Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.


AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. RESULTS:pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. CONCLUSION:pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue.


Future Microbiol


Future microbiology


Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP




Has Abstract


2013-02-01 00:00:00












  • Controversies in the treatment of pneumococcal community-acquired pneumonia.

    abstract::Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Feldman C,Anderson R

    更新日期:2006-10-01 00:00:00

  • Epigenetics in the unicellular parasite Entamoeba histolytica.

    abstract::Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Tovy A,Ankri S

    更新日期:2010-12-01 00:00:00

  • Novel isoniazid derivative as promising antituberculosis agent.

    abstract::Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Volynets GP,Tukalo MA,Bdzhola VG,Derkach NM,Gumeniuk MI,Tarnavskiy SS,Yarmoluk SM

    更新日期:2020-07-01 00:00:00

  • MAPK cell-cycle regulation in Saccharomyces cerevisiae and Candida albicans.

    abstract::The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Correia I,Alonso-Monge R,Pla J

    更新日期:2010-07-01 00:00:00

  • Immunotherapeutic potential of neutralizing antibodies targeting conserved regions of the HCV envelope glycoprotein E2.

    abstract::HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease caused by HCV infection is the most common indication for orthotopic liver transplantation. Unfortunately, reinfection of the new...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Angus AG,Patel AH

    更新日期:2011-03-01 00:00:00

  • Septic patients in the intensive care unit present different nasal microbiotas.

    abstract:AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dom...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H

    更新日期:2019-03-01 00:00:00

  • A novel triterpene from Astraeus hygrometricus induces reactive oxygen species leading to death in Leishmania donovani.

    abstract:AIM:The effect of astrakurkurone, a novel triterpene, isolated from Indian mushroom Astraeus hygrometricus has been investigated to elucidate the mechanisms involved in selective cell death of Leishmania donovani. MATERIALS & METHODS:The hypotheses were investigated using flow-cytometry, scanning electron microscopy a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Mallick S,Dey S,Mandal S,Dutta A,Mukherjee D,Biswas G,Chatterjee S,Mallick S,Lai TK,Acharya K,Pal C

    更新日期:2015-01-01 00:00:00

  • Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates.

    abstract:AIM:To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. MATERIAL & METHODS:Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spati...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Freitas AI,Lopes N,Oliveira F,Brás S,França Â,Vasconcelos C,Vilanova M,Cerca N

    更新日期:2018-03-01 00:00:00

  • Variants of the bile: solubility test to differentiate Streptococcus pneumoniae from other viridans group streptococci.

    abstract::Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ercibengoa M,Morales M,Alonso M,Ardanuy C,Marimón JM

    更新日期:2019-07-01 00:00:00

  • The contribution of genomics to the study of Q fever.

    abstract::Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: D'Amato F,Eldin C,Raoult D

    更新日期:2016-01-01 00:00:00

  • Combination antifungal therapy: the new frontier.

    abstract::The past decade has seen a significant increase in the incidence of invasive fungal infections. The antifungal armamentarium for the treatment of serious fungal infections remains limited. A possible approach to overcoming antifungal drug resistance and high mortality rates seen in severe fungal infections is to combi...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Vazquez JA

    更新日期:2007-04-01 00:00:00

  • Genetics of Coxiella burnetii: on the path of specialization.

    abstract::Coxiella burnetii is an extremely infectious, zoonotic agent that causes Q fever in humans. With the exception of New Zealand, the bacterium is distributed worldwide. Coxiella is classified as a select agent based on its past and potential use as a bioweapon and its threat to public health. Despite decades of research...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Minnick MF,Raghavan R

    更新日期:2011-11-01 00:00:00

  • Preclinical efficacy of a virus-like particle-based vaccine against avian influenza H5N1.

    abstract::Evaluation of: Kang S-M, Yoo D-G, Lipatov AS et al.: Induction of long-term protective immune responses by influenza H5N1 virus-like particles. PLoS ONE 4, e4667 (2009). This article describes a long-term protective effect of a vaccine candidate against avian influenza H5N1 that is based on A/Viet Nam1203/04 proteins ...

    journal_title:Future microbiology

    pub_type: 评论,杂志文章


    authors: Arnon R,Ben-Yedidia T

    更新日期:2009-06-01 00:00:00

  • Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.

    abstract::Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTI...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Sluis-Cremer N,Wainberg MA,Schinazi RF

    更新日期:2015-01-01 00:00:00

  • Bacterial triggering of inflammation by intracellular sensors.

    abstract::Recognition of bacterial infection is the first key step to the initiation of an inflammatory response and host defense. Transmembrane proteins of the Toll-like receptor family have long been recognized as key detectors of the extracellular presence of pathogens. Recently, much research has identified a variety of int...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Evans TJ

