Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

abstract：AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...

journal_title：Future microbiology

authors： Chen ZF,Ai LY,Wang JL,Ren LL,Yu YN,Xu J,Chen HY,Yu J,Li M,Qin WX,Ma X,Shen N,Chen YX,Hong J,Fang JY

更新日期：2015-01-01 00:00:00

abstract：:The plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. Over time, the sensitivity and reproducibility of the technique has been improved. Usually, the number of...

journal_title：Future microbiology

authors： Edouard S,Raoult D

更新日期：2013-10-01 00:00:00

abstract：:The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and devel...

journal_title：Future microbiology

authors： Herrmann M,Abdullah S,Alabi A,Alonso P,Friedrich AW,Fuhr G,Germann A,Kern WV,Kremsner PG,Mandomando I,Mellmann AC,Pluschke G,Rieg S,Ruffing U,Schaumburg F,Tanner M,Peters G,von Briesen H,von Eiff C,von Müller L,Gr

更新日期：2013-01-01 00:00:00

abstract：:Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...

journal_title：Future microbiology

authors： Narra HP,Sahni A,Walker DH,Sahni SK

更新日期：2020-06-01 00:00:00

abstract：AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

journal_title：Future microbiology

authors： Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

更新日期：2018-06-01 00:00:00

abstract：:Resistance continues to emerge as a leading cause for antiretroviral treatment failure. Several mutations in HIV reverse transcriptase (RT) confer resistance to non-nucleoside inhibitors (NNRTIs), vital components of antiretroviral combination therapies. Since the majority of mutations are located in the NNRTI binding...

journal_title：Future microbiology

authors： Frey KM

更新日期：2015-01-01 00:00:00

abstract：:Recognition of bacterial infection is the first key step to the initiation of an inflammatory response and host defense. Transmembrane proteins of the Toll-like receptor family have long been recognized as key detectors of the extracellular presence of pathogens. Recently, much research has identified a variety of int...

journal_title：Future microbiology

authors： Evans TJ

更新日期：2009-02-01 00:00:00

abstract：AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...

journal_title：Future microbiology

authors： Xu S,Yang J,Yin C,Zhao X

更新日期：2018-02-01 00:00:00

abstract：:Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were signific...

journal_title：Future microbiology

authors： Guo M,Yao J,Yang F,Liu W,Bai H,Ma J,Ma X,Zhang J,Fang Y,Miao Y,Sun J,Zhang Y,Zhao H

更新日期：2020-02-01 00:00:00

abstract：AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

journal_title：Future microbiology

authors： Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

更新日期：2013-02-01 00:00:00

abstract：:The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A m...

journal_title：Future microbiology

authors： Cohen A,Bont L,Engelhard D,Moore E,Fernández D,Kreisberg-Greenblatt R,Oved K,Eden E,Hays JP

更新日期：2015-01-01 00:00:00

abstract：AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in...

journal_title：Future microbiology

authors： Huang X,Wang F,Chen Y,Liu T,Wang J,Hu J,Jie J,Chen F,Wang S,Shen Z,Yu L,Yu K,Liang Y

更新日期：2012-02-01 00:00:00

abstract：:The time is ripe to usher in a new paradigm in infection control and to move beyond our sole reliance on broad-spectrum antibiotics whose use results in extensive collateral damage to our microbiome and, in so doing, exerts significant selective pressures for resistance to emerge. We propose to supplement the existing...

journal_title：Future microbiology

authors： Qiu XQ,Roy SM,Riley MA

更新日期：2015-01-01 00:00:00

abstract：:The Enterococcus species is the third main cause of infective endocarditis (IE) worldwide, and it is gaining relevance, especially among healthcare-associated cases. Patients with enterococcal IE are older and have more comorbidities than other types of IE. Classical treatment options are limited due to the emergence ...

journal_title：Future microbiology

authors： Pericás JM,Zboromyrska Y,Cervera C,Castañeda X,Almela M,Garcia-de-la-Maria C,Mestres C,Falces C,Quintana E,Ninot S,Llopis J,Marco F,Moreno A,Miró JM

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

journal_title：Future microbiology

authors： Moura de Sousa J,Sousa A,Bourgard C,Gordo I

更新日期：2015-01-01 00:00:00

abstract：:Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinic...

