Abstract:
AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. RESULTS:pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. CONCLUSION:pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BPdoi
10.2217/fmb.12.134subject
Has Abstractpub_date
2013-02-01 00:00:00pages
257-69issue
2eissn
1746-0913issn
1746-0921journal_volume
8pub_type
杂志文章abstract::Aim:Cryptococcus neoformans is the major agent of cryptococcosis. The main virulence factor is the polysaccharide (PS) capsule. Changes in cryptococcal PS properties have been poorly elucidated. Materials & methods: We analyzed the mechanical properties of secreted PS and intact capsules, using dynamic light scatterin...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0320
更新日期:2019-07-01 00:00:00
abstract::The aggregate of microorganisms residing on the surface of the skin, in the oropharynx and in the GI tract, known as the human microbiota, play a major role as natural reservoirs for bacterial resistance to antibiotics. Fluoroquinolones (FQ) are among the most prescribed antibiotics and a major increase in FQ resistan...
journal_title:Future microbiology
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0234
更新日期:2018-12-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Future microbiology
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.12.81
更新日期:2012-09-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0253
更新日期:2019-03-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.1.1.113
更新日期:2006-06-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 评论,杂志文章
doi:10.2217/fmb.12.12
更新日期:2012-04-01 00:00:00
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journal_title:Future microbiology
pub_type:
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更新日期:2018-10-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.66
更新日期:2015-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.62
更新日期:2011-07-01 00:00:00
abstract::Cytomegalovirus (CMV) manifestations remain important complications after allogeneic hematopoietic stem cell transplantation (HSCT), even in the current era. Unfortunately, available anti-CMV agents, mainly viral polymerase inhibitors, have a substantial risk of myelosuppression and nephrotoxicity. Letermovir, a novel...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0250
更新日期:2019-02-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
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更新日期:2011-02-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
abstract::Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of th...
journal_title:Future microbiology
pub_type: 面试
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更新日期:2016-08-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.81
更新日期:2015-01-01 00:00:00