Abstract:
:Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective against resistant organisms. Structures of efflux pumps bound to substrates and inhibitors have aided the design of compounds with lower affinity for the pump or inhibitors that more effectively block the pump. Structures of β-lactamase enzymes have revealed the mechanisms of action toward key carbapenems and structures of gyrase have aided the design of compounds that are less susceptible to point mutations.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Reeve SM,Lombardo MN,Anderson ACdoi
10.2217/fmb.15.78subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1727-33issue
11eissn
1746-0913issn
1746-0921journal_volume
10pub_type
杂志文章,评审abstract::Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genet...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.09.96
更新日期:2009-12-01 00:00:00
abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0134
更新日期:2019-08-01 00:00:00
abstract::Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0266
更新日期:2020-06-01 00:00:00
abstract:: Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded comp...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.13.140
更新日期:2014-01-01 00:00:00
abstract::Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0157
更新日期:2019-11-01 00:00:00
abstract::Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0280
更新日期:2020-08-01 00:00:00
abstract::Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected a...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0079
更新日期:2020-10-01 00:00:00
abstract::Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.98
更新日期:2015-01-01 00:00:00
abstract::HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease caused by HCV infection is the most common indication for orthotopic liver transplantation. Unfortunately, reinfection of the new...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.9
更新日期:2011-03-01 00:00:00
abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...
journal_title:Future microbiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2217/fmb-2018-0067
更新日期:2018-08-01 00:00:00
abstract:AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.127
更新日期:2016-01-01 00:00:00
abstract:AIM:To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source. MATERIALS & METHODS:The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscop...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0245
更新日期:2018-12-01 00:00:00
abstract::A number of viruses in the family Arenaviridae cause severe illness in humans. Lassa virus in West Africa and a number of agents in South America produce hemorrhagic fever in persons exposed to aerosolized excretions of the pathogens' rodent hosts. Because arenaviruses are not transmitted by arthropods, and person-to-...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.132
更新日期:2011-12-01 00:00:00
abstract::European Respiratory Society Congress, Amsterdam, 26-30 September 2015, and CHEST 2015, Montréal, Canada, 24-28 October 2015 With approximately 50,000 deaths in the US and EU attributed to antibacterial resistance each year, together with several million days of hospital care [1], the need to address resistance mechan...
journal_title:Future microbiology
pub_type:
doi:10.2217/fmb-2016-0006
更新日期:2016-01-01 00:00:00
abstract::During its productive infection, HSV-1 dramatically remodels the architecture and physiology of the host cell nucleus. The immediate-early proteins, the first viral proteins to be expressed during infection, are key players in this process. Here, we review the known properties and functions of immediate-early protein ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.4
更新日期:2013-03-01 00:00:00
abstract:AIM:To evaluate if radiation used in radiotherapy can cause changes in the virulence potential of Candida tropicalis ATCC 750. MATERIALS & METHODS:C. tropicalis was exposed in vitro to identical dose and scheme of irradiation would be used in patients with head and neck cancer. Some virulence parameters were analyzed ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2017-0137
更新日期:2017-12-01 00:00:00
abstract:AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.66
更新日期:2015-01-01 00:00:00
abstract::Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2017-0170
更新日期:2018-03-01 00:00:00
abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.77
更新日期:2010-08-01 00:00:00
abstract::Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.83
更新日期:2015-01-01 00:00:00
abstract::Resistance continues to emerge as a leading cause for antiretroviral treatment failure. Several mutations in HIV reverse transcriptase (RT) confer resistance to non-nucleoside inhibitors (NNRTIs), vital components of antiretroviral combination therapies. Since the majority of mutations are located in the NNRTI binding...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.122
更新日期:2015-01-01 00:00:00
abstract::Aim: In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. Materials & methods: If subjects presented with febrile symptoms at the ED, 13 biomarkers' levels, including CD64 on neutrophils (n...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0256
更新日期:2020-02-01 00:00:00
abstract:AIM:A DNA microarray-based assay for the detection of antimicrobial resistance (AMR) genes was used to study carbapenemase-producing organisms at the Kidney Center of Rawalpindi, Pakistan. METHODS:The evaluation of this assay was performed using 97 reference strains with confirmed AMR genes. Testing of 7857 clinical s...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0082
更新日期:2018-09-01 00:00:00
abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.3
更新日期:2014-01-01 00:00:00
abstract::Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0200
更新日期:2017-07-01 00:00:00
abstract::Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.89
更新日期:2014-01-01 00:00:00
abstract:AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2017-0070
更新日期:2018-02-01 00:00:00
abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.34
更新日期:2010-05-01 00:00:00
abstract::Aim: Multidrug-resistant Staphylococcus aureus isolates have become a serious concern in clinical microbiology. Antisense strategy, which specifically targets essential genes, could be helpful. Materials & methods:S. aureus cultures were treated with peptide conjugate-peptide nucleic acid (PPNA) specific for the gyrA ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0103
更新日期:2019-09-01 00:00:00
abstract::Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-formi...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0299
更新日期:2019-07-01 00:00:00