    更新日期:2009-02-01 00:00:00

  • Managing invasive fungal disease in immunocompromised patients.

    abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...

    journal_title:Future microbiology



    authors: Maertens J,Bryan J

    更新日期:2010-12-01 00:00:00

  • Proteomic studies of Bacillus anthracis.

    abstract::Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological cause of anthrax, a rare lethal disease of animals and humans. Development of anthrax countermeasures has gained increasing attention owing to the potential use of B. anthracis spores as a bioterror weapon. The various forms of...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Chitlaru T,Shafferman A

    更新日期:2009-10-01 00:00:00

  • Salmonella enterica as a vaccine carrier.

    abstract::Salmonella enterica is an invasive, facultative intracellular gastrointestinal pathogen causing human diseases such as gastroenteritis and typhoid fever. Virulence-attenuated strains of this pathogen have interesting capacities for the generation of live vaccines. Attenuated live typhoidal and nontyphoidal Salmonella ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Hegazy WA,Hensel M

    更新日期:2012-01-01 00:00:00

  • Pre-implementation guidelines for infectious disease point-of-care testing in medical institutions.

    abstract::Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-imp...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: van der Eijk AA,Tintu AN,Hays JP

    更新日期:2017-01-01 00:00:00

  • Endothelial cells and CMV dissemination.

    abstract::Using the murine CMV animal model and the well-established model of Cre-lox-P-mediated green-fluorescence tagging of endothelial cell (EC)-derived mouse CMV to quantify the role of infected ECs in transplantation-associated CMV dissemination (in mice expressing Cre recombinase under the control of either the Tie2 or t...

    journal_title:Future microbiology

    pub_type: 评论,杂志文章


    authors: Gerna G

    更新日期:2012-04-01 00:00:00

  • Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?

    abstract::Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Al-Dujaili LJ,Clerkin PP,Clement C,McFerrin HE,Bhattacharjee PS,Varnell ED,Kaufman HE,Hill JM

    更新日期:2011-08-01 00:00:00

  • A multicenter, open-label study of posaconazole oral suspension in the treatment of invasive fungal infections in patients refractory to or intolerant of first-line therapy.

    abstract:AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in...

    journal_title:Future microbiology

    pub_type: 杂志文章,多中心研究


    authors: Huang X,Wang F,Chen Y,Liu T,Wang J,Hu J,Jie J,Chen F,Wang S,Shen Z,Yu L,Yu K,Liang Y

    更新日期:2012-02-01 00:00:00

  • Raman spectroscopy: lighting up the future of microbial identification.

    abstract::Over the last decade Raman spectroscopy has become established as a physicochemical technique for the rapid identification of microbes. This powerful analytical method generates a spectroscopic fingerprint from the microbial sample, which provides quantitative and qualitative information that can be used to characteri...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ashton L,Lau K,Winder CL,Goodacre R

    更新日期:2011-09-01 00:00:00

  • The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach.

    abstract::Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pich OQ,Merrell DS

    更新日期:2013-06-01 00:00:00

  • Helicobacter pylori virulence factors in development of gastric carcinoma.

    abstract::Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Wang MY,Liu XF,Gao XZ

    更新日期:2015-01-01 00:00:00

  • Origin of hepatitis delta virus.

    abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Taylor J,Pelchat M

    更新日期:2010-03-01 00:00:00

  • Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence.

    abstract::Living organisms adapt to the dynamic external environment for their survival. Environmental adaptation in prokaryotes is thought to be primarily accomplished by signaling events mediated by two-component systems, consisting of histidine kinases and response regulators. However, eukaryotic-like serine/threonine kinase...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Burnside K,Rajagopal L

    更新日期:2011-07-01 00:00:00

  • Prospects for defined epitope vaccines for respiratory syncytial virus.

    abstract::The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine c...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Anderson R,Huang Y,Langley JM

    更新日期:2010-04-01 00:00:00

  • TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.

    abstract:AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

    更新日期:2018-06-01 00:00:00

  • The CRISPR-cas system promotes antimicrobial resistance in Campylobacter jejuni.

    abstract:AIM:The purpose of current study is to find out relationship between cas9 gene and antimicrobial resistance in Campylobacter jejuni NCTC11168. MATERIALS & METHODS:The involvement of the cas9 gene in antimicrobial resistance of C. jejuni was determined by assessment of minimum inhibitory concentration, clustered regula...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Shabbir MA,Wu Q,Shabbir MZ,Sajid A,Ahmed S,Sattar A,Tang Y,Li J,Maan MK,Hao H,Yuan Z

    更新日期:2018-12-01 00:00:00