Abstract:
AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. RESULTS:pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. CONCLUSION:pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BPdoi
10.2217/fmb.12.134subject
Has Abstractpub_date
2013-02-01 00:00:00pages
257-69issue
2eissn
1746-0913issn
1746-0921journal_volume
8pub_type
杂志文章abstract::Breastfeeding is a major determinant of human health. Breast milk is not sterile and ecological large-scale sequencing methods have revealed an unsuspected microbial diversity that plays an important role. However, microbiological analysis at the species level has been neglected while it is a prerequisite before under...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.11.38
更新日期:2011-05-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0012
更新日期:2018-06-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.165
更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0085
更新日期:2020-07-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0080
更新日期:2021-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.77
更新日期:2010-08-01 00:00:00
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journal_title:Future microbiology
pub_type:
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更新日期:2016-01-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0224
更新日期:2017-08-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.18
更新日期:2013-04-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.73
更新日期:2011-08-01 00:00:00