML

    更新日期:2014-01-01 00:00:00

  • Micafungin sodium, the second of the echinocandin class of antifungals: theory and practice.

    abstract::Micafungin is a new drug in the echinocandin class and is currently being investigated in Phase III clinical trials. Like other echinocandins, it inhibits 1,3-beta-D-glucan synthesis, thus achieving fungicidal activity against virtually all Candida spp., including those resistant to fluconazole, and fungistatic activi...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Vehreschild JJ,Cornely OA

    更新日期:2006-08-01 00:00:00

  • Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.

    abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Dunn JD,Valdivia RH

    更新日期:2010-08-01 00:00:00

  • Prevalence of carbapenemase-producing organisms at the Kidney Center of Rawalpindi (Pakistan) and evaluation of an advanced molecular microarray-based carbapenemase assay.

    abstract:AIM:A DNA microarray-based assay for the detection of antimicrobial resistance (AMR) genes was used to study carbapenemase-producing organisms at the Kidney Center of Rawalpindi, Pakistan. METHODS:The evaluation of this assay was performed using 97 reference strains with confirmed AMR genes. Testing of 7857 clinical s...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Braun SD,Jamil B,Syed MA,Abbasi SA,Weiß D,Slickers P,Monecke S,Engelmann I,Ehricht R

    更新日期:2018-09-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • The role of bacteriophages in periodontal health and disease.

    abstract::The human periodontium health is commonly compromised by chronic inflammatory conditions and has become a major public health concern. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pinto G,Silva MD,Peddey M,Sillankorva S,Azeredo J

    更新日期:2016-10-01 00:00:00

  • Treatment of hepatitis B virus: an update.

    abstract::Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Ward H,Tang L,Poonia B,Kottilil S

    更新日期:2016-12-01 00:00:00

  • TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.

    abstract:AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

    更新日期:2018-06-01 00:00:00

  • The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach.

    abstract::Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pich OQ,Merrell DS

    更新日期:2013-06-01 00:00:00

  • Promises and failures of gallium as an antibacterial agent.

    abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Minandri F,Bonchi C,Frangipani E,Imperi F,Visca P

    更新日期:2014-01-01 00:00:00

  • Controversies in the treatment of pneumococcal community-acquired pneumonia.

    abstract::Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Feldman C,Anderson R

    更新日期:2006-10-01 00:00:00

  • Variants of the bile: solubility test to differentiate Streptococcus pneumoniae from other viridans group streptococci.

    abstract::Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ercibengoa M,Morales M,Alonso M,Ardanuy C,Marimón JM

    更新日期:2019-07-01 00:00:00

  • Antimicrobial activity and resistance selection of different bioglass S53P4 formulations against multidrug resistant strains.

    abstract:AIMS:This study aimed to evaluate the antimicrobial activity of two different formulations of bioglass BAG-S53P4 against multiresistant microorganisms involved in bone infections, and the capability of bioglass to select for resistance. METHODS:Antibacterial activity was evaluated by means of killing curves. The abili...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Drago L,De Vecchi E,Bortolin M,Toscano M,Mattina R,Romanò CL

    更新日期:2015-01-01 00:00:00

  • Better than a pound of cure: preventing the development of multidrug-resistant tuberculosis.

    abstract::Diagnostic and treatment delays contribute to increased death and disability among the 490,000 adults and children who develop multidrug-resistant (MDR) tuberculosis every year. Since the treatment of MDR tuberculosis is complex, costly and often toxic, tuberculosis control programs should prioritize strategies to pre...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Byrne AL,Fox GJ,Marais BJ

    更新日期:2018-04-01 00:00:00

  • Hepatitis E in developed countries: current status and future perspectives.

    abstract::Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Dalton HR,Kamar N,Izopet J

    更新日期:2014-01-01 00:00:00