Abstract:
:Malaria remains a major international health challenge. Resistance to a number of existing drugs and evidence of the emergence of artemisinin resistance has emphasized the need for new antimalarials. A new approach has been the preparation of dual-function compounds that include a chloroquine-like antimalarial group and a group that resembles a chloroquine chemosensitizer. This article reviews the recent discovery of such dual-function antimalarials that are proposed to target both hemozoin formation and the chloroquine resistance transporter, PfCRT. These are discussed in relation to the mechanism of action of 4-aminoquinolines, chloroquine resistance and resistance reversal.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Egan TJ,Kuter Ddoi
10.2217/fmb.13.18subject
Has Abstractpub_date
2013-04-01 00:00:00pages
475-89issue
4eissn
1746-0913issn
1746-0921journal_volume
8pub_type
杂志文章,评审abstract:AIMS:We explored changes in antibiotic susceptibility of Serratia marcescens in the last 50 years by comparing isolates collected between 1945 and 1950, and current isolates. MATERIALS & METHODS:Isolates were divided into three groups: environmental, clinical and 'old'. Susceptibility was determined by microdilution. ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.12.40
更新日期:2012-06-01 00:00:00
abstract::West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.67
更新日期:2014-01-01 00:00:00
abstract::The Enterococcus species is the third main cause of infective endocarditis (IE) worldwide, and it is gaining relevance, especially among healthcare-associated cases. Patients with enterococcal IE are older and have more comorbidities than other types of IE. Classical treatment options are limited due to the emergence ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.46
更新日期:2015-01-01 00:00:00
abstract::Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genet...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.09.96
更新日期:2009-12-01 00:00:00
abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.12.134
更新日期:2013-02-01 00:00:00
abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...
journal_title:Future microbiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2217/fmb-2018-0067
更新日期:2018-08-01 00:00:00
abstract::Diagnostic and treatment delays contribute to increased death and disability among the 490,000 adults and children who develop multidrug-resistant (MDR) tuberculosis every year. Since the treatment of MDR tuberculosis is complex, costly and often toxic, tuberculosis control programs should prioritize strategies to pre...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2017-0236
更新日期:2018-04-01 00:00:00
abstract::Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2017-0058
更新日期:2017-09-01 00:00:00
abstract::Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-re...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.131
更新日期:2016-01-01 00:00:00
abstract::Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.89
更新日期:2014-01-01 00:00:00
abstract:AIM:We evaluated a Staphylococcus argenteus-specific diagnostic profile of matrix-assisted laser desorption/ionization time-of-flight mass spectrometer for accurate identification of this novel bacterium. MATERIALS & METHODS:Staphylococcus argenteus was identified based on negative crtM gene and presence of specific s...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0015
更新日期:2018-07-01 00:00:00
abstract::Oritavancin is a lipoglycopeptide antibiotic with activity against aerobic and anaerobic Gram-positive bacteria. Oritavancin separates itself from other glycopeptides through its potent in vitro activity against resistant isolates of Staphylococcus aureus, Enterococcus spp. and Streptococcus spp. Oritavancin possesses...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.3.3.251
更新日期:2008-06-01 00:00:00
abstract:AIM:The aim was to evaluate the in vitro activity of fosfomycin against common uropathogens in a fosfomycin-naive population in India. METHODS:The authors prospectively collected and tested all consecutive isolates of Escherichia coli and Enterococcus spp. from urine samples between December 2009 and April 2010. RESU...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.13.31
更新日期:2013-05-01 00:00:00
abstract::Surgical procedures for the symptomatic removal of the gallbladder and the vermiform appendix have been posited to adversely shift the assemblage of the intestinal microbiome increasing the risk of disease. The associated mechanisms have been linked with dysbiosis of the gut microbiota. Cholecystectomy causes changes ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0325
更新日期:2020-05-01 00:00:00
abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.3
更新日期:2014-01-01 00:00:00
abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...
journal_title:Future microbiology
pub_type:
doi:10.2217/fmb.10.142
更新日期:2010-12-01 00:00:00
abstract::Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0073
更新日期:2019-07-01 00:00:00
abstract::Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0266
更新日期:2020-06-01 00:00:00
abstract::Traditionally, glycoproteins have been considered the exclusive property of eukaryotes and archaea, but it is now evident that glycoproteins are found in all domains of life. In recent years N-linked glycosylation among some epsilon-proteobacteria has emerged as a new and exciting research area and represents a useful...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.09.10
更新日期:2009-05-01 00:00:00
abstract::Chlamydial infections cause a wide range of acute and chronic diseases. Chlamydia trachomatis is the most common sexually transmitted bacterium while Chlamydia pneumoniae causes infections of the upper and lower respiratory tract. Chlamydia are obligate, intracellular bacteria with a biphasic developmental cycle that ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.13
更新日期:2014-01-01 00:00:00
abstract::This paper analyzes the most recent reports regarding the direct and indirect effects of the 13-valent pneumococcal conjugate vaccine (PCV13) when administered to infants and young children. PCV13 extends the protective effects reported for the 7-valent pneumococcal conjugate vaccine (PCV7). A further reduction in the...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.81
更新日期:2015-01-01 00:00:00
abstract::Living organisms adapt to the dynamic external environment for their survival. Environmental adaptation in prokaryotes is thought to be primarily accomplished by signaling events mediated by two-component systems, consisting of histidine kinases and response regulators. However, eukaryotic-like serine/threonine kinase...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.62
更新日期:2011-07-01 00:00:00
abstract::The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.72
更新日期:2010-07-01 00:00:00
abstract::Aim: Face masks are an important addition to our arsenal in the fight against COVID-19. The aim of this study is to present a novel method of measuring mask performance which can simultaneously assess both fabric penetration and leakage due to poor fit. Materials & methods: A synthetic aerosol is introduced into the l...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0292
更新日期:2021-01-01 00:00:00
abstract::Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of th...
journal_title:Future microbiology
pub_type: 面试
doi:10.2217/fmb-2016-0123
更新日期:2016-08-01 00:00:00
abstract::The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and devel...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.12.126
更新日期:2013-01-01 00:00:00
abstract::Organism-wide approaches examining the genetic mechanisms controlling growth and proliferation have proven to be a powerful tool in the study of pathogenic fungi. For many fungal pathogens techniques to study transcription and protein expression are particularly useful, and offer insights into infection processes by t...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.16.9
更新日期:2016-01-01 00:00:00
abstract::The time is ripe to usher in a new paradigm in infection control and to move beyond our sole reliance on broad-spectrum antibiotics whose use results in extensive collateral damage to our microbiome and, in so doing, exerts significant selective pressures for resistance to emerge. We propose to supplement the existing...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.104
更新日期:2015-01-01 00:00:00
abstract::Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires pro...
journal_title:Future microbiology
pub_type: 评论,杂志文章
doi:10.2217/fmb.11.103
更新日期:2011-10-01 00:00:00
abstract::Infections with Pseudomonas aeruginosa are a major health problem, especially for immune-compromised and cystic fibrosis patients, owing to the particular drug resistance of the microorganism. The aim of this review is to provide recent insights into strategies under investigation for prevention and therapy of these i...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.42
更新日期:2014-01-01 00:00:00