journal_title：Future microbiology

authors： Koutsakos M,Nguyen TH,Barclay WS,Kedzierska K

更新日期：2016-01-01 00:00:00

abstract：AIM:To isolate and characterize the two phenotypically distinct subpopulations from Klebsiella pneumoniae clonal cultures grown in the simulate microgravity environment. MATERIALS & METHODS:Here clonal culture of K. pneumoniae strain ATCC BAA-1705 was grown within a vertically rotating wall vessel bioreactor. Microsco...

journal_title：Future microbiology

authors： Wang H,Li W,Gu L,Gao X,Ni B,Deng H,Yang R,Han Y

更新日期：2017-09-01 00:00:00

abstract：:European Respiratory Society Congress, Amsterdam, 26-30 September 2015, and CHEST 2015, Montréal, Canada, 24-28 October 2015 With approximately 50,000 deaths in the US and EU attributed to antibacterial resistance each year, together with several million days of hospital care [1], the need to address resistance mechan...

journal_title：Future microbiology

authors： Sethi S,Bryan J

更新日期：2016-01-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...

journal_title：Future microbiology

authors： Karampatakis T,Antachopoulos C,Tsakris A,Roilides E

更新日期：2017-07-01 00:00:00

abstract：:Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...

journal_title：Future microbiology

authors： Tupin A,Gualtieri M,Brodolin K,Leonetti JP

更新日期：2009-03-01 00:00:00

abstract：:Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTI...

journal_title：Future microbiology

authors： Sluis-Cremer N,Wainberg MA,Schinazi RF

更新日期：2015-01-01 00:00:00

abstract：:In the past few months, there has been public discussion relating to a new perspective on blood safety and specifically upon measures to prevent or discourage donation by individuals with a diagnosis of myalgic encephalopathy-chronic fatigue syndrome. This reflects an intriguing interplay between science, public healt...

journal_title：Future microbiology

authors： Dodd RY

更新日期：2011-04-01 00:00:00

abstract：:This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

journal_title：Future microbiology

authors： Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

更新日期：2015-01-01 00:00:00

abstract：:Traditionally, the patients believed to be at highest risk of invasive aspergillosis (IA) are those who are neutropenic due to chemotherapy for hematological malignancy or those undergoing allogeneic hematopoietic stem cell transplantation. However, emerging data show that other patients are vulnerable to IA, even tho...

journal_title：Future microbiology

authors： Sheppard D,Grist LM

更新日期：2010-07-01 00:00:00

abstract：:HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease caused by HCV infection is the most common indication for orthotopic liver transplantation. Unfortunately, reinfection of the new...

journal_title：Future microbiology

authors： Angus AG,Patel AH

更新日期：2011-03-01 00:00:00

abstract：:Using the murine CMV animal model and the well-established model of Cre-lox-P-mediated green-fluorescence tagging of endothelial cell (EC)-derived mouse CMV to quantify the role of infected ECs in transplantation-associated CMV dissemination (in mice expressing Cre recombinase under the control of either the Tie2 or t...

journal_title：Future microbiology

authors： Gerna G

更新日期：2012-04-01 00:00:00

abstract：:During its productive infection, HSV-1 dramatically remodels the architecture and physiology of the host cell nucleus. The immediate-early proteins, the first viral proteins to be expressed during infection, are key players in this process. Here, we review the known properties and functions of immediate-early protein ...

journal_title：Future microbiology

authors： Rice SA,Davido DJ

更新日期：2013-03-01 00:00:00

abstract：AIM:The purpose of current study is to find out relationship between cas9 gene and antimicrobial resistance in Campylobacter jejuni NCTC11168. MATERIALS & METHODS:The involvement of the cas9 gene in antimicrobial resistance of C. jejuni was determined by assessment of minimum inhibitory concentration, clustered regula...

journal_title：Future microbiology

authors： Shabbir MA,Wu Q,Shabbir MZ,Sajid A,Ahmed S,Sattar A,Tang Y,Li J,Maan MK,Hao H,Yuan Z

更新日期：2018-12-01 00:00:00

abstract：:While high-throughput protein-protein interaction screens were first published approximately 10 years ago, systematic attempts to map interactions among viruses and hosts started only a few years ago. HIV-human interactions dominate host-pathogen interaction databases (with approximately 2000 interactions) despite the...

journal_title：Future microbiology

authors： Mendez-Rios J,Uetz P

更新日期：2010-02-01 00:00:00

abstract：:Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies includin...

journal_title：Future microbiology

authors： Kato-Maeda M,Metcalfe JZ,Flores L

更新日期：2011-02-01 00:00:00